Abstract: The present invention relates to a method for the diagnosis of a disease or a risk for the development of a disease, in particular a disease which is mediated via the alternative pathway of the complement system. It further relates to a novel diagnostic marker and methods for identifying active agents.

Abstract: The present invention relates to an immortalized cell, an immortalized cell line comprising said immortalized cell, a cell culture comprising the immortalized cell or cell line, and a method for the production of an immortalized cell.

Abstract: A system for asservation of at least one hair comprising a hair root and a hair shaft. The system has a hair receiving device comprising a carrier plate element for receiving/accommodating the hair, and a cover plate element to be placed onto the carrier plate element for partially covering the hair. The cover plate element is adapted to be placed on the carrier plate element, and the carrier plate element has a first end, a second end, an outer surface and a hair-receiving surface. The hair-receiving surface has a first portion extending from the first end to a central portion of the hair-receiving surface, and a second portion extending from the central region to the second end, and the first portion has a structure having recesses and/or depressions for receiving the hair root, and a second portion for receiving the hair shaft.

Abstract: The invention relates to compositions and methods that utilize polymeric nanoparticles to deliver a therapeutic compound to ocular cells or ocular tissue. Provided is a drug-loaded micelle comprising self-assembled amphiphilic biopolymers, such as hydrophobically modified nucleic acids or polypeptides, for use as ophthalmic drug delivery system. Also provided are ophthalmic compositions and methods for preventing or treating an ophthalmic disease.

Abstract: The present invention relates to a method for the production of a pyrrolidine derivative.

Abstract: The present invention relates to a composition for the modulation of the activity of non-structure proteins and a compound contained therein.

Abstract: The present invention relates to a cytotoxic agent for the prophylaxis and/or treatment of a viral infection which is configured for the selective binding to a membrane receptor of virus-infected T lymphocytes, a pharmaceutical composition containing said cytotoxic agent, the use of the cytotoxic agent for the prophylaxis and/or treatment of viral infections, a method of finding cytotoxic agents, the use of a membrane receptor of virus-infected T lymphocytes which is overexpressed in comparison to non-infected T lymphocytes for the diagnosis of a viral infection.

Abstract: The present disclosure relates to the field of medical technology and in particular to the field of transcranial magnetic stimulation. A coil assembly is presented comprising a housing; a magnetic coil, and an electrode arrangement; wherein the magnetic coil is arranged in the housing and is adapted for generating a magnetic field for transcranial magnetic stimulation, wherein the electrode arrangement is arranged on the housing and adapted for deriving an EEG signal, and wherein the magnetic coil and the electrode arrangement are arranged on top of each other. Further, an electrode arrangement and a system for transcranial magnetic stimulation are provided.

Abstract: The instant invention relates to novel compounds useful for visualizing cell senescence, their preparation and use. In particular, this invention relates to novel fucose and amino-quinoline derivatives useful as senescence traces and their preparation.

Abstract: The present invention relates to a genetically modified Paramyxovirus, a pharmaceutical composition comprising this paramyxovirus, the use of a genetically modified Paramyxovirus for the therapeutic and/or prophylactic treatment of a tumor disease, and a method for the production of a pharmaceutical composition for the therapeutic or prophylactic treatment of a tumor disease.

Abstract: A system or method for motor rehabilitation of a paretic limb including: a first plurality of sensors for registering brain neurosignals; a body-actuator; a hybrid brain machine interface for decoding brain neurosignals into movements of the body-actuator; a second plurality of EMG sensors couplable to the paretic limb for registering its EMG activity; a device for providing the patient with instructions relative to a series of exercises and/or tasks to be carried out with the paretic limb; wherein upon carrying out a series of training sessions, each session comprising at least a set of such instructions, the hybrid brain machine interface is configured to switch between controlling the movements of the body-actuator based on the decoded brain neurosignals and a hybrid control of the movements of the body-actuator, when a significant level of decodable EMG activity has been registered, the hybrid control being an EMG-gated brain control.

Abstract: The invention relates to plants with increased resistance to plant pathogens, wherein the intracellular concentration of inositol pyrophosphate InsP7 and/or InsP8 in said plants is increased in comparison to the wild-type plant. In particular, the invention involves plants with increased expression of at least one protein involved in the synthesis of inositol pyrophosphates InsP7 and/or InsP8, such as, for example, proteins VIH2 and VIH1. The plants according to the invention are particularly resistant to the following plant pathogens: herbivore insects, for example larvae of agriculturally relevant pests, pathogenic fungi, such as necrotrophic fungi, or other plant pests, such as biotrophic pathogens. The invention further relates to the method for increasing plant resistance to plant pathogens, wherein the intracellular concentration of inositol pyrophosphates InsP7 and/or InsP8 is increased in comparison to the wild-type plant.

Abstract: The present invention relates to novel halogenated benzoxazines, methods for their production, their use for the diagnosis of diseases and their use for the production of medicaments for the diagnosis of diseases, preferably dementia diseases and in particular the Alzheimer's disease, in humans and/or animals.

Abstract: The present invention relates to a method for the production of recombinant expression vectors, a kit adapted to carrying out the method, a vector used in the context of the method, a cell containing such vector and the use of the vector.

Abstract: An arrangement for decoding a data word using a Reed-Muller code, has: (1) N input terminals, (2) a first level of E>>D summing modules, each summing module being linked with F different input terminals and each input terminal being linked with E summing modules, (3) a first level of E decision modules, each of the D inputs of each decision module being linked respectively with an output from D different summing modules, (4) a second level of H summing modules, (5) a second level of G decision modules, (6) a third level of G summing modules, and (7) G output terminals. N signifies the code length and D signifies the minimum spacing of the code, E is equal to D-2, F is equal to N/D, G is the number of symbols of the data word that need to be corrected and is a natural number between 1 and E<<D.

Abstract: The present invention relates to a method for the in vitro selection of at least one therapeutic cell subpopulation from an original cell population of eukaryotic cells, as well as to the therapeutic cell subpopulation selected by the method, which can be used for the treatment of diseases of tissues or organs. The selected cells are highly migrative and the method according to the invention provides for the selection of these highly migrative subpopulations from a sample comprising a mixture of cells.

Abstract: The present invention relates to a method for the in vitro selection of at least one therapeutic cell subpopulation from an original cell population of eukaryotic cells, as well as to the therapeutic cell subpopulation selected by the method, which can be used for the treatment of diseases of tissues or organs. The selected cells are highly migrative and the method according to the invention provides for the selection of these highly migrative subpopulations from a sample comprising a mixture of cells.

Abstract: The present invention relates to the finding that an until now orphan protein named receptor-like protein 1 (RLP1) in plants mediates an immune response to bacterial infections. Specifically, the invention relates to RLP1, now named receptor of enigmatic microbe-associated molecular pattern (MAMP) of Xanthomonas (REMAX), in Arabidopsis thaliana REMAX was found to recognise the presence of Xanthomonas and to initiate an immune signalling that eventually yields into a typical plant immune responses to bacterial infections. Furthermore, the invention relates to chimeric pattern recognition receptors (PRRs) composed of the extracellular domain of REMAX, which is the recognition site for sensing infection, and c-terminal portions of PRRs of other plant species. Also provided is a method to modulate the immune response of a plant to a bacterial infection by either increasing or decreasing the expression of REMAX or REMAX-like proteins, or the inventive chimeric PRRs in plants.

Abstract: The present invention relates to the use of at least one antibody which binds to the SUSD2 antigen, or to functional fragments of the antibody, in combination with at least one of the following: an antibody which binds to CD140b, an antibody which binds to CD56, and/or an antibody which binds to TNAP, or functional fragments thereof, for isolation of mesenchymal stem cells, especially those having particularly chondrocytic and osteogenic differentiation potential. The invention further relates to processes for isolating such stem cells using these antibodies.