Patents Assigned to Eberhard-Karls-Universitat
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Publication number: 20230406961Abstract: The present invention provides a novel bispecific anti-CD28 antibody format which is bivalent and comprises two CD28 binding sites, and at least one target binding site. The bispecific anti CD28 antibody of the invention is surprisingly advantageous due to its costimulatory activity which is strictly target cell restricted. The bispecific CD28 antibody of the invention is provided for use in the treatment of diseases either alone or in combination with a further bispecific antibody inducing a CD3/T cell receptor signal.Type: ApplicationFiled: November 3, 2021Publication date: December 21, 2023Applicants: Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts, Eberhard Karls Universität TübingenInventors: Helmut SALIH, Gundram JUNG, Martin PFLÜGLER, Latifa ZEKRI, Timo MANZ
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Publication number: 20230348462Abstract: The present invention relates to imidazo[4,5-c]quinoline compounds and to their use in the inhibition, regulation and/or modulation of signal transduction by ATM kinase and, in particular, for the treatment of ATM mediated diseases, especially cancer.Type: ApplicationFiled: May 1, 2023Publication date: November 2, 2023Applicants: Deutsches Krebsforschungszentrum, Eberhard Karls Universitat, Universitatsklinikum TubingenInventors: Stefan Laufer, Michael Forster, Teodor Dimitrov, Lars Zender, Athina Moschopoulou
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Publication number: 20230227520Abstract: The present invention relates to a protein having G-CSF-like activity comprising a) one or two polypeptide chains; b) a bundle of four ?-helices; and c) two or three amino acid linkers that connect contiguous bundle-forming ?-helices that are located on the same polypeptide chain, wherein each amino acid linker has a length between 2 and 20 amino acids. The invention also provides for a polynucleotide and a vector encoding the protein of the invention, host cells comprising said polynucleotide, a method for producing the protein of the invention and a pharmaceutical composition comprising the protein of the invention. The invention further relates to uses of the proteins of the invention as a research reagent and the use of the protein and/or pharmaceutical composition comprising the same as a medicament, e.g., for use in increasing stem cell production, for use in inducing hematopoiesis and/or for use in mobilizing hematopoietic stem cells.Type: ApplicationFiled: December 17, 2020Publication date: July 20, 2023Applicants: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Eberhard Karls Universität TübingenInventors: Mohammad ELGAMACY, Birte HERNANDEZ ALVAREZ, Yulia SKOKOWA
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Patent number: 11612646Abstract: The present invention provides a novel PSMA binding antibody termed 10B3 and pharmaceutical and diagnostic uses of the antibody 10B3. The PSMA antibody 10B3 does not cross-compete with the state of the art PMSA binding antibody J591 and has a reduced induction of antigen shift compared to J591 and a unique reactivity with squamous cell carcinoma (SCC) cells of different origin.Type: GrantFiled: January 16, 2017Date of Patent: March 28, 2023Assignees: Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts, Eberhard Karls Universität TübingenInventors: Helmut Salih, Fabian Vogt, Gundram Jung, Latifa Zekri-Metref
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Patent number: 11518777Abstract: The present invention relates to novel inhibitors of the shikimate pathway (shikimic acid pathway), pharmaceutical compositions comprising these novel inhibitors, methods for the production of the inhibitors and their use as antibiotics and herbicides.Type: GrantFiled: November 23, 2018Date of Patent: December 6, 2022Assignee: Eberhard Karls Universität TübingenInventors: Stephanie Grond, Karl Forchhammer, Klaus Brilisauer
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Patent number: 11459542Abstract: The present invention is in the field of the cultivation of biological cells and tissues with organ-like function on a microphysiological scale and provides a method for the microphysiological co-cultivation of 3D organoid tissue and at least one 2D cell layer.Type: GrantFiled: October 1, 2018Date of Patent: October 4, 2022Assignee: EBERHARD KARLS UNIVERSITÄT TÜBINGENInventors: Peter Loskill, Christopher Probst, Stefan Liebau, Kevin Achberger, Jasmin Haderspeck
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Patent number: 11332726Abstract: The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.Type: GrantFiled: April 30, 2019Date of Patent: May 17, 2022Assignees: EBERHARD KARLS UNIVERSITÄT TÜBINGEN MEDIZINISCHE FAKULTÄT, HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH FÜR DAS HELMHOLTZ-INSTITUT FÜR PHARMAZEUTISCHE FORSCHUNG SAARLAND (HIPS)Inventors: Michael Kormann, Lauren Mays Weddle, Claus-Michael Lehr, Brigitta Loretz, Emad Malaeksefat
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Patent number: 11307113Abstract: A method is used for determining a status of an encapsulation and/or a passivation layer of the encapsulation. The encapsulation forms a multi-layer system from multiple passivation layers arranged on top of one another and electrically contacted intermediate layers arranged between the passivation layers. The multi-layer system protects an implant surrounded by the encapsulation. In the method, an electrical measurement is carried out between a reference potential and at least one electrically contacted intermediate layer, and at least one current flowing between the reference potential and the at least one electrically contacted intermediate layer is detected. The at least one detected current is compared with at least one pre-determined threshold value. If the detected current falls below or exceeds the at least one threshold value, this indicates a functional state of a passivation layer adjacent to the at least one electrically contacted intermediate layer.Type: GrantFiled: August 16, 2018Date of Patent: April 19, 2022Assignees: AESCULAP AG, EBERHARD KARLS UNIVERSITÄT TÜBINGENInventors: Boris Hofmann, Markus Westerhausen
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Publication number: 20220098677Abstract: The present invention relates to a method for determining in a subject's biological sample the relative proportions of papillary renal cell carcinoma (pRCC), clear cell renal cell carcinoma (ccRCC), and chromophobe renal cell carcinoma (chRCC), an array comprising capture molecules capable of specifically binding to RCC signature genes or coding sequences thereof or products encoded thereby, and the use of RCC signature genes for classifying a subject into a renal cell carcinoma (RCC) risk group and/or for determining in a subject's biological sample the relative proportions of pRCC, ccRCC, and chRCC.Type: ApplicationFiled: October 7, 2021Publication date: March 31, 2022Applicants: Robert Bosch Gesellschaft für medizinische Forschung mbH, Eberhard Karls Universität Tuebingen Medizinische Fakultaet, Friedrich-Alexander-Universitaet Erlangen-NuernbergInventors: Florian Buettner, Elke Schaeffeler, Matthias Schwab, Stefan Winter, Jens Bedke, Arnulf Stenzl, Arndt Hartmann
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Patent number: 11286500Abstract: A nucleic acid molecule can code for an Orf virus vector promoter. A recombinant Orf virus vector can be included in a cell. The nucleic acid molecule, the vector and/or the cell can be included in a composition. The recombinant Orf virus vector can be used for the production of a foreign gene.Type: GrantFiled: January 19, 2018Date of Patent: March 29, 2022Assignee: EBERHARD KARLS UNIVERSITÄT TÜBINGEN MEDIZINISCHE FAKULTÄTInventors: Hanns-Joachim Rziha, Ralf Amann
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Patent number: 11142575Abstract: The present disclosure is related to improved methods for use of a humanized binding polypeptide specific for the alpha beta T cell receptor (??-TCR). In particular, this disclosure relates to improved methods of use of a humanized anti-??-TCR antibody, which is derived from the murine monoclonal antibody BMA031, in immunosuppressive therapy. Novel methods using humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-??TCR antibodies and/or fragments thereof) are also provided. Novel methods using repetitive administration of humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-??TCR antibodies and/or fragments thereof) to reduce ?? T cells in the subject relative to ?? cells in the subject are provided.Type: GrantFiled: October 30, 2014Date of Patent: October 12, 2021Assignees: GENZYME CORPORATION, EBERHARD KARLS UNIVERSITÄT TÜBINGENInventors: Gregor Blank, Rupert Handgretinger, Karin Schilbach, Gina Lacorcia, Daniel Snell, Andreas Menrad
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Patent number: 11058777Abstract: The present invention relates to a nucleic acid molecule which encodes a splice variant of the human P2RX7 receptor, and nucleic acid molecules derived therefrom, a recombinant vector containing said nucleic acid molecules, a host containing said recombinant vector, a polypeptide encoded by said nucleic acid molecules, a host cell expressing said polypeptide, a binding molecule binding to said polypeptide, a pharmaceutical composition comprising said binding molecule, a method for the production of the isolated polypeptide, and other methods and uses in connection therewith.Type: GrantFiled: May 17, 2018Date of Patent: July 13, 2021Assignees: EBERHARD KARLS UNIVERSITÄT TUEBINGEN MEDIZINISCHE FAKULTAET, DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OEFFENTLICHEN RECHTSInventors: Jens Gesche, Sorin Armeanu-Ebinger, Guido Seitz, Harald Surowy
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Patent number: 11024421Abstract: The automated determination of an individual function of a DPOAE level map with pdp,I=f(L1, L2) of human or animal hearing. The method may include reading into a main memory a model function with model parameters of a DPOAE level map, based upon a number of N DPOAE measurements of a stimulation frequency pair with respectively different level pairs in a population (p) of a population of normally hearing subjects, automatically presenting n different level pairs of a stimulation frequency pair via tone output means to an individual and detecting the corresponding DPOAE's of the individual via tone recording means, wherein at least the first level pair is predefined, iteratively adapting the model function to the measured n DPOAE's until an individual function is obtained with individual parameters of a DPOAE level map of the individual, outputting the individual function and/or its individual parameters.Type: GrantFiled: March 14, 2017Date of Patent: June 1, 2021Assignee: EBERHARD-KARLS-UNIVERSITÄT TÜBINGENInventors: Ernst Dalhoff, Dennis Zelle
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Patent number: 10906952Abstract: The present invention relates to fusion proteins comprising a binding protein and an IL-15 polypeptide as well as uses thereof, pharmaceutical compositions comprising such fusion proteins and a method for producing such fusion proteins.Type: GrantFiled: March 7, 2016Date of Patent: February 2, 2021Assignees: DEUTSCHES KREBSFORSCHUNGSZENTRUM, EBERHARD KARLS UNIVERSITÄT TÜBINGENInventors: Jung Gundram, Helmut Salih, Cornelia Lindner, Berit Lochmann
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Publication number: 20200239843Abstract: The present invention is in the field of the cultivation of biological cells and tissues with organ-like function on a microphysiological scale and provides a method for the microphysiological co-cultivation of 3D organoid tissue and at least one 2D cell layer.Type: ApplicationFiled: October 1, 2018Publication date: July 30, 2020Applicants: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V., EBERHARD KARLS UNIVERSITÄT TÜBINGENInventors: Peter LOSKILL, Christopher PROBST, Stefan LIEBAU, Kevin ACHBERGER, Jasmin HADERSPECK
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Patent number: 10590432Abstract: The invention relates to a plant having increased resistance to pathogens, wherein the protein SOBIR1 from Arabidopsis thaliana or a homologous protein, which is capable of interacting with at least one of the PRR receptor proteins RLP30 or RLP1, and at least one of the PRR receptor proteins RLP30 or RLP1 are overexpressed in comparison with the wild-type plant or are newly synthesized. The pathogens are preferably fungi, in particular from the genus Sclerotinia, and bacteria, in particular from the genus Xanthomonas. The invention further relates to a method for producing a plant having increased resistance to pathogens.Type: GrantFiled: June 5, 2014Date of Patent: March 17, 2020Assignee: EBERHARD KARLS UNIVERSITÄT TÜBINGENInventors: Andrea Gust, Malou Fraiture, Weiguo Zhang, Frédéric Brunner
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Patent number: 10561347Abstract: In a method for examining the faculty of hearing for at least one ear of a mammal, in which growth curves are determined on the basis of the measurement of DPOAE's evoked by pairs of excitation signals (f1, f2) for different excitation frequencies f2, the ear is presented with first excitation signals with a first excitation frequency f1 and a first noise level L1 and secondary excitation signals with a second excitation frequency f2 and a second noise level L2. Pulse pairs with a first pulse of the first excitation signal and a second pulse of the second excitation signal are presented in the ear, and the DPOAE's evoked thereby are captured and evaluated. A set of at least two different pulse pairs with different second excitation frequencies f2 is presented in one block that is repeated several times during a measuring period.Type: GrantFiled: June 19, 2015Date of Patent: February 18, 2020Assignee: Eberhard Karls Universitat TubingenInventors: Ernst Dalhoff, Dennis Zelle
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Publication number: 20190376051Abstract: The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.Type: ApplicationFiled: April 30, 2019Publication date: December 12, 2019Applicants: Eberhard Karls Universität Tübingen Medizinische Fakultät, Helmholtz-Zentrum für Infektionsforschung GmbH für das Helmholtz-Institut für PharmazeutischeInventors: Michael KORMANN, Lauren Mays WEDDLE, Claus-Michael LEHR, Brigitta LORETZ, Emad MALAEKSEFAT
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Publication number: 20190158966Abstract: In a hearing aid (26) that can be inserted into the ear canal (12) of a patient, comprising an actuator (31) effecting a mechanical stimulation of the tympanic membrane (14), the actuator (31) comprises an inner surface (32) associated with the tympanic membrane (14) and an outer surface (42) associated with the ear canal (12) and is configured as an areal disk actuator, whose deformation stimulates the tympanic membrane (14) by areal deformation. On the actuator (31) at a distance from the outer surface (42) a cover plate (43) is arranged which together with the outer surface (42) delimits a preferably lenticular cavity (48).Type: ApplicationFiled: January 17, 2019Publication date: May 23, 2019Applicant: EBERHARD KARLS UNIVERSITAT TUBINGEN MEDIZINISCHE FAKULTATInventors: Ernst DALHOFF, Hans-Peter ZENNER
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Patent number: 10285939Abstract: The invention relates to compositions and methods that utilize polymeric nanoparticles to deliver a therapeutic compound to ocular cells or ocular tissue. Provided is a drug-loaded micelle comprising self-assembled amphiphilic biopolymers, such as hydrophobically modified nucleic acids or polypeptides, for use as ophthalmic drug delivery system. Also provided are ophthalmic compositions and methods for preventing or treating an ophthalmic disease.Type: GrantFiled: September 17, 2014Date of Patent: May 14, 2019Assignee: Eberhard Karls Universität Tübingen Medizinische FakultätInventors: Andreas Herrmann, Jan Willem De Vries, Martin Stephan Spitzer, Sven Oliver Schnichels