Abstract: The present invention relates to a method of treating movement disorders of a living being, a method of treating refractory gait disturbances of a human Parkinson's disease patient being affected by gait disturbances, and an apparatus for deep brain stimulation (DBS) of a living being affected by movement disorders.

Abstract: The present invention relates to a nucleic acid molecule, a genetic construct, siRNA molecules and a composition which comprises the nucleic acid molecule and/or the genetic construct and/or the siRNA molecules and can be used for inhibition of the expression of endothelial adhesion molecules. The invention also relates to a device, which is coated with the aforementioned molecules, the composition or the construct, or contains them. The present invention further relates to a corresponding use of the nucleic acid molecule, of the genetic construct or of the siRNA molecules and a method of inhibition of the expression of adhesion molecules and a method of vessel grafting, lung transplantation, treatment of lung transplants, and a method of treatment of the open heart within the scope of cardioplegia.

Abstract: The present invention relates to a method for the in vitro determination of the presence of or a predisposition of a patient to the development of cancer. In the method according to the invention, the presence of a marker is determined in a biological sample of the patient, said marker being selected from a) the amino acid sequence SEQ ID No. 2 from the sequence protocol that is provided, or b) a nucleic acid that encodes the amino acid sequence with the SEQ ID No. 2. The invention further relates to the amino acid and the encoding nucleic acid and to the use thereof in diagnostics and for molecular therapeutic approaches.

Abstract: It is disclosed a system and method (12) for determining a property map (82) of an object, particularly a human being, based on at least a first image (84), particularly an magnetic resonance (MR) image, of the object. In the method (12), a structure of reference pairs is defined in a first step (96), wherein each reference pair (16-26) comprises at least two entries (62). The first entry represents a property value, particularly an attenuation value. The second entry (62) preferably represents a group of image points (67) belonging together, which is extracted particularly from MR images (28) and comprises an interesting image point corresponding to the property value. In another step (98) of the method (12) a plurality of training pairs (16-26) is provided. A structure of the training pairs (16-26) corresponds to the structure of reference pairs, and the entries of respective training pairs (16-26) are known.

Abstract: The present invention relates to a method for diagnosing and/or predicting the development of neurodegenerative diseases; in the method, white blood cells are isolated and enriched or cultivated for forming colony-forming units, wherein CFU-M and other CFU are formed. Subsequently, the relative number of CFU-M formed in the previous cultivation(/enrichment step relative to the other CFUs formed are determined.

Abstract: The present invention relates to a therapeutic or/and diagnostic substance. Furthermore it relates to an expression vector, to a composition comprising the afore-mentioned substance or/and the afore-mentioned expression vector, a method for diagnosing a tumor disease or/and an infectious disease in a living being, as well as to a method for the treatment of a tumor disease or/and of an infection in a living being.

Abstract: A device for treating milk contained in a container is disclosed. The device comprises at least one heat source that comprises an air bath, a device for setting the container in motion and exposing the container to the heat source for a defined period of time, and a cooling source for cooling the milk.

Abstract: A method for treating milk, wherein milk is short-term heated in a container. At least during the heating, the container is set in motion in such a way that a milk film forms on the inner wall of the container. A device for carrying out the method is likewise described (FIG. 1).

Abstract: The present invention relates to Bartonella henselae as a component of a pharmaceutical composition for the modulation of the angiogenesis; a nucleic acid molecule that is derived from the gene encoding the Bartonella henselae adhesin A protein (BadA), a vector comprising said nucleic acid molecule; a host containing said nucleic acid molecule or said vector; a (poly)peptide encoded by said nucleic acid molecule; a composition comprising Bartonella henselae bacteria; a composition comprising aforesaid (poly)peptide; a method for treating a human or animal being in need of the modulation of the angiogenesis, a method for detecting an infection by Bartonella in a human or animal being, as well as a method for immunizing a cat.

Abstract: Monoclonal antibodies which bind specifically to the extracellular domain of the SIRP cell surface glycoproteins, and which, in some cases, block the interaction of SIRP with the surface molecule CD47, are described.

Abstract: A method for detecting human papillomaviruses (HPV) in biological material is described, in which method nucleic acids are extracted/isolated from biological material and HPV-specific DNA is detected in the isolated nucleic acids. This method uses at least one of the nucleotide sequences SEQ ID No. 1 or SEQ ID No. 2 from the enclosed sequence listing or sequences which bind to sequences to which one of the sequences SEQ ID No. 1 or SEQ ID No. 2 binds or sequences which are complementary to the abovementioned sequences.

Abstract: A retina implant including a chip adapted to be implanted into the interior of eye in subretinal contact with the retina. The chip has a plurality of pixel elements on a side thereof facing the lens for receiving an image projected into the retina and a plurality of electrodes for stimulating retina cells. The implants further includes a receiver coil for inductively coupling thereinto electromagnetic energy. The receiver coil coupled to a means for converting an alternating voltage induced into the receiver coil in a direct voltage suited for supplying the chip. The receiver coil is configured as a component separate from the chip, and for being positioned on the eye ball outside the sclera. The chip is connected to the receiver coil via a connecting lead which, in the implanted condition interconnects the interior and the exterior of the eye ball.

Abstract: A retina implant, comprises a surface and a plurality of pixel elements disposed on the surface for receiving and converting incoming light energy into electric energy. At least one amplifier is provided in the implant, and a plurality of stimulation electrodes supplied via the at least one amplifier as a function of signals received by the pixel elements. At least one light-sensitive reference element is coupled with the at least one amplifier for controlling amplification thereof as a function of light energy impinging on the at least one reference element.

Abstract: An operation kit is provided for access into the subretinal region of the eye. The kit comprises an elongated flat body of soft material, which can be inserted into the subretinal region from the side through an incision in the sclera. The body is formed as a strip, whose one surface is configured as a guiding surface for a medical device, for example for implanting a microphotodiode chip.

Abstract: For the detection of fungal cells in clinical material fungal DNA is extracted from whole blood and the extracted fungal DNA is then detected. From this detection, a fungal infection can be concluded. For further diagnosis, the fungal species are then determined from the extracted fungal DNA. The method for extraction of the fungal DNA from whole blood comprises the isolation of predominantly intact fungal cells from the whole blood and the extraction of DNA from the isolated fungal cells. For detection of fungal DNA, at least one segment of the fungal DNA to be detected is amplified, then the amplification products are detected. For further identification of the fungal species, nucleotide sequence segments being characteristic for the fungal species are detected.

Abstract: The present invention relates to a monoclonal antibody binding an antigen on the megakaryocytic cell line UT-7. The invention further relates to hybridoma cells producing such an antibody.