Abstract: A growth control device includes a bone plate having a stepped profile defined by a first level, a second level and an intermediate ramp connecting the first and second levels. The first level includes a first threaded hole for receiving a first bone fastener and the second level includes a second threaded hole for receiving a second bone fastener. The bone plate includes a proximal pair of side female notches, a distal pair of side female notches, a proximal guide hole and a distal guide hole.

Abstract: A growth control device includes a bone plate having a stepped profile defined by a first level, a second level and an intermediate ramp connecting the first and second levels. The first level includes a first threaded hole for receiving a first bone fastener and the second level includes a second threaded hole for receiving a second bone fastener. The bone plate includes a proximal pair of side female notches, a distal pair of side female notches, a proximal guide hole and a distal guide hole.

Abstract: An expandable spinal implant device for supporting vertebral bodies can include first and second body members and first and second expansion mechanisms. The body members can each have a first end positionable toward one of the vertebral bodies and can each define a hollow interior. The expansion mechanisms can be spaced apart from each other and can include a first drive shaft and a second drive shaft, respectively. The first and second drive shafts can each have a gear member fixedly coupled thereto. Each drive shaft can be threadably engaged at a first side to the first body member and at a second side to the second body member. The expansion mechanisms can be operable to effect axial displacement of the first body member relative to the second body member by rotationally driving the gear members of the first and second drive shafts.

Abstract: A bone fixation assembly is provided and may include a fixation member defining at least one aperture. At least two locking features may be circumferentially spaced around an inner perimeter of the at least one aperture and may include a first end and a second end. The at least two locking features may each include a longitudinal axis extending substantially perpendicular to an axis extending through the at least one aperture. A fastener may include at least two discrete locking members respectively received in the at least two locking features at the first end. The at least two discrete locking members may be circumferentially spaced around an outer perimeter of the fastener, may extend from an outer surface of a head of the fastener, and may be received within the first end in an unlocked state and rotated from the first end to the second end in a locked state.

Abstract: An orthopedic device includes a targeting member, an elongated guiding member, and an adjustment member. The targeting member has an elongated body along a first longitudinal axis and can be coupled to an intramedullary implant such that the first longitudinal axis is parallel to the intramedullary implant. The targeting member includes a first bore extending along a second longitudinal axis t1hrough the elongated body, the first bore having a cross-section elongated in the direction of the first longitudinal axis. The first and second longitudinal axes define a first plane. The elongated guiding member passes through the first bore and is pivotable relative to the first longitudinal axis. The adjustment member is coupled to the elongated body and operable to change an orientation of the guiding member relative to the first longitudinal axis in the first plane.

Abstract: An instrument for multi-level percutaneous spinal procedures. The instrument can include a curved rack having length adapted for at least substantially spanning first and second vertebrae and one or more intermediate vertebrae between the first and second vertebrae. The instrument can include first and second towers correspondingly engageable with the first and second vertebrae, and one or more intermediate towers engageable with the intermediate vertebrae. Further, the instrument can include first and second arms adapted for movably connecting the first and second towers to the rack, and one or more intermediate arms adapted for movably connecting the intermediate tower to the rack.

Abstract: An intramedullary fixation device includes an intramedullary implant having a longitudinal bore along a longitudinal axis, a two-component compression device and a two-component locking device, both devices preassembled in the longitudinal bore. The intramedullary implant includes an elongated slot and first and second apertures transversely crossing the longitudinal axis. The compression device is movable along the longitudinal axis and defines an end opening aligned with the elongated slot of the intramedullary implant. The locking device includes first and second openings aligned along the first and second apertures of the intramedullary implant.

Abstract: Methods of modifying stem cells and compositions of modified stem cells, in particular mesenchymal stem cells, using electric or electromagnetic fields. In various embodiments, the present invention's methods are for the treatment of a human or other mammal subject in need thereof, comprising providing an in vitro culture comprising mesenchymal stem cells, administering an electric stimulation to the in vitro culture, and implanting the mesenchymal stem cells into the subject. Methods also include treatment of a human or other mammal subject, comprising implanting mesenchymal stem cells into the subject, and administering an electric stimulation to the mesenchymal stem cells in situ. Other embodiments include methods of administering electric stimulation in conjunction with growth factors to stem cells.

Abstract: Methods and devices for treatment of osteonecrosis of the femoral head with core decompression include a dowel adapted for placement into a core decompression channel of a femoral head. A cathode at the distal end of the dowel provides electrical stimulation of bone growth in the femoral head. A method of treating osteonecrosis of the femoral head involves placing a dowel having a cathode thereon into a core decompression channel of a femoral head in a state of osteonecrosis. Electrical current is supplied to the cathode for electrical stimulation of bone growth in the femoral head.

Abstract: A rod coercer for use in spinal fixation procedures is provided. The rod coercer can be pivoted in a first direction to fixedly grip an implant, and pivoted in a second direction to reduce a rod into the implant. In one embodiment, the rod coercer includes first and second articulating handle branches, first and second rod contacting arms extending from the first and second handle branches, first and second implant gripping arms pivotally interconnected with the first and second handle branches, and means for releasably locking the handle branches and the implant gripping arms in a closed and locked position. In another embodiment, the rod coercer includes a single handle having first and second implant gripping arms connected by a bridge and pivotally attached to the handle, and spring-loaded implant gripping arms for gripping sides of an implant.

Abstract: A rod coercer for use in spinal fixation procedures is provided. The rod coercer can be pivoted in a first direction to fixedly grip an implant, and pivoted in a second direction to reduce a rod into the implant. In one embodiment, the rod coercer includes first and second articulating forceps branches, first and second rod contacting arms extending from the first and second forceps branches, and first and second implant gripping arms pivotally interconnected with the rod contacting arms. In another embodiment, the rod coercer includes forceps branches which each include upper and lower forceps branches which pivot with respect to each other, and a rod contacting arm interconnected with one of the forceps branches. In another embodiment, the rod coercer includes pivotable implant gripping arms and a rod contacting arm driven by one of the forceps branches.

Abstract: Disclosed is a method for producing a three-dimensional composite structure and a method for producing the mold for the three-dimensional composite structure. The mold is formed of at least one rigid die member and a second thermoplastic die member. The second thermoplastic die member is formed by coupling a rubber flexible pattern to a surface of the first die member. Vacuum or pressure is applied to a heated thermoplastic sheet to cause the heated thermoplastic sheet to deform about the flexible pattern, thereby forming the second die. Strips of reinforced polymer thermoset pre-preg material are then positioned within the cavities formed by the flexible pattern and are allowed to cure. Optionally, heat, pressure, and vacuum may be applied to the mold construction to facilitate the curing of the thermoset materials.

Abstract: The present teachings provide one or more surgical instruments for repairing damaged tissue, such as in the case of a vertebral compression fracture. The present teachings can provide a bone cement system. The system can include a housing, which can define at least a throughbore that can extend from a proximal end to a distal end of the housing. The system can also include a dispenser housing received in the throughbore of the housing that is adapted to receive a bone cement. The system can include a plunger, which can be releasably coupled to the proximal end of the housing and received into the dispenser housing so that movement of the plunger can dispense the bone cement. The system can also include a pressure release system, which can be coupled to the housing and can be movable to release pressure within the dispenser housing without moving the plunger.

Abstract: The present teachings provide one or more surgical implements for repairing damaged tissue, such as in the case of a spinal fixation procedure. A bone anchor is provided. The anchor can include a bone fastener. The bone fastener can include a head and a second end adapted to engage an anatomy. The bone fastener can extend along a longitudinal axis. The anchor can also include a coupling arrangement coupled to the head of the bone fastener so that the bone fastener is rotatable about the longitudinal axis to define a first plane of motion. The anchor can further include a saddle, which can be coupled to the coupling arrangement. The saddle can be movable relative to at least one of the bone fastener and the coupling arrangement to define a second plane of motion.

Abstract: Implantable pliable bone blocks comprising a solid block of cortical bone characterized by a length, width and thickness, having a first and a second face on opposite sides of the block. The first and second faces have a plurality slot features. The angle of incidence of the slot features of the first face and the x-axis and the angle of incidence of the slot features of the second face and the x-axis (a2) are such that the slots would intersect if they were in the same plane. Methods are provided for making implantable pliable bone blocks.

Abstract: A tensioner for tensioning a wire/cable coupled to an external orthopedic device. The tensioner can include a housing, an outer sleeve movable relative to the housing, a movable tension actuator handle operable to move the outer sleeve relative to the housing, and a plurality of movable jaws supported in the outer sleeve. The jaws can move between an open position for receiving the wire/cable and a closed position for gripping the wire/cable when the tension actuator handle is operated.

Abstract: A method for treatment of degenerative disc disease using capacitively coupled electrical stimulation. In one embodiment, a subject diagnosed as having degenerative disc disease is treated by placing first and second electrodes on the subject's body at the site of an identified disc in a state of degenerative disc disease, and applying an electric field to the identified disc via the first and second electrodes with the intent to treat the degenerative disc disease. The electric field is created with an electrical signal having a frequency within a range of 20 to 100 kHz and having a symmetrical waveform with an amplitude within a range of 0.1 to 20 volts peak-to-peak, preferably a frequency of approximately 60 kHz and an amplitude of approximately 5 volts peak-to-peak.

Abstract: The present teachings provide one or more surgical implements for repairing damaged tissue, such as in the case of a fixation procedure. For example, a system is provided that includes a bone plate having a first plurality of apertures and a targeting arm having a second plurality of apertures. Each of the second plurality of apertures of the targeting arm are configured for targeting of a bone fastener to one of first plurality of apertures. An imaginary targeting line extends from a first aperture of the first plurality of apertures to a first aperture of the second plurality of apertures. The system includes a mounting member, which includes a first end secured to the bone plate and a second end secured to the targeting arm. The second end of the mounting member is offset from the first end such that the second end is spaced from the imaginary targeting line.

Abstract: A bone fixation assembly and associated method. The bone fixation assembly includes a bone fastener having a head and a bone-engaging portion, a receiver defining an opening along a first axis for receiving the bone fastener at a variable angle, and at least one supporting augment coupled to the bone fastener. The receiver has an inner articulation surface at a lower portion of the opening and matingly articulates with the supporting augment.