Patents Assigned to EBR Systems, Inc.
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Patent number: 11925812Abstract: The present technology generally includes devices, systems, and methods for providing electrical stimulation to the left ventricle of a human heart in a patient suffering from Left Bundle Branch Block (LBBB). In particular, the present technology includes an implantable receiver-stimulator and an implantable controller-transmitter for leadless electrical stimulation of the heart. The receiver-stimulator can include one or more sensors capable of detecting the electrical conduction of the heart and the receiver-stimulator can be configured to pace the stimulation of the left ventricle based off the sensed electrical conduction to achieve synchronization of the left and right ventricles.Type: GrantFiled: February 8, 2022Date of Patent: March 12, 2024Assignee: EBR SYSTEMS, INC.Inventors: Steven Kim, Nathaniel Parker Willis
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Patent number: 11752352Abstract: Delivery of an implantable wireless receiver-stimulator (R-S) into the heart using delivery catheter is described. R-S comprises a cathode and an anode and wirelessly receives and converts energy, such as acoustic ultrasound energy, to electrical energy to stimulate the heart. Conductive wires routed through the delivery system temporarily connect R-S electrodes to external monitor and pacing controller. R-S comprises a first temporary electrical connection from the catheter to the cathode, and a second temporary electrical connection from the catheter to the anode. Temporary electrical connections allow external monitoring of heart's electrical activity as sensed by R-S electrodes to determine tissue viability for excitation as well as to assess energy conversion efficiency.Type: GrantFiled: May 20, 2020Date of Patent: September 12, 2023Assignee: EBR Systems, Inc.Inventors: David F. Moore, Mark W. Cowan, Nathaniel Parker Willis
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Patent number: 11712572Abstract: A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue.Type: GrantFiled: September 24, 2020Date of Patent: August 1, 2023Assignee: EBR Systems, Inc.Inventors: David F. Moore, Paul Mohr, N. Parker Willis, Axel F. Brisken
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Patent number: 11654287Abstract: The present technology is generally directed to implantable medical device systems configured to provide cardiac resynchronization therapy. In some embodiments, the implantable medical device system comprises a housing, electrodes carried by the housing, a transducer configured to produce input voltage signals in response to ultrasound energy, and a circuit configured to provide, via an electrical pathway, output voltage signals based on the input voltage signals. The circuit comprises a movable switch, and a slew rate detector configured to detect whether a voltage rate of an individual pulse of the input voltage signals exceeds a predetermined threshold voltage rate. The circuit is configured to move the switch to an open position in response to the detected voltage rate exceeding the predetermined threshold voltage rate.Type: GrantFiled: August 30, 2019Date of Patent: May 23, 2023Assignee: EBR Systems, Inc.Inventor: Parker N. Willis
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Patent number: 11452879Abstract: Method and systems for optimizing acoustic energy transmission in implantable devices are disclosed. Transducer elements transmit acoustic locator signals towards a receiver assembly, and the receiver responds with a location signal. The location signal can reveal information related to the location of the receiver and the efficiency of the transmitted acoustic beam received by the receiver. This information enables the transmitter to target the receiver and optimize the acoustic energy transfer between the transmitter and the receiver. The energy can be used for therapeutic purposes, for example, stimulating tissue or for diagnostic purposes.Type: GrantFiled: October 15, 2019Date of Patent: September 27, 2022Assignee: EBR Systems, Inc.Inventors: N. Parker Willis, Axel F. Brisken, Mark W. Cowan, Michael Pare, Robert Fowler, James Brennan
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Patent number: 11433243Abstract: Systems, devices, and methods for tracking and determining the motion of a cardiac implant is disclosed. The motion of the implant is determined by transmitting acoustic energy to a tissue location using an acoustic controller-transmitter comprising an array of acoustic transducers; wherein the implant is configured to convert the transmitted acoustic energy to electrical energy; and the tracking is achieved by determining the electrical energy delivered to the tissue throughout one or more cardiac cycles in order to create a motion profile of the cardiac implant.Type: GrantFiled: August 1, 2018Date of Patent: September 6, 2022Assignee: EBR Systems, Inc.Inventor: N. Parker Willis
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Patent number: 11376439Abstract: The present invention relies on a controller-transmitter device to deliver ultrasound energy into cardiac tissue in order to directly improve cardiac function and/or to energize one or more implanted receiver-stimulator devices that transduce the ultrasound energy to electrical energy to perform excitatory and/or non-excitatory treatments for heart failure. The acoustic energy can be applied as a single burst or as multiple bursts.Type: GrantFiled: January 16, 2019Date of Patent: July 5, 2022Assignee: EBR Systems, Inc.Inventors: Debra S. Echt, Richard E. Riley, Mark W. Cowan, Axel F. Brisken
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Patent number: 11266845Abstract: The present technology generally includes devices, systems, and methods for providing electrical stimulation to the left ventricle of a human heart in a patient suffering from Left Bundle Branch Block (LBBB). In particular, the present technology includes an implantable receiver-stimulator and an implantable controller-transmitter for leadless electrical stimulation of the heart. The receiver-stimulator can include one or more sensors capable of detecting the electrical conduction of the heart and the receiver-stimulator can be configured to pace the stimulation of the left ventricle based off the sensed electrical conduction to achieve synchronization of the left and right ventricles.Type: GrantFiled: January 27, 2020Date of Patent: March 8, 2022Assignee: EBR Systems, Inc.Inventors: Steven Kim, Parker Willis
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Patent number: 10806938Abstract: Receiver-stimulator with folded or rolled up assembly of piezoelectric components, causing the receiver-stimulator to operate with a high degree of isotropy are disclosed. The receiver-stimulator comprises piezoelectric components, rectifier circuitry, and at least two stimulation electrodes. Isotropy allows the receiver-stimulator to be implanted with less concern regarding the orientation relative the transmitted acoustic field from an acoustic energy source.Type: GrantFiled: July 31, 2018Date of Patent: October 20, 2020Assignee: EBR Systems, Inc.Inventors: David F. Moore, Paul Mohr, N. Parker Willis, Axel F. Brisken
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Patent number: 10688307Abstract: Delivery of an implantable wireless receiver-stimulator (R-S) into the heart using delivery catheter is described. R-S comprises a cathode and an anode and wirelessly receives and converts energy, such as acoustic ultrasound energy, to electrical energy to stimulate the heart. Conductive wires routed through the delivery system temporarily connect R-S electrodes to external monitor and pacing controller. R-S comprises a first temporary electrical connection from the catheter to the cathode, and a second temporary electrical connection from the catheter to the anode. Temporary electrical connections allow external monitoring of heart's electrical activity as sensed by R-S electrodes to determine tissue viability for excitation as well as to assess energy conversion efficiency.Type: GrantFiled: January 23, 2018Date of Patent: June 23, 2020Assignee: EBR Systems, Inc.Inventors: David F. Moore, Mark W. Cowan, N. Parker Willis
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Patent number: 10576287Abstract: A system for delivering an electrical stimulation pulse to tissue comprises a controller-transmitter and a receiver-stimulator. The controller-transmitter includes circuitry having an energy storage capacitor. The capacitance of the energy storage capacitor is adjusted to improve the efficiency of energy delivered from the receiver-stimulator to tissue by modifying the geometry of an acoustic drive burst from the controller-transmitter.Type: GrantFiled: December 11, 2017Date of Patent: March 3, 2020Assignee: EBR Systems, Inc.Inventor: Mark W. Cowan
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Patent number: 10512785Abstract: A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue. Furthermore, the controller-transmitter estimates the output voltage that is delivered to the tissue by the implanted receiver-stimulator. The controller-transmitter measures a query spike voltage resulting from the electrical energy delivered to the tissue by the receiver-stimulator, and computes a ratio of the predetermined maximum output voltage and a maximum query spike voltage. The maximum query spike voltage is computed by detecting a query spike voltage plateau.Type: GrantFiled: January 17, 2019Date of Patent: December 24, 2019Assignee: EBR Systems, Inc.Inventors: David F. Moore, Paul Mohr, N. Parker Willis, Axel F. Brisken
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Publication number: 20190336776Abstract: Systems and methods are disclosed to stimulate tissue to treat medical conditions involving tissues such as the bone, spine, stomach, nerves, brain and the cochlea. The disclosed invention uses electrical stimulation of the tissue, where vibrational (or acoustic) energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined tissue sites. The vibrational energy is generated by a controller-transmitter, which could be either implanted or located externally. The vibrational energy is received by a receiver-stimulator, which could be located at or close to the stimulation site.Type: ApplicationFiled: October 29, 2018Publication date: November 7, 2019Applicant: EBR Systems, Inc.Inventors: Mark W. Cowan, Richard E. Riley, Axel F. Brisken, Debra S. Echt
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Patent number: 10456588Abstract: Method and systems for optimizing acoustic energy transmission in implantable devices are disclosed. Transducer elements transmit acoustic locator signals towards a receiver assembly, and the receiver responds with a location signal. The location signal can reveal information related to the location of the receiver and the efficiency of the transmitted acoustic beam received by the receiver. This information enables the transmitter to target the receiver and optimize the acoustic energy transfer between the transmitter and the receiver. The energy can be used for therapeutic purposes, for example, stimulating tissue or for diagnostic purposes.Type: GrantFiled: August 21, 2018Date of Patent: October 29, 2019Assignee: EBR Systems, Inc.Inventors: N. Parker Willis, Axel F. Brisken, Mark W. Cowan, Michael Pare, Robert Fowler, James Brennan
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Patent number: 10207115Abstract: The present invention relies on a controller-transmitter device to deliver ultrasound energy into cardiac tissue in order to directly improve cardiac function and/or to energize one or more implanted receiver-stimulator devices that transduce the ultrasound energy to electrical energy to perform excitatory and/or non-excitatory treatments for heart failure. The acoustic energy can be applied as a single burst or as multiple bursts.Type: GrantFiled: April 26, 2016Date of Patent: February 19, 2019Assignee: EBR Systems, Inc.Inventors: Debra S. Echt, Richard E. Riley, Mark W. Cowan, Axel F. Brisken
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Publication number: 20180353763Abstract: Method and systems for optimizing acoustic energy transmission in implantable devices are disclosed. Transducer elements transmit acoustic locator signals towards a receiver assembly, and the receiver responds with a location signal. The location signal can reveal information related to the location of the receiver and the efficiency of the transmitted acoustic beam received by the receiver. This information enables the transmitter to target the receiver and optimize the acoustic energy transfer between the transmitter and the receiver. The energy can be used for therapeutic purposes, for example, stimulating tissue or for diagnostic purposes.Type: ApplicationFiled: August 21, 2018Publication date: December 13, 2018Applicant: EBR Systems, Inc.Inventors: N. Parker Willis, Axel F. Brisken, Mark W. Cowan, Michael Pare, Robert Fowler, James Brennan
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Publication number: 20180345026Abstract: Receiver-stimulator with folded or rolled up assembly of piezoelectric components, causing the receiver-stimulator to operate with a high degree of isotropy are disclosed. The receiver-stimulator comprises piezoelectric components, rectifier circuitry, and at least two stimulation electrodes. Isotropy allows the receiver-stimulator to be implanted with less concern regarding the orientation relative the transmitted acoustic field from an acoustic energy source.Type: ApplicationFiled: July 31, 2018Publication date: December 6, 2018Applicant: EBR Systems, Inc.Inventors: David F. Moore, Paul Mohr, N. Parker Willis, Axel F. Brisken
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Patent number: 10143850Abstract: Systems and methods are disclosed to stimulate tissue to treat medical conditions involving tissues such as the bone, spine, stomach, nerves, brain and the cochlea. The disclosed invention uses electrical stimulation of the tissue, where vibrational (or acoustic) energy from a source is received by an implanted device and converted to electrical energy and the converted electrical energy is used by implanted electrodes to stimulate the pre-determined tissue sites. The vibrational energy is generated by a controller-transmitter, which could be either implanted or located externally. The vibrational energy is received by a receiver-stimulator, which could be located at or close to the stimulation site.Type: GrantFiled: August 29, 2016Date of Patent: December 4, 2018Assignee: EBR Systems, Inc.Inventors: Mark W. Cowan, Richard E. Riley, Axel F. Brisken, Debra S. Echt
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Publication number: 20180280704Abstract: Delivery of an implantable wireless receiver-stimulator (R-S) into the heart using delivery catheter is described. R-S comprises a cathode and an anode and wirelessly receives and converts energy, such as acoustic ultrasound energy, to electrical energy to stimulate the heart. Conductive wires routed through the delivery system temporarily connect R-S electrodes to external monitor and pacing controller. R-S comprises a first temporary electrical connection from the catheter to the cathode, and a second temporary electrical connection from the catheter to the anode. Temporary electrical connections allow external monitoring of heart's electrical activity as sensed by R-S electrodes to determine tissue viability for excitation as well as to assess energy conversion efficiency.Type: ApplicationFiled: January 23, 2018Publication date: October 4, 2018Applicant: EBR Systems, Inc.Inventors: David F. Moore, Mark W. Cowan, N. Parker Willis
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Patent number: 10080903Abstract: Method and systems for optimizing acoustic energy transmission in implantable devices are disclosed. Transducer elements transmit acoustic locator signals towards a receiver assembly, and the receiver responds with a location signal. The location signal can reveal information related to the location of the receiver and the efficiency of the transmitted acoustic beam received by the receiver. This information enables the transmitter to target the receiver and optimize the acoustic energy transfer between the transmitter and the receiver. The energy can be used for therapeutic purposes, for example, stimulating tissue or for diagnostic purposes.Type: GrantFiled: March 20, 2014Date of Patent: September 25, 2018Assignee: EBR SYSTEMS, INC.Inventors: N. Parker Willis, Axel F. Brisken, Mark W. Cowan, Michael Pare, Robert Fowler, James Brennan