Abstract: The present invention provides methods for identifying monobactams with anti-PBP2a activity. The method involves the selection of RNA biocatalysts that promote the formation of monobactams with anti-PBP2a activity from component reactants. The invention also provides novel monobactams with anti-PBP2a activity identified by these methods. The invention also provides RNA biocatalysts that are capable of catalyzing the formation of monobactams from component reactants.
Type:
Application
Filed:
December 18, 2002
Publication date:
June 9, 2005
Applicant:
EC Technology, LLC
Inventors:
Bruce Eaton, Ted Tarasow, Dan Nieuwlandt, Torin Dewey