Patents Assigned to Echelon Biosciences Incorporated
  • Compounds and methods of use thereof for assaying lysophospholipase D activity
    Patent number: 7989663
    Abstract: Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening (HTS) for identification of potential inhibitors of lysoPLD activity.
    Type: Grant
    Filed: October 28, 2008
    Date of Patent: August 2, 2011
    Assignee: Echelon Biosciences Incorporated
    Inventors: Colin Ferguson, Glenn Prestwich
  • Compounds and methods of use thereof for assaying lysophospholipase D activity
    Publication number: 20100260682
    Abstract: Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening (HTS) for identification of potential inhibitors of lysoPLD activity.
    Type: Application
    Filed: May 12, 2010
    Publication date: October 14, 2010
    Applicant: Echelon Biosciences Incorporated
    Inventors: Colin Ferguson, Glenn Prestwich, Damian Madan
  • Compounds and methods of use thereof for assaying lysophospholipase D activity
    Publication number: 20090068697
    Abstract: Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening (HTS) for identification of potential inhibitors of lysoPLD activity.
    Type: Application
    Filed: October 28, 2008
    Publication date: March 12, 2009
    Applicant: Echelon Biosciences Incorporated
    Inventors: Colin Ferguson, Glenn Prestwich
  • Compounds and methods of use thereof for assaying lysophospholipase D activity
    Patent number: 7459285
    Abstract: Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening(HTS) for identification of potential inhibitors of lysoPLD activity.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: December 2, 2008
    Assignee: Echelon Biosciences Incorporated
    Inventors: Colin Ferguson, Glenn Prestwich
  • Compounds and methods of use thereof for assaying lysophospholipase D activity
    Publication number: 20040171096
    Abstract: Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening(HTS) for identification of potential inhibitors of lysoPLD activity.
    Type: Application
    Filed: December 9, 2003
    Publication date: September 2, 2004
    Applicant: Echelon Biosciences Incorporated
    Inventors: Colin Ferguson, Glenn Prestwich
  • Lipid phosphatase assays in disease and drug discovery
    Publication number: 20040096923
    Abstract: A lipid assay method, kit, and apparatus involving exposing a lipid detector protein containing a lipid recognition motif with a binding specificity for a product lipid of a lipid phosphatase, to a solution containing a substrate lipid of the lipid phosphatase; and determining whether the product lipid is present. The assay is preferably a competitive assay wherein the product lipid has a stronger affinity to the lipid detector protein than the substrate lipid. The lipid recognition motif is preferably a pleckstrin homology (PH) domain.
    Type: Application
    Filed: November 13, 2003
    Publication date: May 20, 2004
    Applicant: ECHELON BIOSCIENCES INCORPORATED
    Inventors: Beth E. Drees, Paul O. Neilsen, Angie M. Branch, Amber Weipert