Patents Assigned to Echo Therapeutics, Inc.
-
Patent number: 9572527Abstract: Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.Type: GrantFiled: January 22, 2013Date of Patent: February 21, 2017Assignee: Echo Therapeutics, Inc.Inventors: Han Chuang, Juan P. Eslava, James P. Hurley, Debashis Ghosh, Keith Krystyniak, Scott C. Kellogg
-
Patent number: 8870810Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.Type: GrantFiled: September 13, 2012Date of Patent: October 28, 2014Assignee: Echo Therapeutics, Inc.Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F Warner, Tuan A Elstrom
-
Patent number: 8812071Abstract: Transdermal analyte monitoring systems (TAMS) having increased longevity and improved analyte detection are described herein. Kits for use with the TAMS and methods of using the TAMS and kits are also described. In a preferred embodiment, the TAMS includes a protective, semi-permeable membrane covering the surface of the hydrogel. The protective, semi-permeable membrane contacts with the skin of a user and prevents contamination or fouling of the hydrogel. Optionally, the hydrogel comprises one or more humectants and/or an immobilized enzyme. In another preferred embodiment, the TAMS contains at least one channel or pocket for increasing the amount of oxygen provided to the hydrogel. In one embodiment, a method for improving analyte detection by the TAMS is provided. For example, after the skin porosity is increased by an appropriate pretreatment, a skin preparation wipe is applied to the treated skin area and then the TAMS is applied to the treated area.Type: GrantFiled: March 6, 2008Date of Patent: August 19, 2014Assignee: Echo Therapeutics, Inc.Inventors: Han Chuang, James P. Hurley, Joseph Kost
-
Publication number: 20130137951Abstract: Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. Preferably the feedback control mechanism is an internal feedback control mechanism. In this embodiment, the abrasive tip contains two electrodes, i.e. both the source electrode and the return electrode. In another embodiment, the feedback control mechanism is an external feedback control. In the preferred embodiment for external feedback control, the device contains a co-axial or concentric arrangement of the two electrodes. In this embodiment, the abrasive tip contains the source electrode and the return electrode is located at the proximal end of the hand piece.Type: ApplicationFiled: January 22, 2013Publication date: May 30, 2013Applicant: ECHO THERAPEUTICS, INC.Inventor: Echo Therapeutics, Inc.
-
Patent number: 8386027Abstract: Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.Type: GrantFiled: April 25, 2008Date of Patent: February 26, 2013Assignee: Echo Therapeutics, Inc.Inventors: Han Chuang, Juan P. Eslava, James P. Hurley, Debashis Ghosh, Keith Krystyniak, Scott C. Kellogg
-
Publication number: 20130035566Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.Type: ApplicationFiled: September 13, 2012Publication date: February 7, 2013Applicant: ECHO THERAPEUTICS, INC.Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F. Warner, Tuan A. Elstrom
-
Patent number: 8287483Abstract: According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area of the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.Type: GrantFiled: March 5, 2004Date of Patent: October 16, 2012Assignee: Echo Therapeutics, Inc.Inventors: Samir S. Mitragotri, Joseph Kost, Scott C. Kellogg, Nicholas F. Warner, Tuan A. Elstrom
-
Patent number: 8224414Abstract: The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system.Type: GrantFiled: September 13, 2005Date of Patent: July 17, 2012Assignee: Echo Therapeutics, Inc.Inventors: Scott C. Kellogg, Han Chuang
-
Publication number: 20110282327Abstract: A system and method for continuous non-invasive glucose monitoring is disclosed. According to one embodiment of the present invention, the method includes the steps of (1) contacting a remote device to an area of biological membrane having a permeability level, the remote device comprising a sensor and a transmitter; (2) extracting the at least one analyte through and out of the area of biological membrane and into the sensor; (3) generating an electrical signal representative of a level of the at least one analyte; (4) transmitting the electrical signal to a base device; (5) processing the electrical signal to determine the level of the at least one analyte; and (6) displaying the level of the at least one analyte in real time. The system includes a remote device that includes a sensor that generates an electrical signal representative of the concentration of the at least one analyte; and a transmitter that transmits the electrical signal.Type: ApplicationFiled: April 12, 2011Publication date: November 17, 2011Applicant: ECHO THERAPEUTICS, INC.Inventors: Scott C. KELLOGG, Han Chuang, Shikha Barman, Nick Warner
-
Patent number: 7963917Abstract: A system and method for continuous non-invasive glucose monitoring is disclosed. According to one embodiment of the present invention, the method includes the steps of (1) contacting a remote device to an area of biological membrane having a permeability level, the remote device comprising a sensor and a transmitter; (2) extracting the at least one analyte through and out of the area of biological membrane and into the sensor; (3) generating an electrical signal representative of a level of the at least one analyte; (4) transmitting the electrical signal to a base device; (5) processing the electrical signal to determine the level of the at least one analyte; and (6) displaying the level of the at least one analyte in real time. The system includes a remote device that includes a sensor that generates an electrical signal representative of the concentration of the at least one analyte; and a transmitter that transmits the electrical signal.Type: GrantFiled: December 5, 2005Date of Patent: June 21, 2011Assignee: Echo Therapeutics, Inc.Inventors: Scott Kellogg, Han Chuang, Shikha Barman, Nick Warner
-
Patent number: D689354Type: GrantFiled: May 19, 2011Date of Patent: September 10, 2013Assignee: Echo Therapeutics, Inc.Inventors: Harry Mitchell, Keith Krystyniak, Joseph O. St. Cyr, Steven Vordenberg, Christopher Labak, Jon Taylor, James Joseph Kennedy, III, Glenn Trainer, Benjamin Glace, Edward McLean, Wayne Menzie
-
Patent number: D714948Type: GrantFiled: May 24, 2013Date of Patent: October 7, 2014Assignee: Echo Therapeutics, Inc.Inventor: Lorenzo C. Vaccarella
-
Patent number: D719267Type: GrantFiled: May 22, 2013Date of Patent: December 9, 2014Assignee: Echo Therapeutics, Inc.Inventor: Lorenzo C. Vaccarella
-
Patent number: D779670Type: GrantFiled: June 15, 2015Date of Patent: February 21, 2017Assignee: Echo Therapeutics, Inc.Inventors: Keith E. Krystyniak, Stephen J. Perry