Abstract: An elastography device includes a probe with a single ultrasound transducer; or a plurality of ultrasound transducers, and a low frequency vibrator arranged to induce a displacement of said single ultrasound transducer or plurality of ultrasound transducers towards a tissue. The device is configured to emit a sequence of ultrasound pulses and to acquire echo signals received in response to track how elastic waves, induced by the displacement, travel in the tissue. The device is configured to generate, for one or more of the ultrasound pulses emitted a temporal offset upon emission, and/or a temporal offset upon reception, so that a difference thereof varies as a function of 2·d/vus, where d is the displacement of the single transducer or plurality of ultrasound transducers, and where vus is the speed of ultrasound in said tissue.

Abstract: A system and method for accumulating ultrasound attenuation data for the detection of disease or other conditions. In one embodiment, an ultrasound system generates a number of imaging pulses during an imaging mode. Echo signals received from the imaging pulses are tested against one or more quality metrics. Attenuation data from the echo signals that pass the quality metrics are accumulated and are used to compute a tissue characteristic. In one embodiment the tissue characteristic is a CAP measurement that is related to an amount of fat in a liver.

Abstract: A method for measuring an ultrasonic attenuation parameter guided by harmonic elastography including applying, using a vibrator included in a probe in contact with a viscoelastic medium, of a continuous low frequency vibration, the continuous low frequency vibration generating an elastic wave within the viscoelastic medium and generating, during the propagation of the elastic wave, using an ultrasonic transducer in contact with the viscoelastic medium, a series of ultrasonic acquisitions, the series of ultrasonic acquisitions including groups of ultrasonic acquisitions, the groups of ultrasonic acquisitions being generated with a repetition rate, each group of ultrasonic acquisitions including at least one acquisition; the ultrasonic attenuation parameter being measured from the ultrasonic acquisitions realised during the application of the continuous low frequency vibration.

Abstract: A transient elastography probe includes a probe body; an ultrasound transducer configured to generate an ultrasound beam along an axis, the ultrasound beam being generated from a face of the ultrasound transducer; a vibrator located inside the probe body and arranged so as to induce a movement of the ultrasound transducer along a predefined axis; the ultrasound transducer being mounted on the vibrator so that the predefined axis and the axis of the ultrasound beam coincide with each other, and a sealing membrane hugging the outer contours of the ultrasound transducer.

Abstract: A method for measuring viscoelastic properties of a viscoelastic medium, the method including positioning a probe in contact with the viscoelastic medium, the probe extending along a longitudinal axis and being adapted to carry out transient elastography measurements and including a casing, at least one ultrasound a transducer arranged at a tip of the probe and adapted to generate ultrasounds, a force sensor configured to measure a force applied by the tip of the probe, and a vibrator arranged in the casing and adapted to generate a low-frequency wave, measuring a contact force by the force sensor; generating a measurement ready signal by the probe when the measured contact force is higher than a minimum measurement force threshold, and when the measurement ready signal has been generated, triggering a transient elastography measurement.

Abstract: A device for vibration controlled transient elastography, in particular to quantify liver fibrosis, includes an ultrasound probe for elastography comprising a probe casing, at least one ultrasound transducer having a symmetry axis, a vibrator, and a force sensor, wherein the vibrator is arranged to induce a movement of the probe casing along the symmetry axis of the ultrasound transducer, the ultrasound transducer being bound to the probe casing with no motion of the ultrasound transducer relative to the probe casing, and wherein the device includes a signal generator configured to issue a contact ready signal when the force applied by the probe on the to-be-measured viscoelastic medium is greater than a minimum contact force threshold. The signal generator may further be configured to issue a measurement ready signal when the force is greater than a minimum measurement force threshold.

Abstract: A system for characterizing tissue includes a probe that delivers a continuous and periodic mechanical vibration to a tissue of a subject; an ultrasound emitter that emits a sequence of ultrasound shots and an ultrasound receiver that receives corresponding echo signals to track how the tissue is moved by the periodic mechanical vibration delivered to the tissue; and a control module programmed to provide homogeneity information to an operator of the system, the homogeneity information being determined from at least some of the echo signals and being representative of the ability of the tissue to transmit elastic waves and of the homogeneity of the tissue with respect to the propagation of elastic waves.

Abstract: A multipulse elastography method for the quantitative measurement of at least one mechanical property of a viscoelastic medium having an ultrasonic signal after ultrasonic illumination, the method including defining characteristics of at least two mechanical pulses; generating the at least two mechanical pulses for which characteristics are defined in a viscoelastic medium; monitoring a propagation of at least two shear waves generated by the at least two mechanical pulses using acquisition and emission of ultrasonic signals, in the viscoelastic medium, and calculating at least one mechanical property of said viscoelastic medium using said acquisitions of said ultrasonic signals.

Abstract: A method for automatically selecting a calculation depth range upon measuring a property of a viscoelastic medium, the depth range being selected from P possible ranges, includes calculating, from the ultrasound signal acquired using a probe for elastography, the property of the viscoelastic medium in at least one of the P depth ranges as well as the distance between the probe and the wall of the viscoelastic medium; determining the validity of at least one of the P calculation depth ranges; determining the validity of the calculation of the property of the viscoelastic medium over the valid calculation depth range or ranges; selecting, from the values of the property of the viscoelastic medium the calculation of which is valid at the valid depth ranges, a depth range fulfilling a selection criterion.

Abstract: A method for measuring a viscoelastic parameter of an organ, includes emitting ultrasonic shots by an ultrasonic transducer; receiving by the transducer and recording the reflected ultrasonic signals; determining a viscoelastic parameter of the organ based on the recorded ultrasonic signals. The ultrasonic shots are formed by K groups of shots, separated temporally, K being greater than or equal to 1. Each K group is formed by the repetition, with a rate of PRF2, of MK blocks of ultrasonic shots, MK being greater than or equal to 1; each MK block is composed of N ultrasonic shots, N being greater than or equal to 1, PRF1 being the rate of emission of the N shots when N is chosen greater than 1; the N ultrasonic shots are distributed over P frequencies, P being between 1 and N, at least two ultrasonic shots belonging to two different blocks having different frequencies.

Abstract: A hybrid elastography method includes application of a continuous low frequency vibration and generation, using an ultrasonic transducer in contact with the viscoelastic medium, of a first series of ultrasonic acquisitions, the first series of ultrasonic acquisitions including groups of ultrasonic acquisitions, the groups of ultrasonic acquisitions being generated with a first repetition rate, each group of ultrasonic acquisitions including at least one acquisition, the continuous vibration generating an elastic wave within the viscoelastic medium; application of a low frequency pulse and generation, using the ultrasonic transducer, of a second series of ultrasonic acquisitions, the ultrasonic acquisitions composing the second series being generated with a second repetition rate, the low frequency pulse generating a transient shear wave propagating within the viscoelastic medium; the continuous vibration applied by the first vibrator being stopped before the application of the low frequency pulse.

Abstract: A device for vibration controlled transient elastography, in particular to quantify liver fibrosis, includes an ultrasound probe for elastography comprising a probe casing, at least one ultrasound transducer having a symmetry axis, a vibrator, and a force sensor, wherein the vibrator is arranged to induce a movement of the probe casing along the symmetry axis of the ultrasound transducer, the ultrasound transducer being bound to the probe casing with no motion of the ultrasound transducer relative to the probe casing, and wherein the device includes a signal generator configured to issue a contact ready signal when the force applied by the probe on the to-be-measured viscoelastic medium is greater than a minimum contact force threshold. The signal generator may further be configured to issue a measurement ready signal when the force is greater than a minimum measurement force threshold.

Abstract: A probe for transient elastography includes a probe casing, at least one ultrasound transducer having a symmetry axis, a vibrator located inside the probe casing, a position sensor coupled to the probe casing, the position sensor being arranged to measure the displacement of the probe, wherein the vibrator is arranged to induce a movement of the probe casing along a predefined axis, the predefined axis being the symmetry axis of the ultrasound transducer. The ultrasound transducer is bound to the probe casing with no motion of the ultrasound transducer with respect to the probe casing, and the probe includes a feedback circuit including the position sensor and a control loop and configured to use the displacement of the probe as a feedback signal and to control the movement of the vibrator inside the probe casing and the shape of a low frequency pulse applied by the probe.

Abstract: An interchangeable tip for ultrasound probe housing includes: at least one ultrasound transducer constructed and configured to emit and receive ultrasound signals, at least one electrical contact of tip, each electrical contact of tip being constructed and configured to cooperate with an electrical connector, a tip connector constructed and configured to secure the interchangeable tip with an ultrasound probe housing.

Abstract: A device calculates a score reflecting a state of liver damage, the calculating device being designed to calculate a score using the following physical parameters: a parameter corresponding to inflammation and/or fibrosis; and a parameter corresponding to steatosis.

Abstract: A non-invasive system for calculating a human or animal score, the system including a measurement slave device constructed and arranged to carry out measurements of biological parameters; a measure slave device constructed and arranged to carry out measurements of physical parameters; a master device constructed and arranged to collect the biological and physical parameters and calculate the human or animal score, the score including biological and physical parameters.

Abstract: A method for measuring at least one property of biological tissue, including: positioning an ultrasonic transducer opposite the biological tissue to be measured; generating an ultrasonic signal within the biological tissue; acquiring at least one ultrasonic signal reflected by the biological tissue; determining at least one parameter of the biological tissue using the acquisition of the ultrasonic signal reflected by the biological tissue, the at least one parameter being representative of the biological tissue; comparing the at least one parameter of the biological tissue with at least one reference parameter of a target biological tissue so as to confirm the hypothesis of the presence of the target biological tissue opposite the ultrasonic transducer; and determining at least one property of the biological tissue on the basis of the result of the comparison. The method can be directly used in the field of humans or animals.

Abstract: A method for determining, in real time, the probability that target biological tissue is opposite an ultrasonic transducer, the method including: transmitting, via an ultrasonic transducer, an ultrasonic signal into biological tissue; the ultrasonic transducer receiving the transmitted ultrasonic signal which has been backscattered by the biological tissue; calculating at least two instantaneous parameters of the backscattered ultrasonic signal; calculating a predictive value of the presence of an acoustic signature of target biological tissue, the predictive value being calculated via a statistical law using the at least two calculated instantaneous parameters; estimating the probability that the target biological tissue is opposite the ultrasonic transducer, the estimation depending on the calculated predictive value and/or on at least one strength condition based on at least one of the two calculated instantaneous parameters.