Patents Assigned to Ecole Polytechnique Fédérale de Lausanne
-
Patent number: 11961300Abstract: A method of classifying a media includes receiving a media file and extracting therefrom first and second data streams including first and second media content, respectively, the media content being associated with the media item. First and second feature vectors describing the first and second media content, respectively, are generated. At least a first single feature vector representing the first sequence of first feature vectors and the second sequence of second feature vectors is generated, or at least a first single feature vector representing at least the first sequence of first feature vectors is generated. A second feature vector representing at least the second sequence of second feature vectors is generated. A probability vector from the first single feature vector, or from the first and second single feature vectors is generated. A user profile suitability class is assigned to the media item based on the probability vector.Type: GrantFiled: April 29, 2019Date of Patent: April 16, 2024Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Gabriel Autès, Sami Arpa, Sabine Süsstrunk
-
Publication number: 20240115863Abstract: A system for measuring synchrony between two or more regions, or within a single region, of a subject's brain. The system can include a signal conditioning module in communication with a phase extraction module. The signal conditioning module can receive an oscillating signal, bandpass filter the signal, and convert the signal to its real and imaginary components. The phase extraction module can receive the real and imaginary components, determine the quadrant of the oscillating signal on the complex plane based on the real and imaginary components, and determine the phase of the oscillating signal using a linear arctangent approximation based on the determined quadrant. The system can calculate synchrony metrics based on the determined phase.Type: ApplicationFiled: January 26, 2022Publication date: April 11, 2024Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA, ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL), CORNELL UNIVERSITYInventors: Alik WIDGE, Mahsa SHOARAN, Uisub SHIN
-
Publication number: 20240108252Abstract: A micromachined mechanism for a sensing tool includes a support, a probe pivotally mounted with respect to the support, and a beam connected to the support and the probe. The probe is configured to apply a load (Ftool) on a body and to be subjected to a counter-reaction contact force exerted by the body in reaction to the load. The beam is configured to shift from an undeformed position to a deformed position when the contact force of the body is greater than a predetermined threshold force (Fcrit) for which the beam buckles.Type: ApplicationFiled: December 4, 2023Publication date: April 4, 2024Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNEInventors: Loic Tissot-Daguette, Charles Baur, Hubert Schneegans, Axel Bertholds, Pere Llosas
-
Publication number: 20240100337Abstract: A method for controlling connectivity between two or more brain regions of a subject includes receiving signals corresponding to a connectivity between two or more regions of a subject's brain, measuring a connectivity level from the signals, and delivering at least one stimulation pulse to at least one target region of the subject's brain if the measured connectivity level is outside of a predetermined range.Type: ApplicationFiled: January 26, 2022Publication date: March 28, 2024Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA, ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL), CORNELL UNIVERSITYInventors: Alik WIDGE, Gregory MOLNAR, Virginia WOODS, Mahsa SHOARAN, Uisub SHIN
-
Publication number: 20240091063Abstract: An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.Type: ApplicationFiled: July 26, 2023Publication date: March 21, 2024Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Stephane BIGLER, Nikolaos STERGIOPULOS
-
Patent number: 11911621Abstract: The present disclosure provides devices, systems, and methods for spinal cord stimulation. In some exemplary embodiments, a lead is provided. In one exemplary embodiment, the lead includes a paddle and an electrode array distributed in the paddle. The electrode array includes a first column of electrodes and a second column of electrodes. The first column of electrodes and the second column of electrodes are symmetric about the midline of the paddle. The first column of electrodes includes a first electrode, a second electrode, and a third electrode. The second column of electrodes includes a fourth electrode corresponding to the first electrode, a fifth electrode corresponding to the second electrode, and a sixth electrode corresponding to the third electrode. A vertical inter-electrode distance between the first electrode and the second electrode is larger than that between the second electrode and the third electrode.Type: GrantFiled: June 24, 2021Date of Patent: February 27, 2024Assignees: ONWARD MEDICAL N.V., ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNEInventors: Damien Ganty, Edoardo Paoles, Jocelyne Bloch, Gregoire Courtine, Leonie Asboth, Robin Demesmaeker, Henri Lorach, Jordan Squair, Tomislav Milekovic, Andreas Rowald
-
Patent number: 11911107Abstract: A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable and arranged to direct light towards at least one of a retina and an iris of the eye, causing an output beam from light backscattered from the at least one of the retina and the iris by the oblique illumination, capturing the output beam with an imaging system to provide a sequence of images of a fundus of the eye, and retrieving a phase and absorption contrast image from the sequence of images of the fundus, wherein the sequence of images of the fundus of the step of capturing is obtained by sequentially turning on one or more of the plurality of light emitting areas at a time in the step of providing the oblique illumination.Type: GrantFiled: October 29, 2021Date of Patent: February 27, 2024Assignee: ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)Inventors: Timothé Laforest, Dino Carpentras, Christophe Moser, Mathieu Künzi, Francine Behar-Cohen
-
Patent number: 11900237Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for organizing trained and untrained neural networks. In one aspect, a neural network device includes a collection of node assemblies interconnected by between-assembly links, each node assembly itself comprising a network of nodes interconnected by a plurality of within-assembly links, wherein each of the between-assembly links and the within-assembly links have an associated weight, each weight embodying a strength of connection between the nodes joined by the associated link, the nodes within each assembly being more likely to be connected to other nodes within that assembly than to be connected to nodes within others of the node assemblies.Type: GrantFiled: September 20, 2021Date of Patent: February 13, 2024Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Henry Markram, Rodrigo de Campos Perin, Thomas K. Berger
-
Patent number: 11884854Abstract: The present invention relates to a method for producing core-shell nanocrystals consisting of a metal-containing nanocrystal core and a shell layer comprising at least one metal oxide material having variable shell thicknesses, and use of the core-shell nanocrystals for different applications.Type: GrantFiled: March 27, 2020Date of Patent: January 30, 2024Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Anna Loiudice, Raffaella Buonsanti
-
Patent number: 11884721Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired. Fusions with targeting peptides direct the fusions to the target, for instance a tumor, where the erythrocyte-binding ligands reduce or entirely eliminate blood flow to the tumor by recruiting erythrocytes to the target.Type: GrantFiled: January 7, 2021Date of Patent: January 30, 2024Assignee: École Polytechnique Fédérale de Lausanne (EPFL)Inventors: Jeffrey A. Hubbell, Stephan Kontos, Karen Y. Dane
-
Patent number: 11879227Abstract: The present invention relates to a method for inducing ground consolidation. The method comprises providing a first chamber in a first hole in the ground, and a second chamber in a second hole in the ground, the first and second chambers being liquid-impermeable and electrically conductive; providing a first electrolytic fluid in the first chamber and a second electrolytic fluid in the second chamber; placing at least a first electrode in the first chamber, and at least a second electrode in the second chamber, the first and second electrodes being operatively connected to a power supply; feeding consolidation fluids into the ground for feeding reactants of a consolidation process, and catalysers for the reactants into the ground; and applying to the first and second electrodes an electric current.Type: GrantFiled: May 31, 2019Date of Patent: January 23, 2024Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Dimitrios Terzis, Lyesse Laloui, Patrick Hicher
-
Patent number: 11872559Abstract: The present invention concerns a microfluidic device or chip including at least one inlet for introducing at least one object into the device; an oil inlet for introducing an oil that supports droplet formation into the device or a droplet forming substance inlet for introducing a droplet forming substance into the device; a co-encapsulation area or structure where the at least one object is encapsulated by the droplet; a microfluidic tubing or channel for transporting the at least one object to an entrance of the co-encapsulation area or structure; an oil supporting droplet formation microchannel or droplet forming substance microchannel connected to the microfluidic tubing or channel to place a liquid of the microfluidic tubing or channel in direct contact with the oil that supports droplet formation or the droplet forming substance; and a droplet microchannel or tubing for transporting the droplet.Type: GrantFiled: September 13, 2017Date of Patent: January 16, 2024Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Bart Deplancke, Johannes Bues, Riccardo Dainese, Marjan Biocanin
-
Patent number: 11872746Abstract: Photoresponsive materials for use with a volumetric additive manufacturing system are described herein. Some embodiments of photoresponsive materials described herein include at least one constituent selected from the group consisting of (i) a thiol-containing siloxane prepolymer, (ii) a vinyl-containing siloxane prepolymer, (iii) a reinforcing filler, (iv) a photoinitiator (v) a polymerization inhibitor. Various methods of using the same photoresponsive materials in additive manufacturing processes, such as volumetric additive manufacturing, are also described.Type: GrantFiled: November 5, 2019Date of Patent: January 16, 2024Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Paul Delrot, Damien Loterie, Christophe Moser
-
Patent number: 11872290Abstract: The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of said first silencer sequence within astrocytes is regulated by an astrocyte-specific promoter and the expression of said second silencer sequence within neurons is regulated by a neuron-specific promoter. In a preferred embodiment, said first and second silencer sequences are SOD1 silencer sequences. Pharmaceutical composition comprising said bicistronic vector and the use of the same in the treatment of motoneuron diseases are further described.Type: GrantFiled: October 26, 2020Date of Patent: January 16, 2024Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Julianne Aebischer, Bernard Schneider, Cylia Rochat
-
Patent number: 11864877Abstract: The invention relates to a photoplethysmography (PPG) sensing device comprising—a pulsed light source, —at least one pixel to create photo-generated electrons, synchronized with said pulsed light source. It is mainly characterized in that each pixel comprises: —a pinned photodiode (PPD) having two electronic connection nodes, —a sense node (SN), to convert the photo-generated electrons into a voltage, and—a Transfer Gate (TGtransfer) transistor, having its source electronically connected to one electronic connection node of said pinned photodiode (PPD), and being configured to act as a transfer gate (TG) between said pinned photodiode (PPD) and said sense node (SN), allowing the photo-generated electrons to sink when the light is pulsed-off, the photo-generated electrons integration when the light is pulsed-on and the transfer of at least part of the integrated photo-generated electrons to said sense node for a read-out.Type: GrantFiled: January 4, 2023Date of Patent: January 9, 2024Assignee: ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)Inventors: Assim Boukhayma, Antonino Caizzone, Christian Enz
-
Patent number: 11857945Abstract: Disclosed is the use of a composite for extracting one or more metal or contaminating chemical species from an aerial or aqueous medium by selective binding, the composite including at least one porous template functionalized by at least one polymer, the polymer including one of the following chemical functions: primary, secondary or tertiary amine, amide, nitrile, pyridine, pyrole, thiol, thiolether, thiophene, thiadiazole, alcohol/hydroxyl, phenol, catechol, pyragalol, carboxylic acid, aldehyde, ester, acyl, crown ether, phosphate, phosphoryl, epoxide, halogen, haloalkane.Type: GrantFiled: January 18, 2022Date of Patent: January 2, 2024Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Wendy Lee Queen, Daniel Teav Sun
-
Patent number: 11856861Abstract: A spring (3, 3?) comprising a plurality of elements (30), each element (3) comprising a rigid portion (31) and a flexible beam (32), the extremities (320, 321) of the flexible beam being supported by the rigid portion (31), the flexible beam (32) having a single stable position, so that the flexible beam can be deformed when a pressure is exerted between said extremities in the direction of the rigid portion (31), and returns to said single stable position when the pressure is released, and wherein the rigid portion (31) of at least one element (30) is in contact with the flexible beam (32) of the next element between said extremities (320, 321) of the flexible beam (32), so that the spring has a negative stiffness over an operating range. The arrangement ensures a pure radial compression/expansion of the spring.Type: GrantFiled: November 23, 2018Date of Patent: December 26, 2023Assignee: Ecole Polytechnique Federale De LausanneInventors: Jonathan Chavanne, Yoan Civet, Yves Perriard
-
Patent number: 11845779Abstract: Aerolysin polypeptides and/or mutant aerolysin monomers include modified amino acid sequences that could have improved substrate analyte, such as (poly)nucleotide and peptide, improved reading properties such as enhanced substrate analyte capture and improved substrate analyte recognition and/or discrimination. Also, aerolysin pores may be derived from the mutant monomers as well as apparatuses and devices may include modified aerolysin polypeptides. Further, methods of using modified aerolysin proteins and pores derive therefrom may be used in characterizing and/or sequencing a polymeric molecule or may be for use as molecular sensors.Type: GrantFiled: October 28, 2020Date of Patent: December 19, 2023Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Matteo Dal Peraro, Chan Cao
-
Patent number: 11846608Abstract: The present invention concerns an array processing image reconstruction method comprising: receiving a set of echo waveforms as measurements from the object of interest; defining a measurement model linking an unknown image of the object to the measurements; defining a data fidelity functional using the measurement model; defining a regularisation functional using a trained non-linear mapping, the regularisation functional comprising prior knowledge about the unknown image; defining an optimisation problem involving the data fidelity functional and the regularisation functional for obtaining a first image estimate of the unknown image; and solving the optimisation problem to obtain the first image estimate.Type: GrantFiled: August 29, 2019Date of Patent: December 19, 2023Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Dimitris Perdios, Adrien Besson, Florian Martinez, Marcel Arditi, Jean-Philippe Thiran
-
Patent number: 11831366Abstract: Using a transformation based at least in part on a non-simple orthogonal or unitary matrix, data may be transmitted over a data bus in a manner that is resilient to one or more types of signal noise, that does not require a common reference at the transmission and acquisition points, and/or that has a pin-efficiency that is greater than 50% and may approach that of single-ended signaling. Such transformations may be implemented in hardware in an efficient manner. Hybrid transformers that apply such transformations to selected subsets of signals to be transmitted may be used to adapt to various signal set sizes and/or transmission environment properties including noise and physical space requirements of given transmission environments.Type: GrantFiled: March 21, 2023Date of Patent: November 28, 2023Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNEInventors: Harm Cronie, Amin Shokrollahi