Abstract: The present invention concerns a method for encoding a given 3D shape into a target 2D linkage. The method comprises: (a) providing an initial 2D surface; and (b) defining on the initial 2D surface an auxetic pattern of geometric elements planarly linked between them to obtain the target 2D linkage, the pattern allowing the target 2D linkage to be virtually stretched. The target 2D linkage has a spatially varying scale factor thereby spatially varying the stretching capability of the 2D linkage.

Abstract: Molecular sensing system including: a sensing device (5) comprising at least one support layer (10), and an active layer (6) mounted on said support layer and having at least one nano-pore (12) configured for translocation of a molecular analyte (18) therethrough; an electrically conducting liquid (4) in contact with the active layer in a region around said nano-pore; and a signal processing circuit (7) comprising an ionic current circuit (8) configured to generate and measure an ionic current (Ii) in the electrically conducting liquid influenced by the translocation of the molecular analyte through the nano-pore. The molecular sensing device of the invention allows for single-nucleotide discrimination and detection of the specific sequence within ssDNA.

Abstract: A signal processing apparatus, being configured for transmitting and receiving coherent parallel optical signals, comprises a transmitter apparatus including a first single soliton micro-resonator device and a modulator device, wherein the first single soliton micro-resonator device is adapted for creating a single soliton providing a first frequency comb, wherein the first frequency comb provides a plurality of equidistant optical carriers with a frequency spacing corresponding to a free spectral range of the first single soliton micro-resonator device, and the modulator device is adapted for modulating the optical carriers according to data to be transmitted, and a receiver apparatus including a coherent receiver device with a plurality of coherent receivers and a local oscillator device providing a plurality of reference optical signals, wherein the coherent receiver device and the local oscillator device are arranged for coherently detecting the transmitted modulated optical carriers, wherein the signal p

Abstract: An oscillator arrangement for time-to-digital converters for a 3D image sensor device includes a plurality of oscillators arranged as an array each oscillator being associated to one time-to-digital converter, and at least one coupling unit respectively arranged between at least two of the oscillators, so that oscillation in the at least two oscillators at a fundamental frequency is synchronized between the at least two coupled oscillators.

Abstract: The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.

Abstract: The present invention concerns a method for generating technical design solutions satisfying a given performance target for a building. The method comprises: selecting a design model for the building; selecting a first set of design parameters from a first database; qualifying and/or quantifying the design parameters in the first set; generating a first set of design parameter combinations from the first set of design parameters; attributing the first set of design parameter combinations to the design model to obtain a first set of design alternatives; accessing a second database to determine the impact of the first set of design alternatives on a performance of the building; and ranking the first set of design parameters according to their contribution to the performance of the building.

Abstract: The invention relates to the selective targeting of specific ?2 adrenergic receptor subtypes for facilitating and also restoring standing and walking in a subject affected by spinal cord disorders, in particular spinal cord injury. In particular, the improvement of locomotion by targeting specific receptor subtypes can be achieved by stimulation of the ?2c receptor subtype using an ?2c specific agonist or by blocking the ?2a receptor subtype using ?2a antagonists. A combination of an ?2c agonist and an ?2a antagonist is also provided for a synergistic effect. Alternatively, a large ?2 agonist can be used in combination with an ?2a antagonist to achieve specific stimulation of the ?2c receptor. Pharmaceutical compositions, kit-of-parts and therapeutic systems comprising said agonists/antagonists as active agents are objects of the present invention.

Abstract: A functional optical coherent imaging (fOCI) platform includes at least one active camera unit (ACU) having a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD.

Abstract: An add-on device for use in combination with a stereotactic apparatus is herein disclosed, the device including a stereotactic adapter, an optical support comprising lenses and a display support adapted to accommodate a virtual reality display. The stereotactic adapter can adapt to different commercial models of stereotactic systems, and is particularly intended for implementing a method for conducting cognitive and/or behavioral tests in subjects during neurosurgery, wherein a virtual reality stimulus is provided to said subject during awake phases of neurosurgery.

Abstract: A mechanical teleoperated device for remote manipulation includes a slave unit having a number of slave links interconnected by a plurality of slave joints; an end-effector connected to the slave unit; a master unit having a corresponding number of master links interconnected by a plurality of master joints; and a handle connected to a distal end of the master unit. The device further includes first device arranged to kinematically connect the slave unit with the master unit, second device arranged to kinematically connect the end-effector with the handle, and a mechanical constraint device configured to ensure that one master link of the master unit is guided along its longitudinal axis so that the corresponding slave link of the slave unit always translates along a virtual axis parallel to the longitudinal axis of the guided master link in the vicinity of the remote manipulation when the mechanical teleoperated device is operated.

Abstract: An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.

Abstract: Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device operates on the principles of a Starling resistor, and includes a housing, a deformable structure and a spring mounted within a housing, such that the spring applies a substantially constant spring force over a predetermined working range on the deformable structure to thereby self-regulate flow of fluid through the deformable structure.

Abstract: The invention relates to devices, systems and methods exploiting capacitive means for monitoring and analysing teeth-related parameters in a subject, such as the dental occlusion profile and/or the load/force applied upon clenching. The device comprises a body such as a bite fork or bite splint, capacitive sensor(s) incorporated within a soft substrate reversibly deformable once bitten by a subject and a micro-controller unit. The teeth contact points and forces applied upon occlusion are measured via the sensors, delivered to and re-elaborated by the micro-controller unit and possibly sent and visualized in a graphical/numerical fashion on e.g. a display screen.

Abstract: A method for manufacturing an object including the steps of forming layers by adding successive layers of material to form the object by selective laser melting (SLM), and inducing plastic deformation and residual stress into solidified material of at least one of the successive layers of material to improve mechanical properties and a fatigue resistance of the object, wherein the plastic deformation and the residual stress are induced by a laser.

Abstract: A mechanical isotropic harmonic oscillator including a two rotational degrees of freedom linkage supporting an orbiting mass with respect to a fixed base with at least one spring element having isotropic and linear restoring force properties, such that a high degree of spring stiffness and reduced mass isotropy provides for reduced sensitivity to linear and angular accelerations.

Abstract: The present invention relates to a solar cell comprising a heterojunction photoelectric device comprising, a front electrode layer, a back electrode layer comprising a metallic contact layer, a light-absorbing silicon layer arranged between said front electrode and said back electrode layers and a doped silicon-based layer arranged between said light-absorbing silicon layer and said back electrode layer, characterized in that said heterojunction photoelectric device further comprises a wide band gap material layer having an electronic band gap greater than 1.4 eV, said wide band gap material layer being applied on a surface of the light-absorbing silicon layer between said light-absorbing silicon layer and said doped silicon-based layer. The present heterojunction layer or stack of layers is compatible with thermal annealing and firing processes at T above 600° C.

Abstract: Data storage and retrieval systems, methods, and computer-readable media utilize a cryptographically verifiable data structure that facilitates verification of a transaction in a decentralized peer-to-peer environment using multi-hop backwards and forwards links. Backward links are cryptographic hashes of past records. Forward links are cryptographic signatures of future records that are added retroactively to records once the target block has been appended to the data structure.

Abstract: The invention relates to titanium oxide aerogels, in particular to titanium oxide binary or ternary (e.g. titanium oxide-carbon) aerogel monoliths possessing ordered meso- and macroporosity. The porous scaffold can be made with or without addition of binders and/or surfactants. The aerogel obtained by this method has a specific surface area greater than 60 m2/g and porosity larger than 60%. The surface area ranges from 60 to 300 m2/g. The porosity can reach as high as 99.6%. The size of the titanium oxide crystals are between 5 nm and 100 nm. The aerogel contains 100% titanium oxide. The composite (binary or ternary) aerogel can be prepared by adding at least 10% carbon in the form of (carbon nanotubes, carbon nanofibers, carbon microfibers, exfoliated graphene, cellulose fibers, polymer fibers, metallic and metal oxide nano and microfibers etc.). The aerogel can be prepared with a predeterminable shape. It can be shaped in a mold having a shape of a cylinder, cube, sheet or sphere.

Abstract: A method for training a feature detector of an image processing device, including the steps of detecting features in the image to generate a score map, computing a center of mass on the score map to generate a location, extracting a patch from the image at the location by a first spatial transformer, estimating an orientation of the patch, rotating the patch in accordance with the patch orientation with a second spatial transformer, and describing the rotated patch to create a description vector.

Abstract: A method of analyzing molecules, comprising: generating ions from a sample of molecules; cooling the generated ions below ambient temperature; fragmenting at least some of the cooled ions by irradiating the ions with light at a plurality of different wavelengths (?) within one or more predetermined spectral intervals; recording a fragment mass spectrum of the fragmented ions comprising a detected signal (I) versus m/z over a predetermined range of m/z values for each of the plurality of different wavelengths (?), thereby recording a two-dimensional dependency of the detected signal (I) on m/z and irradiation wavelength (?); and determining from the recorded two-dimensional dependency an identity of at least one of the generated ions and/or relative abundances of different generated ions and thereby determining an identity of at least of one of the molecules and/or relative abundances of different molecules in the sample.