Abstract: The present invention relates to a method for preparing monomers via depolymerisation from lignocellulose-containing biomass.

Abstract: A dual-frequency-comb spectrometer and a method for spectroscopic investigation of a sample are described. The spectrometer includes first and second frequency comb devices for emitting laser pulses along first and second light paths, wherein the repetition frequency of the laser pulses emitted by the second device is offset from that of the first device. First and second multi-core waveguides including at least two separate single core waveguides having field-coupling via a coupling gap therebetween are arranged in the first and second light paths. The sample is irradiated by the second frequency comb in the second light path. A detector device is arranged in a third light path where the first and second light paths are combined, for simultaneously sensing the first frequency comb and the second frequency comb after an interaction with the sample. A computing device receives output of the detector device and calculates spectroscopic properties of the sample.

Abstract: A polymer-based optoelectronic interface comprises an elastomeric substrate (10) and a plurality of discrete photovoltaic pixel elements (20) disposed on top of the substrate. Each pixel element comprises at least one active layer comprising a semiconducting polymer or polymer mixture. The pixel elements are excitable by light to generate an electric signal via a photovoltaic process. For mechanically protecting the pixel elements, an elastomeric encapsulation layer (30) can be disposed on top of the substrate, the encapsulation layer defining access openings (31) for the pixel elements (20). Pillar-like structures (40) can be disposed on the pixel elements. Methods for fabricating such an optoelectronic interface are also disclosed. The optoelectronic interface can be used as a retinal prosthesis.

Abstract: Several embodiments of the present disclosure relate to therapeutic compositions configured to target the liver of a subject and that are useful in the treatment or prevention of one or more of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. In several embodiments, the compositions are configured for clearance of a circulating protein or peptide or antibody associated with one or more of the above-mentioned maladies. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.

Abstract: The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.

Abstract: A system for adjusting pressure locally acting on the skin including a set of adjacent modules distributed so as to form a layer each module includes a cushion capable of changing shape and comprising a cavity, a valve, a tank, and a pressure sensor, wherein the cavity and the tank are in communication with each other by means of the valve, and the sensor is placed so as to sense pressure directly or indirectly acting on the cushion and a feedback loop arranged such as to increase or decrease the change in the shape of the cushion on the basis of the pressure detected by the sensor.

Abstract: Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.

Abstract: The present relates to a carbon material having a 3D structure and made of graphene oxide and carbon nanotubes, characterized in that the 3D structure consists in that the carbon nanotubes are located with some agglomeration between the graphene oxide layers so as to extend the spacing between the graphene oxide layers

Abstract: The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of said first silencer sequence within astrocytes is regulated by an astrocyte-specific promoter and the expression of said second silencer sequence within neurons is regulated by a neuron-specific promoter. In a preferred embodiment, said first and second silencer sequences are SOD1 silencer sequences. Pharmaceutical composition comprising said bicistronic vector and the use of the same in the treatment of motoneuron diseases are further described.

Abstract: A distributed memory system including a plurality of chips, a plurality of nodes that are distributed across the plurality of chips such that each node is comprised within a chip, each node includes a dedicated local memory and a processor core, and each local memory is configured to be accessible over network communication, a network interface for each node, the network interface configured such that a corresponding network interface of each node is integrated in a coherence domain of the chip of the corresponding node, wherein each of the network interfaces are configured to support a one-sided operation, the network interface directly reading or writing in the dedicated local memory of the corresponding node without involving a processor core, and the one-sided operation is configured such that the processor core of a corresponding node uses a protocol to directly inject a remote memory access for read or write request to the network interface of the node, the remote memory access request allowing to read

Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired. Fusions with targeting peptides direct the fusions to the target, for instance a tumor, where the erythrocyte-binding ligands reduce or entirely eliminate blood flow to the tumor by recruiting erythrocytes to the target.

Abstract: The present invention concerns a multiple soliton comb generation method comprising the steps of: providing a single optical resonator configured to support a plurality of distinct spatial modes in which light can propagate; providing an optical pump laser source; simultaneously optically pumping a plurality of distinct spatial modes of the single optical resonator to simultaneously generate independent soliton states in the distinct spatial modes and generate a plurality of frequency combs.

Abstract: The present invention relates to agents that induce mitochondrial unfolded protein response (UPR mt) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of muscle stem senescence.

Abstract: The present invention relates to a method for preparing monomers via depolymerisation from lignocellulose-containing biomass.

Abstract: A connector for providing both a fluidic and electrical connection is disclosed, said connector having a proximal end, a distal end and an elongated body in between, characterized in that the elongated body has an inner cavity spanning throughout its length, and the distal end comprises: a) an inner body portion comprising a first inner electrical contact and b) an outer body portion comprising a second outer electrical contact having a spring element. The connector is easily adaptable to many kind of fluidic actuators and particularly to pipette instruments usually found in laboratory practice and developed to adapt fluidic actuators and pipette instalments to work according to the Coulter principle in every working condition, in particular to adapt the electrical and fluidic connection between a sensing tip and an instrumented pipette.

Abstract: A retinal projector system, comprising a coupling means, a spacial light modulator, and a tapered optical waveguide having an input side surface and an output side surface, whereby the input side surface is larger than the output side surface, the coupling means being configured to couple coherent light into the spatial light modulator, the spacial light modulator being configured to receive the coherent light and output modulated light modulated in 2 dimensions towards the input side surface, the tapered optical waveguide being configured to guide the modulated light received at the input side surface and reduce a size of the tapered optical waveguide towards the output side surface, without losing any information from the modulated light at the output side surface such to allow an image formation.

Abstract: The present invention concerns a membrane-less electrolyzer comprising a fluidic channel for receiving an electrolyte fluid; a first electrode and a second electrode located inside the fluidic channel, the first and second electrode permitting to extract a first gas and a second gas inside the fluidic channel from the electrolyte fluid, the first electrode and second electrode being separated by solely a surrounding fluid in the fluidic channel or the electrolyte; and a first fluidic transport channel for transporting the first gas to a first outlet and a second fluidic transport channel for transporting the second gas to a second outlet.

Abstract: Disclosed are methods of synthesis of an oxidized nickel foam electrode incorporating iron including the step of subjecting a nickel foam electrode to repetitive cyclic voltammetric scans in a basic solution containing iron. Also disclosed is an oxidized nickel foam electrode the oxidized nickel foam incorporating iron, and use of such an electrode as a catalyst for oxygen evolution reaction. Also disclosed is a water splitting device such as an electrolyzer including such an electrode.

Abstract: The present invention describes methods and apparatuses for creating superposition shape images by superposed base and revealing layers of lenslet gratings. The superposition shape images form a message recognizable by a human observer or by an image acquisition and computing device such as a smartphone. The superposition shape images may be created by different superposition techniques ranging from 1D moiré, 2D moiré and level-line moiré superposition techniques to lenticular image and phase shift superposition techniques. Moiré superposition techniques enable creating superposition shape images at different apparent depth levels. Applications comprise the protection of documents and valuable articles against counterfeits, the creation of eye-catching advertisements as well as the decoration of buildings and exhibitions.

Abstract: Ionic polymers (IP) are made of anions and a polymeric backbone containing cations. The ionic polymers are incorporated in membranes or attached to solid supports and use of the ionic polymers in processing of biomass.