Abstract: Provided are a universal T cell and preparation method thereof. The universal T cells comprise CAR-T and TCR-T cells, and are obtained by knocking out TCR and/or HLA and/or PD-1 proteins of T cells by a CRISPR/Cas9 genome editing technology, wherein the universal CAR-T continues to kill target cells in vivo and in vitro.
Type:
Application
Filed:
September 18, 2018
Publication date:
July 9, 2020
Applicant:
EDIGENE INC.
Inventors:
Pengfei YUAN, Fei WANG, Lingling YU, Xi DONG