Patents Assigned to EditForce, Inc.
  • Publication number: 20220289795
    Abstract: A PPR protein with high performance is provided. A PPR protein that binds to a long nucleotide sequence is provided by linking motifs in a number larger than conventionally used 7 to 14. A PPR motif is provided, of which typical examples are the followings: (A-1) a PPR motif consisting of the sequence of SEQ ID NO: 9 or 401, (C-1) a PPR motif consisting of the sequence of SEQ ID NO: 10, (G-1) a PPR motif consisting of the sequence of SEQ ID NO: 11, and (U-1) a PPR motif consisting of the sequence of SEQ ID NO: 12. These motifs are useful as PPR motifs for adenine, cytosine, guanine, and uracil in a target nucleotide sequence, respectively.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 15, 2022
    Applicants: EditForce, Inc., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Yusuke Yagi, Takahiro Nakamura
  • Publication number: 20220220166
    Abstract: In order to improve aggregation property of a PPR protein, the A6 amino acid of the 1st PPR motif from the N-terminus (M1) is made more hydrophilic. Further, the A9 amino acid of M1 is made to be a hydrophilic amino acid or glycine. The A6 amino acid is preferably asparagine or aspartic acid, and the A9 amino acid is preferably glutamine, glutamic acid, lysine, or glycine. Proteins containing such a PPR motif as M1 motif may have not only improved aggregation property, but also high binding power to a target nucleic acid.
    Type: Application
    Filed: May 29, 2020
    Publication date: July 14, 2022
    Applicants: EditForce, Inc., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Yusuke Yagi, Takayoshi Imai, Takayuki Tamai, Takahiro Nakamura, Takamasa Teramoto