Patents Assigned to Edmond Pharma s.r.l.
  • Process for the preparation of enantiomerically pure norepinephrine
    Patent number: 11390579
    Abstract: The invention concerns a new, efficient process for the preparation of enantiomerically pure norepinephrine (also known as noradrenaline), or an addition salt thereof, using a catalytic hydrogenation system under hydrogen donor transfer. The invention also discloses a novel intermediate and the process for the preparation thereof.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: July 19, 2022
    Assignee: Edmond Pharma, s.r.l.
    Inventors: Matteo Zacche', Pier Andrea Gatti, Fulvio Gerli, Davide Sbarbada, Fabio Rondina
  • A PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE NOREPINEPHRINE
    Publication number: 20220089520
    Abstract: The invention concerns a new, efficient process for the preparation of enantiomerically pure norepinephrine (also known as noradrenaline), or an addition salt thereof, using a catalytic hydrogenation system under hydrogen donor transfer. The invention also discloses a novel intermediate and the process for the preparation thereof.
    Type: Application
    Filed: April 2, 2020
    Publication date: March 24, 2022
    Applicant: Edmond Pharma, s.r.l.
    Inventors: Matteo Zacche', Pier Andrea Gatti, Fulvio Gerli, Davide Sbarbada, Fabio Rondina
  • Process for the resolution of medetomidine and recovery of the unwanted enantiomer
    Patent number: 8877941
    Abstract: A new and efficient process to obtain Medetomidine enantiomers, a selective and potent ?2-receptor agonist, is presented. Such process comprises a resolution step and a racemization reaction, to be able to recover the unwanted enantiomer which can be recycled as starting material.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: November 4, 2014
    Assignee: Edmond Pharma S.r.l.
    Inventors: Matteo Zacche', Fulvio Gerli, Pier Andrea Gatti
  • Process for the preparation of lurasidone hydrochloride
    Patent number: 8853395
    Abstract: Disclosed is a new and efficient process for the synthesis with high yields and purity of lurasidone hydrochloride, a medicament which is useful as a psychotropic substance. The process involves the preparation of lurasidone base in a reaction system not containing inorganic salts, followed by conversion of the latter to an addition salt with an organic carboxylic acid, which is finally converted to lurasidone hydrochloride.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: October 7, 2014
    Assignee: Edmond Pharma S.R.L.
    Inventors: Matteo Zacche', Fulvio Gerli, Pierandrea Gatti
  • PROCESS FOR THE PREPARATION OF LURASIDONE HYDROCHLORIDE
    Publication number: 20140243529
    Abstract: Disclosed is a new and efficient process for the synthesis with high yields and purity of lurasidone hydrochloride, a medicament which is useful as a psychotropic substance. The process involves the preparation of lurasidone base in a reaction system not containing inorganic salts, followed by conversion of the latter to an addition salt with an organic carboxylic acid, which is finally converted to lurasidone hydrochloride.
    Type: Application
    Filed: February 20, 2014
    Publication date: August 28, 2014
    Applicant: EDMOND PHARMA s.r.l.
    Inventors: Matteo ZACCHE', Fulvio GERLI, Pierandrea GATTI
  • PROCESS FOR THE RESOLUTION OF MEDETOMIDINE AND RECOVERY OF THE UNWANTED ENANTIOMER
    Publication number: 20130225832
    Abstract: A new and efficient process to obtain Medetomidine enantiomers, a selective and potent ?2-receptor agonist, is presented. Such process comprises a resolution step and a racemisation reaction, to be able to recover the unwanted enantiomer which can be recycled as starting material.
    Type: Application
    Filed: February 26, 2013
    Publication date: August 29, 2013
    Applicant: Edmond Pharma s.r.l.
    Inventors: Matteo Zacche', Fulvio Gerli, Pier Andrea Gatti
  • Polymorphs of enantiopure erdosteine
    Patent number: 8269022
    Abstract: The present invention provides novel crystalline polymorphs of enantiopure Erdosteine, referred to as Form I and Form II, and processes for the preparation thereof.
    Type: Grant
    Filed: November 10, 2008
    Date of Patent: September 18, 2012
    Assignee: Edmond Pharma S.R.L
    Inventors: Pier Andrea Gatti, Matteo Zacche′, Massimo Nicola
  • POLYMORPHS OF ENANTIOPURE ERDOSTEINE
    Publication number: 20100249435
    Abstract: The present invention provides novel crystalline polymorphs of enantiopure Erdosteine, referred to as Form I and Form II, and processes for the preparation thereof.
    Type: Application
    Filed: November 10, 2008
    Publication date: September 30, 2010
    Applicant: Edmond Pharma S.R.L
    Inventors: Pier Andrea Gatti, Matteo Zacche', Massimo Nicola
  • Salts of a glutathione alkylester and anaminoacids
    Patent number: 5525628
    Abstract: Crystalline non-hygroscopic salt of glutathione alkylester of the formula (I) ##STR1## wherein AA is an amino acid are disclosed.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: June 11, 1996
    Assignee: Edmond Pharma S.R.L.
    Inventors: Massimo Nicola, Marco Inglesi, Giancarlo B. Fregnan, Guido Vandoni
  • Inclusion complexes of dipyridamole with cyclodextrins
    Patent number: 5010064
    Abstract: Inclusion complexes of dipyridamole with beta cyclodextrins in the molar ratio of dipyridamole to cyclodextrin ranging from 1:1 to 1:12 provides higher and more consistent blood concentrations than can be achieved by the dipyridamole alone.
    Type: Grant
    Filed: June 1, 1988
    Date of Patent: April 23, 1991
    Assignee: Edmond Pharma s.r.l.
    Inventors: Giancarlo Fregnan, Guido Vandoni, Giangiacomo Torri
  • Acetylsalicylic acid thioesters, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 4563443
    Abstract: Acetylsalicylic acid thioesters having antipyretic activity and useful for the symptomatic treatment of influenza of formula: ##STR1## wherein n is zero or 1, R.sub.1 is hydrogen, methyl or carboxy and R.sub.2 is hydrogen or an acetamido group; a process for their preparation by reacting a functional derivative of acetylsalicylic acid with the suitable thiol; and pharmaceutical compositions containing them as active ingredient.
    Type: Grant
    Filed: August 9, 1983
    Date of Patent: January 7, 1986
    Assignee: Edmond Pharma S.r.l.
    Inventors: Marino Gobetti, Guido Vandoni
  • Compound having vasodilating, antiaggregating and hypocholesterolemic activities, process for the preparation thereof and pharmaceutical compositions therefrom
    Patent number: 4542141
    Abstract: The compound having formula (I) ##STR1## is obtained by reacting 1,2-diphenyl-4-[2-phenylsulfinyl)-ethyl]-4-hydroxymethyl-pyrazolidine-3,5- dione (hydroxymethylsulfinpyrazone) with nicotinic acid, in the presence of activating agents such as DCCD.(I) is endowed with marked vasodilating, antiaggregating and hypocholesterolemic properties.
    Type: Grant
    Filed: October 7, 1983
    Date of Patent: September 17, 1985
    Assignee: Edmond Pharma s.r.l.
    Inventor: Guido Vandoni