Patents Assigned to Edna McConnell Clark Foundation
  • Patent number: 4515793
    Abstract: A compound of the formula ##STR1## in which A is ##STR2## n is 1, 2 or 3, and R is phenyl optionally substituted with halogen, alkyl, phenyl, cyano, hydroxy, alkoxy, mercapto, sulfinyl, sulfonyl, amino, nitro, trifluoromethyl and/or naphthyl radicals; or a furan, thiophene, pyridine, benzofuran, dibenzothiophene or thianthrene radical,or a pharmacologically acceptable salt thereof, for treating schistosomiasis.
    Type: Grant
    Filed: July 27, 1983
    Date of Patent: May 7, 1985
    Assignee: Edna McConnell Clark Foundation
    Inventors: Leslie M. Werbel, Norman Colbry, William Turner, Donald F. Worth
  • Patent number: 4234583
    Abstract: 2-Chloro-4-(4-lower alkyl-1-piperazinyl)benzenemethanol, N.sup..omega. -oxides and their acid addition salts. These compounds are prepared by oxidizing the corresponding 2-chloro-4-(4-lower alkyl-1-piperazinyl)benzenemethanol. In addition, pharmaceutical compositions comprising said N-oxides and methods for treating schistosomiasis are disclosed.
    Type: Grant
    Filed: November 30, 1978
    Date of Patent: November 18, 1980
    Assignee: Edna McConnell Clark Foundation
    Inventors: Ernest Bueding, Leslie M. Werbel, Donald F. Worth
  • Patent number: 4158049
    Abstract: Schistosoma mansoni eggs are ground to liberate soluble egg antigens which are fractionated and purified by absorption, gel filtration and/or ion exchange chromatography, and then radioactively labelled with .sup.125 I. A fraction, identified as MSA.sub.1, is specific to the mature egg stage of Schistosoma mansoni and thus can be used to detect the presence of antibody to mature Schistosoma mansoni eggs in a patient's serum even as compared with mature eggs of different Schistosoma (species specific) or of Schistosoma mansoni worms but not mature eggs (stage specific).
    Type: Grant
    Filed: September 27, 1976
    Date of Patent: June 12, 1979
    Assignee: Edna McConnell Clark Foundation
    Inventors: Ronald P. Pelley, Kenneth S. Warren