Abstract: Silicon grids with electron-transparent SiO2 windows for use as substrates for high-resolution transmission electron microscopy of chemically-modified SiO2 surfaces are fabricated by forming an oxide layer on a silicon substrate. An aperture is defined in the silicon substrate by etching the substrate to the oxide layer. A single substrate can include a plurality of apertures that are in respective frame regions that are defined by one or more channels in the substrate. Structural or chemical functionalizations can be provided, and surface interactions observed via TEM.

Abstract: A method of reconstructing an image function on the basis of a plurality of projection profiles corresponding to a plurality of projection directions through a region of investigation, each projection profile including a series of value positions, wherein measured projection values corresponding to projection lines parallel to the respective projection direction are assigned to respective value positions and a plurality of remaining value positions are empty, comprises the steps of (a) assigning first interpolation values to the empty value positions for constructing a plurality of interpolation profiles on the basis of the projection profiles, wherein the first interpolation values are obtained from a first interpolation within a group of measured projection values having the same value position in different projection profiles, and (b) determining the image function by applying a predetermined reconstruction algorithm on the interpolation profiles.

Abstract: An imaging method for imaging a region of investigation of an object comprises the steps of generating an energy input beam with an energy beam source, irradiating the region of investigation with energy input beam components of the energy input beam along a plurality of projection directions, the energy input beam components being formed with a frame mask being arranged between the energy input beam and the object and including frame mask windows, measuring first integrated attenuation values of the energy input beam components with an outer detector device arranged outside the frame mask, measuring second integrated attenuation values of the energy input beam components with a frame mask detector device being arranged on an inner surface of the frame mask, and reconstructing an image of the region of investigation based on the first and second integrated attenuation values. Furthermore, an imaging device for imaging a region of investigation of an object is described.

Abstract: A method of reconstructing an (n+1)-dimensional image function ƒ representing a region of investigation comprises determining the image function ƒ from n-dimensional or less dimensional Radon data comprising a plurality of projection functions p?(t) measured corresponding to a plurality of predetermined projection directions (?), wherein the image function ƒ is determined as a sum of polynomials multiplied with values of the projection functions p?(t). Imaging methods, imaging devices, and computer tomography devices using this reconstruction method are described.

Abstract: The present invention relates to vinca alkaloid and analog N-oxides having activity for treating hyperproliferative disorders. Further, the invention relates to pharmaceutical compositions and methods of using vinca alkaloid and analog N-oxides, alone or in combination with one or more other active agents or treatments, to treat hyperproliferative disorders.

Abstract: In a hybrid peer-to-peer file sharing network including a receiver peer and a provider peer, the receiver sends the provider a ticket [710] obtained from a server authorizing the receiver to obtain a data object O. The receiver obtains a root value of a hash tree for the object, verifies its digital signature, and sends the provider peer a request for a block of data object O and a request for a corresponding set of hash values from the hash tree [714]. The receiver receives from the provider peer the block of O and the corresponding set of hash values of the hash tree [716] that do not contain any hash value in the local hash tree. The receiver sends the provider an acknowledgement of receipt [718], obtains a block key from the provider [720], decrypts the block, verifies the integrity of the block using the subset of hash values and the local hash tree for O, and updates the local hash tree by adding the subset of hash values to the local hash tree, as well as any newly calculated hash values [722].

Abstract: In a hybrid peer-to-peer file sharing network including a receiver peer and a provider peer, the receiver sends the provider a ticket [710] obtained from a server authorizing the receiver to obtain a data object O. The receiver obtains a root value of a hash tree for the object, verifies its digital signature, and sends the provider peer a request for a block of data object O and a request for a corresponding set of hash values from the hash tree [714]. The receiver receives from the provider peer the block of O and the corresponding set of hash values of the hash tree [716] that do not contain any hash value in the local hash tree. The receiver sends the provider an acknowledgement of receipt [718], obtains a block key from the provider [720], decrypts the block, verifies the integrity of the block using the subset of hash values and the local hash tree for O, and updates the local hash tree by adding the subset of hash values to the local hash tree, as well as any newly calculated hash values [722].

Abstract: As demonstrated herein, the ligand exchange chemistry of phosphine-stabilized Au11 clusters with ?-functionalized thiols is a powerful synthetic method that provides convenient access to a diverse family of functionalized Au11 clusters. The general nature of the presented ligand exchange approach, in combination with the ease preparation, makes this approach of broad utility. The approach is general and shows the high tolerance for a wide variety of functional groups. Mechanistic studies provided conclusive evidence that the Au11 core of the precursor particle remains intact during ligand exchange and showed that the ligand exchange of these particles follows a different pathway than for ligand exchanges of larger gold nanoparticles such as “Au101(PPh3)21Cl5”. Optical studies of the products show a strong dependence on the nature of the stabilizing thiol ligands.

Abstract: Metallic clusters can be produced by contacting a metal salt such as a metal nitrate with an organic reducing agent. Metals can be selected from a group consisting of metals exhibiting octahedral coordination, and nitrates of the selected metal or metals are contacted with, for example nitrosobenzene. Binary, tertiary, or other clusters can be produced.

Abstract: A structure for high performance light emitting electrochemical cells comprises at least two active layers of mixed ionic/electronic conducting materials, at least one of which is electroluminescent. The active layers are sandwiched between ion blocking electrodes, typically metal and/or transparent conducting oxide, that are electrically but not ionically conductive. Application of bias to the electrodes results in the polarization of ions at the electrodes thereby generating a field to drive the injection of electronic carriers into the active layer. The injected electron and holes recombine within the active layers to emit light. The ability to balance electron and hole injection in the design of such devices provides for optimal light emission efficiency.

Abstract: An asymmetric mirror is composed of a dielectric substrate [500] and a coating [502] on the dielectric substrate. Within an operational wavelength range ??, the mirror has a transmission symmetry ?T=0% and a reflection asymmetry ?R>10%, where the reflection asymmetry ?R varies by less than 5% within the operational wavelength range ??. In addition, the wavelength range ?? is substantially broad, i.e., satisfies ??/?max>10%. The coating [502] is a metamaterial having structural features smaller than the smallest operational wavelength, e.g., a nano-structured metamaterial such as a photonic crystal or a disordered nano-composite of a metal and a dielectric. In a preferred embodiment, the coating [502] is semi-continuous with a filling factor p between 70% and 75%. The dielectric may be, for example, air, vacuum, an electro-optic polymer, an optical gain material, an electro-active material, or a semiconductor.

Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.

Abstract: Antenna assemblies for magnetic resonance signals comprise a non-resonant loop antenna and a high impedance differential amplifier. The amplifier can include first and second high electron mobility transistors that have gates coupled to an antenna loop that is defined on a rigid substrate. The non-resonant loop has an effective length of less than about 1/10 of a wavelength of a signal to be detected. Arrays of such loops can be defined on the rigid substrate, and HEMTs for the loops secured to the substrate.

Abstract: A method for forming arrays of metal, alloy, semiconductor or magnetic nanoparticles is described. An embodiment of the method comprises placing a scaffold on a substrate, the scaffold comprising, for example, polynucleotides and/or polypeptides, and coupling the nanoparticles to the scaffold. Methods of producing arrays in predetermined patterns and electronic devices that incorporate such patterned arrays are also described.

Abstract: A heat exchanger according to certain embodiments includes an outer portion formed of at least one inflatable cell and an inner portion. The inflatable cell has inner and outer surfaces that are separated from each other and at least partially support the outer portion when inflated. The outer portion defines a first interior passage configured to convey fluid. The inner portion is positioned within the outer portion, the inner portion defining a second interior passage configured to convey fluid.

Abstract: An irradiation method, in particular for imaging a region of investigation (2) of an object (1), comprises generating at least one energy input beam (3) with at least one energy input beam source (210), wherein the at least one energy input beam (3) comprises a plurality of individual energy input beam components (3.1, 3.2, 3.3, . . . ), and irradiating the region of investigation (2) with the at least one energy input beam (3) along a plurality of projection directions, wherein the energy input beam components (3.1, 3.2, 3.3, . . . ) are formed with at least one beam mask (211) made of an energy input shielding material with through holes. Furthermore, imaging methods and devices for irradiating or imaging the object are described.

Abstract: This disclosure provides methods for detecting and localizing DNA mutations by DNA microarray. In various embodiments, the described methods include use of restriction endonuclease(s) and/or mismatch-recognition nuclease(s) to detect and/or localize mutations. In one representative method, reference and target DNA are digested using one or more restriction endonucleases, resultant DNA strands are labeled (e.g., using a DNA polymerase), and the labeled mixture of DNAs is hybridized to a microarray. In another representative method, reference and target DNA are denatured and annealed to form a mixture containing heteroduplex DNA, one or more mismatch-recognition nuclease(s) are used to nick or cleave at least a portion of the heteroduplex DNA, resultant DNA strands are labeled (e.g., using a DNA polymerase) and the labeled mixture of DNAs is hybridized to a microarray.

Abstract: Engineered fluorescent proteins, nucleic acids encoding them and methods of use are provided.

Abstract: An optical data signal can be sampled by linearly combining the optical data signal with optical sampling pulses, and delivering the combination to first and second balanced detectors. The optical data signal and the optical sampling pulse are configured to have a first phase difference at the first balanced detector and a second phase difference at the second balanced detector. Typically, a difference between the first phase difference and the second phase difference is configured to be about 90 degrees. In-phase and quadrature balanced detector outputs can be combined as a sum of squares to produce a linear sampling signal representative of data signal intensity, and the sample pulses can be configured to temporally step through the optical data signal so that a sampled representation of the optical data signal is obtained.

Abstract: A method for forming arrays of metal, alloy, semiconductor or magnetic clusters is described. The method comprises placing a scaffold on a substrate, the scaffold comprising, for example, polynucleotides and/or polypeptides, and coupling the clusters to the scaffold. Methods of producing arrays in predetermined patterns and electronic devices that incorporate such patterned arrays are also described.