Abstract: Provided are a transthyretin tetramer stabilizing agent and a preventing agent or progression suppressing agent for transthyretin amyloidosis. The present invention relates to a transthyretin tetramer stabilizing agent including glabridin, glabrene, and glabrol, and to a preventing agent or progression suppressing agent for transthyretin amyloidosis including glabridin, glabrene, and glabrol.
Type:
Application
Filed:
April 6, 2023
Publication date:
August 3, 2023
Applicants:
KANEKA CORPORATION, EDUCATIONAL FOUNDATION KYUSHU BUNKA GAKUEN, NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
Abstract: Provided are a transthyretin tetramer stabilizing agent and a preventing agent or progression suppressing agent for transthyretin amyloidosis. The present invention relates to a transthyretin tetramer stabilizing agent including a hydrophobic licorice extract containing a licorice glabra polyphenol, and to a preventing agent or progression suppressing agent for transthyretin amyloidosis including a hydrophobic licorice extract containing a licorice glabra polyphenol.
Type:
Application
Filed:
April 6, 2023
Publication date:
August 3, 2023
Applicants:
KANEKA CORPORATION, EDUCATIONAL FOUNDATION KYUSHU BUNKA GAKUEN, NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
Abstract: A biometric method includes: a step (1) for administering, to a target organism from the outside thereof, one of (i) a target molecule A having both an unpaired electron and a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19F, and (ii) a target molecule B and a radical molecule C, the target molecule B having no unpaired electron, and further having a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19F, the radical molecule C having an unpaired electron; and a step (2) for causing electron spin resonance in the unpaired electron of the target molecule A or the radical molecule C by irradiating electromagnetic waves to the target organism, subsequently triggering nuclear magnetic resonance in the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19F in one of the target molecule A and the target molecule B, and further, measuring nuclear magnetic resonance signals.
Type:
Grant
Filed:
March 1, 2017
Date of Patent:
February 16, 2021
Assignees:
Educational foundation Kyushu Bunka Gakuen, JAPAN REDOX LIMITED