Abstract: The present invention provides media for inactivating pathogens found within protein-containing biological fluids. The media of the present invention preserve the structural integrity and biological activity of labile proteins while simultaneously exhibiting potent disinfectant activity. The media of the present invention comprise iodinated chromatographic media, particularly ion exchange media. The invention further provides methods for disinfecting biological fluids.
Type:
Grant
Filed:
March 7, 1997
Date of Patent:
August 1, 2000
Assignees:
American National Red Cross, Amersham Pharmacia Biotech, Inc., Edward Shanbrom
Inventors:
Edward Shanbrom, Shirley I. Miekka, Robert Pollock, William N. Drohan, Timothy W. Horton
Abstract: Polyethylene glycol or poly(oxyethylene)poly(oxypropylene) glycol block copolymers or mixtures thereof in a suitable buffer such as citrated saline, are added to blood plasma to preserve and protect blood coagulation factors and other proteins.
Abstract: Polyethylene glycol or poly(oxyethylene)poly(oxypropylene) glycol block copolymers or both and heparin in a suitable buffer, such as citrated saline, are added to blood plasma to preserve and protect blood coagulation factors and other proteins.
Abstract: Polyethylene glycol or poly(oxyethylene)poly(oxypropylene) glycol block copolymers or mixtures thereof in a suitable buffer such as citrated saline, are added to blood plasma to preserve and protect blood coagulation factors and other proteins.
Abstract: Polyethylene glycol or poly(oxyethylene)poly(oxypropylene) glycol block copolymers or both and heparin in a suitable buffer, such as citrated saline, are added to blood plasma to preserve and protect blood coagulation factors and other proteins.