Abstract: The present invention provides a tool and method for performing a lumbar puncture. The tool may include a first arm and a second arm and may form a T-shape. The first arm may be longer than the second arm. Also included is a projection extending from one of the arms. The projection has a downward angle and a passageway that is sized to accommodate a needle. The tool is configured to maintain the perpendicular placement of a needle between vertebrae and a preferred angle of insertion of about 15° during a procedure.

Abstract: A system implemented on a distributed computer network for capturing experiences of healthcare trainees. The system includes input devices having an interface for interacting with a user including an input screen having data input fields, selection fields and activation buttons and output screens. Also included are one or more back-end databases configured to store input data from the input devices and to provide output data to the input devices.

Abstract: Disclosed are recombinant bacteriophage constructs and related exogenous peptide sequences for generating immune responses against CD47. The disclosed recombinant phage constructs bind to antibodies against CD47 and can be administered to an animal to generate an immune response against CD47, including generating anti-CD47 antibodies. The disclosed recombinant phage may comprise an amino acid sequence of CD47, epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against CD47 including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.

Abstract: The present invention provides a tool and method for performing a lumbar puncture. The tool may include a first arm and a second arm and may form a T-shape. The first arm may be longer than the second arm. Also included is a projection extending from one of the arms. The projection has a downward angle and a passageway that is sized to accommodate a needle. The tool is configured to maintain the perpendicular placement of a needle between vertebrae and a preferred angle of insertion of about 15° during a procedure.

Abstract: The present invention provides a system for training tendons and muscles of a kinetic chain including the finger tips through the elbow, including muscles, ligaments, and tendons. The system uses finger attachments to secure the digits or other anatomical components to one or more resistance members that allow the attachments to be positionable in any direction with respect to one another when a force is applied.

Abstract: The present invention provides a tool and method for performing a lumbar puncture. The tool may include a first arm and a second arm and may form a T-shape. The first arm may be longer than the second arm. Also included is a projection extending from one of the arms. The projection has a downward angle and a passageway that is sized to accommodate a needle. The tool is configured to maintain the perpendicular placement of a needle between vertebrae and a preferred angle of insertion of about 15° during a procedure.

Abstract: A system implemented on a distributed computer network for capturing experiences of healthcare trainees. The system includes input devices having an interface for interacting with a user including an input screen having data input fields, selection fields and activation buttons and output screens. Also included are one or more back-end databases configured to store input data from the input devices and to provide output data to the input devices.

Abstract: The present invention provides a tool and method for performing a lumbar puncture. The tool may include a first arm and a second arm and may form a T-shape. The first arm may be longer than the second arm. Also included is a projection extending from one of the arms. The projection has a downward angle and a passageway that is sized to accommodate a needle. The tool is configured to maintain the perpendicular placement of a needle between vertebrae and a preferred angle of insertion of about 15° during a procedure.

Abstract: The present invention provides a system for training tendons and muscles of a kinetic chain including the finger tips through the elbow, including muscles, ligaments, and tendons. The system uses finger attachments to secure the digits or other anatomical components to one or more resistance members that allow the attachments to be positionable in any direction with respect to one another when a force is applied.

Abstract: An HDAC6 inhibitor (a compound of Formula I) is shown to reduce the pathogenesis associated with the B cell mediated autoimmune disease, systemic lupus erythematosus (SLE) Administration of a compound of Formula I attenuated many of the symptoms characteristic of SLE including splenomegaly, abnormal B cell differentiation, an increase in the number double-negative thymic T cells, an increase in the level of auto-antibodies such as anti-dsDNA, immune complex-mediated glomerulonephritis and an increase in inflammatory cytokine production. Treatment with a compound of Formula I also increased the number of the subject's splenic Treg cells while removing circulating auto-antibodies Inhibition of HDAC6 altered bone marrow B cell differentiation by increasing the percentage of cells in the early-stage developmental fractions of both pro- and pre-B cells. These results demonstrate HDAC6 inhibition with a compound of Formula I can treat SLE disease by altering aberrant T and B cell differentiation.

Abstract: A method of treating or preventing neurological injury in a subject who has suffered a stroke is described. The method includes administering a therapeutically effective amount of cerium oxide nanoparticles to the subject. Methods for prophylaxis against neurological injury from stroke, and methods for treating or preventing cardiovascular disease by administration of a therapeutically effective amount of cerium oxide nanoparticles are also described.

Abstract: The present invention provides a system and method for active propulsion of devices, such as endoscopes, along cavities, such as body lumens. The propulsion system can be attached to a commercially available endoscope, or be provide affixed together, and moves the endoscope in a lumen by pulling it forward. The present invention further provides a method of diagnosing diseases and disorders, and treatment of diseases and disorders, using a device according to the invention.

Abstract: A method of treating or preventing neurological injury in a subject who has suffered a stroke is described. The method includes administering a therapeutically effective amount of cerium oxide nanoparticles to the subject. Methods for prophylaxis against neurological injury from stroke, and methods for treating or preventing cardiovascular disease by administration of a therapeutically effective amount of cerium oxide nanoparticles are also described.