Abstract: A device for applying a plurality of hemoclips to blood vessels and the like includes a longitudinally disposed frame having a pistol grip and an opposed trigger lever extending from the proximal end thereof. A narrow, internal passageway extends the length of the frame, from a loading opening at the proximal end to a fixed lower jaw at the distal end of the frame. A plurality of U-shaped hemoclips is disposed in the passageway with the points thereof extending toward the distal jaw portion. An upper jaw extends from a clevis member which straddles the frame and is pivotally joined to an upper medial portion thereof. The trigger lever is pivotable to cause the clevis member to pivot upwardly and the upper jaw to close upon the lower jaw to crush a hemoclip disposed therebetween.