Patents Assigned to Edwards Lifesciences Corporation
  • Publication number: 20230285144
    Abstract: A prosthetic device, such as a prosthetic heart valve, can include a frame that is radially expandable and compressible between a radially compressed state and a radially expanded state. In some examples, the prosthetic device can include locking mechanisms that are configured to hold the prosthetic device in a radially expanded state. In some examples, the locking mechanisms can be integrated into the frame of the prosthetic device.
    Type: Application
    Filed: July 8, 2021
    Publication date: September 14, 2023
    Applicant: Edwards Lifesciences Corporation
    Inventors: Haim Yushtein, Anatoly Dvorsky, David Maimon, Noam Nir, Alon Ben-Yosef
  • Publication number: 20230270545
    Abstract: A prosthetic valve delivery apparatus can comprise a handle, an outer shaft extending distally from the handle, a gear mechanism arranged distal to the outer shaft, an input torque shaft extending distally from the handle through the outer shaft and having a distal end portion operatively connected to the gear mechanism, and a plurality of output torque shafts operatively connected to and extending distally from the gear mechanism. The gear mechanism is configured to transfer rotational motion from the input torque shaft to the plurality of output torque shafts.
    Type: Application
    Filed: May 5, 2023
    Publication date: August 31, 2023
    Applicant: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Oren Cohen, Ofir Witzman, Yair A. Neumann
  • Publication number: 20230255758
    Abstract: A crimping device for a prosthetic heart valve can comprise an annular outer frame and an inner frame extending through the outer frame, the inner frame comprising first and second axial end portions and a plurality of jaw guides extending therebetween, where the inner frame defines a central opening extending therethrough. The crimping device can comprise a plurality of jaws operatively coupled to the inner and outer frames, each jaw having an inner portion positioned within the central opening of the inner frame and an engagement portion configured to slide along a respective jaw guide, each jaw guide comprising an inclined guiderail extending between the first and second axial end portions. Relative axial motion between the outer and inner frames causes radial motion of the jaws for crimping a prosthetic device positioned within the central opening.
    Type: Application
    Filed: April 28, 2023
    Publication date: August 17, 2023
    Applicant: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Robert C. Taft, Travis Zenyo Oba
  • Patent number: 11684471
    Abstract: Embodiments of a prosthetic heart valve comprise an annular main body, an atrial cap extending radially outwardly from the atrial end of the main body, and a plurality of ventricular anchors extending outwardly from the ventricular end of the main body. Each ventricular anchor can have a proximal end portion connected to the ventricular end, an intermediate portion extending away from the atrial end and then back toward the atrial so as to define a first bend, and a free distal end portion that extends from the intermediate portion. The distal end portion can comprise a first section, a second section, and a second bend between the first and second sections, the first section extending from the intermediate portion in a direction toward the atrial end and radially away from the main body.
    Type: Grant
    Filed: June 16, 2020
    Date of Patent: June 27, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Alexander H. Cooper, Matthew A. Peterson, William C. Brunnett
  • Patent number: 11684472
    Abstract: A sizing tool for use in implanting a composite valved conduit having a prosthetic heart valve on a distal end attached to a conduit graft that extends to a proximal end. The tool includes a proximal handle and a distal shaft, a prosthetic heart valve sizer having an axis affixed to a distal end of the shaft, and a conduit graft replica having an axis mounted on the shaft proximal to the heart valve sizer. A method of securing a composite valved conduit includes introducing to an excised ascending aorta the sizing tool, measuring the aortic annulus with the prosthetic heart valve sizer, and determining whether the coronary arteries have sufficient length or whether an additional tubular coronary extension segment is required to add to one or both of the ends of the coronary arteries by extending the coronary arteries toward the conduit graft replica.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: June 27, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Ruggero De Paulis, Michael C. Murad
  • Patent number: 11684474
    Abstract: Disclosed herein are embodiments of a delivery system which can be used to recapture and/or reposition a replacement valve, such as a replacement mitral valve, after initial deployment of the valve. Embodiments of the disclosure can use the crimping/tensioning of sutures in order to re-crimp the replacement valve after release, though longitudinal or rotational forces.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: June 27, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Harish Manickam Srinimukesh, Travis Zenyo Oba, David Robert Landon, Glen T. Rabito
  • Patent number: 11678981
    Abstract: An improved holder and storage system for a tissue-type prosthetic mitral heart valve that constricts the commissure posts of the valve and prevents suture looping. A rod axially movable relative to the holder tensions lengths of attachment sutures that extend between the commissure post tips to create a tent and flex the tips inward, thus helping to prevent looping of any of an array of pre-implanted sutures around the leading tips during delivery of the valve. The holder has a safety mechanism that prevents valve delivery before the rod is deployed. One embodiment automatically deploys the rod upon opening a storage jar. One embodiment permits a delivery handle to directly deploy the rod, while another uses a separate worm screw and coupling. A holder clip that attaches to a packaging sleeve may be formed of flexible members meshed together from which the heart valve and holder are easily pulled free to eliminate a step of decoupling the clip from the sleeve.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: June 20, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Michael C. Murad, Emil Karapetian, Wesley V. Adzich
  • Patent number: 11666434
    Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: June 6, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Ziv Yohanan, Tamir S. Levi, Netanel Benichou, Michael Bukin, Nikolai Gurovich, Elena Sherman
  • Patent number: 11666436
    Abstract: A device for crimping a radially expandable and collapsible prosthetic valve comprises a crimping loop having a first end portion, a second end portion, and a loop portion extending between the first and second end portions and defining an opening configured to receive the prosthetic valve. The crimping loop is movable between a first state in which the opening has a first diameter and a second state in which the opening has a second diameter smaller than the first diameter such that when the prosthetic valve is positioned within the loop portion, movement of the crimping loop from the first state to the second state is effective to reduce a diameter of the prosthetic valve. A method for crimping a prosthetic valve comprises reducing a diameter of an opening of a crimping loop, thereby radially compressing an at least partially expanded prosthetic valve disposed within the opening.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: June 6, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: David Maimon, Ron Sharoni, Tamir S. Levi, Emil Karapetian, Tri D. Tran, Tung Le
  • Patent number: 11666325
    Abstract: The present disclosure relates to automated systems, devices, and methods of sewing a target device such as a prosthetic implant device. The systems and methods include forming a stitch on the target device, adjusting a thread coupled to a needle used to form the stitch so that the thread is clear of (e.g., does not interfere with) a path of the needle, and applying a targeted tension to the thread to tension the stitch on the target device. The suturing process can also include providing different targeted tensions during formation of the stitch. The suturing process can also include providing different targeted tensions at different stages of the formation of the stitch to aid in forming the stitch, to clear the needle path of the thread, and/or to hold the stitch in place in preparation for the next stitch.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: June 6, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Wei Nee Koh, Ping-Yang Shih, Marius Tomas Petrulis, Sam Nicolas Sarian
  • Patent number: 11666437
    Abstract: A delivery cylinder for a prosthetic implant can include a first tubular portion and a second tubular portion. The second tubular portion has a plurality of strut members coupled to the first tubular portion that define a volume for containing the prosthetic implant in a radially compressed state. The strut members can include respective flex regions configured such that application of force to the strut members causes deformation of the flex regions and corresponding radially inward or outward movement of the strut members relative to a longitudinal axis of the delivery cylinder between an expanded configuration and a contracted configuration.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: June 6, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Arvin T. Chang, Sam Sok, Amanda Kristine Anderson White, Ajay Chadha
  • Patent number: 11660185
    Abstract: A prosthetic spacer assembly includes a spacer body, a first anchor, and a second anchor. The first anchor and the second anchor are each connected to the spacer body. The first anchor is configured to capture a first native valve leaflet between the first anchor and the spacer body. The second anchor is configured to capture a second native valve leaflet between the second anchor and the spacer body.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: May 30, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Mark Chau, Marlowe E. Patterson, Seung-Beom Yi, Stephen C. Geist, Travis Zenyo Oba
  • Patent number: 11660188
    Abstract: Prosthetic heart valves are described. Prosthetic heart valves can include radially expandable and compressible inner and outer metal frames. The inner frame can be disposed within a lumen of the outer frame and can be coupled to the outer frame. An outflow end of the inner frame can be coupled to and/or located at an outflow end of the outer frame. An end portion of the inner frame can be spaced radially inwardly from an inner surface of the outer frame, such that a radial gap exists between the inner surface of the outer frame and an outer surface of the inner frame. Prosthetic heart valves can further include a plurality of leaflets disposed within and supported by the inner frame, such as by commissure posts of the inner frame.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: May 30, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Netanel Benichou, Stanton J. Rowe, Sean Chow
  • Patent number: 11660192
    Abstract: The present teachings provide systems, devices, and methods for reshaping the heart and reducing valve regurgitation. A device can be positioned proximate the heart and have a delivery profile and an inflated profile. The device can have a primary cavity and a secondary cavity, and an adhesive inside the secondary cavity. An injectable medium can be injected to the primary cavity of the device. As the primary cavity is filled, the adhesive is forced out of the secondary cavity to adhere the device. The inflated device can exert pressure on the heart, change the shape of a valve annulus, and allow a better coaptation of the valve leaflets.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: May 30, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Michael W. Sutherland, Steven D. Cahalane, Morgan House
  • Patent number: 11660191
    Abstract: A distal end of a guide catheter is transvascularly advanced into a left ventricle of a heart of a subject. While the distal end of the guide catheter remains disposed in the left ventricle, a first tissue anchor of an implant is deployed from the distal end of the guide catheter. Subsequently, the guide catheter is retracted while progressively exposing the implant. Subsequently, a second tissue anchor of the implant is anchored to a posterior annulus of a mitral valve of the heart by deploying at least part of the second anchor within a left atrium of the heart, such that the implant extends from the first tissue anchor, over an atrial side of a posterior leaflet of the mitral valve, and to the second tissue anchor. Other embodiments are also described.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: May 30, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Aaron M. Call, Joseph P. Lane
  • Patent number: 11660190
    Abstract: Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: May 30, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Paul A. Spence, Donald S. Baim, Edward I. McNamara, Hiroatsu Sugimoto, Joseph P. Lane, Jason H. Robinson, Aaron M. Call, Steven D. Cahalane, Mark Maguire, Kate E. Cutuli
  • Patent number: 11654023
    Abstract: A prosthetic heart valve includes a frame that is radially collapsible and expandable between a collapsed configuration and an expanded configuration, and defines a longitudinal axis. A leaflet structure situated within the frame, and a sealing member is disposed around the frame. The sealing member can include a first portion extending circumferentially around a portion of the frame, the first portion being configured to resiliently stretch in a direction along the longitudinal axis between a first state corresponding to the expanded configuration of the frame and a second state corresponding to the collapsed configuration of the frame. The sealing member can include a second portion extending circumferentially around a portion of the frame, the second portion being configured to resiliently stretch in a circumferential direction between a first state corresponding to the collapsed configuration of the frame and a second state corresponding to the expanded configuration of the frame.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: May 23, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Shahram Zamani, Michael Bukin, Sandip Vasant Pawar
  • Patent number: 11654020
    Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible to a limited degree for delivery and expandable post-implant to facilitate valve-in-valve (ViV) procedures. The hybrid heart valves eliminate earlier structural bands, which both reduces manufacturing time and facilitates ViV procedures.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: May 23, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Brian S. Conklin, Qinggang Zeng, Myron Howanec, Jr., Grace Myong Kim
  • Patent number: 11648111
    Abstract: An implantable prosthetic valve includes a radially collapsible and expandable annular frame having three commissure attachment posts and four rows of circumferential struts. The rows include a first row, a second row downstream of the first row, a third row downstream of the second row, and a fourth row downstream of the third row and defining an outflow end of the frame. Each row of circumferential struts includes angled struts arranged in a zig-zag pattern. A leaflet structure includes three leaflets forming three commissures, each commissure being connected to one of the commissure attachment posts only at locations along the commissure attachment posts between a first plane that is perpendicular to a longitudinal axis of the frame and intersects crowns of the third row of struts and a second plane that is perpendicular to the longitudinal axis and intersects crowns of the fourth row of struts.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: May 16, 2023
    Assignee: Edwards Lifesciences Corporation
    Inventors: Ilia Hariton, Netanel Benichou, Yaacov Nitzan, Bella Felsen, Diana Nguyen-Thien-Nhon, Rajesh A. Khanna, Son V. Nguyen, Tamir S. Levi, Itai Pelled
  • Patent number: 11648116
    Abstract: A valved conduit including a bioprosthetic aortic heart valve connected to a tubular conduit graft forming an ascending aorta. The conduit graft may attach to the heart valve in a manner that facilitates a redo operation in which the valve is replaced with another valve. A sewing ring may be pre-attached to the inflow end of the graft, and then the valve connected to a delivery holder advanced into the graft and secured to the sewing ring. Dry bioprosthetic valves coupled with conduit grafts sealed with a bioresorbable medium can be stored with the delivery holder.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: May 16, 2023
    Assignee: EDWARDS LIFESCIENCES CORPORATION
    Inventors: Michael C. Murad, Hilda Z. Fann, Mark Van Nest, John X. Wang, Derrick Johnson