Patents Assigned to Edwards Lifesciences Corporations
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Patent number: 11612485Abstract: A system for implanting a repair device onto a native valve of a natural heart to repair the native valve of a patient during a non-open-heart procedure. The system includes a delivery catheter and a valve repair device. The valve repair device is disposed inside the delivery catheter. The valve repair device includes a pair of paddles and a pair of gripping members. The pair of paddles are movable between an open position and a closed position. The pair of paddles and the pair of gripping members are configured to secure the valve repair device to leaflets of the native valve. The pair of paddles are compressed inside the delivery catheter. Each paddle of the pair of paddles is configured to expand upon exiting the delivery catheter to increase the surface area of each paddle.Type: GrantFiled: March 13, 2020Date of Patent: March 28, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Asher L. Metchik, Gregory Scott Tyler, II, Matthew T. Winston, Sergio Delgado, Lauren R. Freschauf, Eric Robert Dixon, Alexander J. Siegel
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Patent number: 11607310Abstract: In a representative embodiment, a method comprises implanting first and second inflatable bodies within an annulus of a native heart valve by securing the inflatable bodies to tissue of the native heart valve with sutures, and implanting a prosthetic heart valve between the inflatable bodies such that the prosthetic heart valve is retained within the annulus by the inflatable bodies.Type: GrantFiled: November 12, 2020Date of Patent: March 21, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: David M. Taylor, Alexander J. Siegel, Thomas V. Doherty, Christopher J. Olson, Yoon Hee Kwon
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Patent number: 11602431Abstract: An exemplary valve repair device for repairing a native valve of a patient includes a coaption element, a pair of paddles, and barb portions. The barb portions extend directly from at least one of the coaption element and the pair of paddles.Type: GrantFiled: October 25, 2018Date of Patent: March 14, 2023Assignee: Edwards Lifesciences CorporationInventors: Sergio Delgado, Eric Robert Dixon, David M. Taylor, Asher L. Metchik, Matthew T. Winston, Gregory Scott Tyler, II, Lauren R. Freschauf, Alexander J. Siegel
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Patent number: 11596514Abstract: An expandable stent for implantation in a right ventricular outflow tract includes a frame having a plurality of struts that define a repeating pattern of cells. The repeating pattern of cells comprises a column of exactly three generally diamond shaped cells positioned in end-to-end alignment, and a column of exactly two generally diamond shaped cells positioned in end-to-end alignment. The frame has a substantially hourglass shape with a narrow portion in between a proximal end portion and a distal end portion, wherein the proximal end portion and the distal end portion are configured to expand radially outward to contact a right ventricular outflow tract.Type: GrantFiled: January 25, 2022Date of Patent: March 7, 2023Assignee: Edwards Lifesciences CorporationInventors: Dustin P. Armer, Michael D. Franklin, Sergio Delgado, Abhijeet Joshi, Dinesh L. Sirimanne, Russell T. Joseph, Eason Michael Abbott, Tram Ngoc Nguyen, Son V. Nguyen, Hien Tran Ngo, Vivian Tran, Charles L. Bowman, Stanton J. Rowe
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Patent number: 11596515Abstract: Prosthetic heart valves are described. Prosthetic heart valves can include radially expandable and compressible inner and outer metal frames. The inner frame can be disposed within a lumen of the outer frame and can be coupled to the outer frame. An outflow end of the inner frame can be coupled to and/or located at an outflow end of the outer frame. An end portion of the inner frame can be spaced radially inwardly from an inner surface of the outer frame, such that a radial gap exists between the inner surface of the outer frame and an outer surface of the inner frame. Prosthetic heart valves can further include a plurality of leaflets disposed within and supported by the inner frame, such as by commissure posts of the inner frame.Type: GrantFiled: March 25, 2022Date of Patent: March 7, 2023Assignee: Edwards Lifesciences CorporationInventors: Netanel Benichou, Stanton J. Rowe, Sean Chow
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Patent number: 11589988Abstract: This application relates to methods, systems, and apparatus for replacing native heart valves with prosthetic heart valves and treating valvular insufficiency. In a representative embodiment, a support frame configured to be implanted in a heart valve comprises a main body formed by formed by a plurality of inner members forming an inner clover and a plurality of outer members forming an outer clover. The support frame can include gaps located between inner members of the plurality of inner members and outer members of the plurality of outer members. The inner clover can be radially inside the outer clover, and the outer clover can have larger dimensions than the inner clover. The support frames herein can be radially expandable and collapsible.Type: GrantFiled: January 6, 2020Date of Patent: February 28, 2023Assignee: Edwards Lifesciences CorporationInventors: Emil Karapetian, Maria Charles Vija Stanislaus, Gregory Bak-Boychuk, Christopher J. Olson, Cristobal R. Hernandez, William C. Brunnett, Netanel Benichou, Lauren R. Freschauf, Alexander J. Siegel, Stanton J. Rowe, Alison S. Curtis
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Patent number: 11589986Abstract: Embodiments of the present disclosure provide a delivery apparatus for a prosthetic heart valve. Disclosed delivery apparatuses can include a handle, a first shaft extending from the handle, a second shaft disposed around the first shaft, and a valve cover. The valve cover can be coupled to a distal end portion of the first shaft and can be configured to house a prosthetic heart valve in a radially compressed state. The valve cover can have an outer diameter greater than an outer diameter of the second shaft, and the first shaft and valve cover can be movable together in an axial direction relative to the second shaft.Type: GrantFiled: August 12, 2020Date of Patent: February 28, 2023Assignee: Edwards Lifesciences CorporationInventors: Philippe Marchand, David M. Taylor, Robert Milich, David J. Evans, Christopher Chia, Ronaldo C. Cayabyab, Robert Bowes
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Patent number: 11590260Abstract: Methods for treating a bioprosthetic tissue are described herein. The methods comprise contacting the bioprosthetic tissue with at least one nucleophile and/or at least one electrophile in the presence of a catalytic system comprising at least one or a combination of a fluoride-based salt, a cesium-based salt, a potassium-based salt, a rubidium-based salt, or a carbonate-based salt. The methods may be used to alter functional groups on biological tissue which represent actual and potential calcium binding sites and also processes for cross-linking bioprosthetic tissue. Both processes may be used in conjunction with known fixative techniques, such as glutaraldehyde fixation, or may be used to replace known fixative techniques.Type: GrantFiled: March 22, 2019Date of Patent: February 28, 2023Assignee: Edwards Lifesciences CorporationInventors: Dengfeng Xu, Jeffrey S. Dove
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Patent number: 11590550Abstract: An apparatus for crimping a radially expandable stent includes a pressure vessel, shaping balloon, and mandrel. The mandrel is configured to slidingly receive a stent thereon, and to be slidingly advanced into the pressure vessel. The shaping balloon is inflated to radially compress the stent onto the form of the mandrel; such compression need not be uniform. Pressurization of the shaping balloon facilitates the expansion of the balloon to achieve compression of the stent, with depressurization of the shaping balloon causing the balloon to return to an unexpanded state.Type: GrantFiled: January 14, 2020Date of Patent: February 28, 2023Assignee: Edwards Lifesciences CorporationInventor: Harvey H. Chen
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Patent number: 11583396Abstract: A prosthetic apparatus for implantation in a native heart valve includes a main body for placement within the native annulus. The main body is compressible to a radially compressed state for delivery into the heart and is self-expandable from the compressed state to a radially expanded state for implantation. A valve structure is mounted within a lumen of the main body and preferably forms three leaflets made of pericardium. Ventricular anchors are coupled to a ventricular end portion of the main body. The ventricular anchors are adapted to be straightened for delivery to the native heart valve and are biased to spring back to a pre-formed bent shape for capturing the native heart valve leaflets between the main body and the ventricular anchors. An atrial sealing member may be provided along an atrial portion of the main body for impeding the flow of blood between the main body and the native annulus.Type: GrantFiled: August 31, 2020Date of Patent: February 21, 2023Assignee: Edwards Lifesciences CorporationInventors: Mark Chau, Marlowe E. Patterson, Seung-Beom Yi, Stephen C. Geist, Travis Zenyo Oba
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Patent number: 11576772Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander.Type: GrantFiled: January 27, 2020Date of Patent: February 14, 2023Assignee: Edwards Lifesciences CorporationInventors: Visith Chung, Da-Yu Chang, Brian S. Conklin, Grace Myong Kim, Louis A. Campbell, Donald E. Bobo, Jr., Myron Howanec, Jr., David S. Lin, Peng Norasing, Francis M. Tran, Mark Van Nest, Thomas Chien, Harvey H. Chen, Isidro L. Guerrero, Derrick Johnson, Paul A. Schmidt
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Patent number: 11576784Abstract: An active annuloplasty ring holder having a template that can be folded or pivoted to the side allowing the template to align longitudinally with the handle and enter the patient's chest through a small incision. The holder may include a mechanism to remotely detach sutures fastening the ring to the holder, thereby detaching the ring while avoiding the risk associated with introducing a scalpel into the operating field. A detachment mechanism may include a movable pin actuated by a pull wire that releases a plurality of holding sutures, or a hot wire, knives, or pull wire that severs the sutures. The holder may have a built-in light source for better visualization of the ring inside the heart. The holder may also have an optical means of visualizing the inside of the heart from the proximal end of the handle.Type: GrantFiled: November 20, 2020Date of Patent: February 14, 2023Assignee: Edwards Lifesciences CorporationInventors: Yaron Keidar, W. Vaso Adzich, Dan Rottenberg, Boaz Manash, Alon Nahshon
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Patent number: 11576667Abstract: Suture locking clamps for securing prostheses such as heart valves or annuloplasty rings with sutures and without using knots improve the ease of implantation. The clamps have opposed clamp halves separated by a slot opening to one side and surrounded by a biasing member such as one or more C-clip springs. Sutures pass laterally into the slot which is held open by a retention member positioned between the clamp halves. The locking clamp slides along the sutures into position, the tension of the sutures is adjusted, and the retention member removed to allow the biasing member to clamp the sutures between the clamp halves. A delivery tool used to deliver and deploy the locking clamps contains a number of clamps within a delivery tube in a stack and bonded together for safety and a common retention member. The tool has a longitudinal channel on one side for entry of sutures.Type: GrantFiled: April 27, 2020Date of Patent: February 14, 2023Assignee: Edwards Lifesciences CorporationInventors: Brian S. Conklin, Louis A. Campbell, Salvador Marquez, Donald E. Bobo, Jr.
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Patent number: 11571216Abstract: Aortic occlusion and embolic protection devices include radially expandable and collapsible proximal and distal end portions, such as annular self-expanding stents or frames, that are configured to radially expand within an aorta to secure the device within the aorta. The devices can also include a catheter extending axially between the distal end portion and the proximal end portion and a porous covering, or filter, positioned around the catheter and between the proximal end portion and the distal end portion and configured to filter emboli from blood flowing into upper-body arteries. The device can further include a one-way valve positioned at or adjacent to the distal end portion of the device and configured to restrict retrograde blood flow through the device toward the heart.Type: GrantFiled: May 28, 2020Date of Patent: February 7, 2023Assignee: Edwards Lifesciences CorporationInventors: Mark M. Dehdashtian, Teodoro S. Jimenez, Nathan Satter, Fabian Daniel Schroeder, Raffaele Mazzei, Jeff Kosmoski, Shahram Zamani, Adam J. Yestrepsky
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Patent number: 11571299Abstract: Disclosed prosthetic valves can comprise a sewing ring configured to secure the valve to an implantation site. Some disclosed valves comprise a resiliently collapsible frame having a neutral configuration and a collapsed deployment configuration. Some disclosed frames can self-expand to the neutral configuration when released from the collapsed deployment configuration. Collapsing a disclosed valve can provide convenient access to the sewing ring, such as for securing the valve to the implantation site, as well as for the insertion of the valve through relatively small surgical incisions.Type: GrantFiled: July 6, 2020Date of Patent: February 7, 2023Assignee: Edwards Lifesciences CorporationInventors: Hengchu Cao, Brian S. Conklin, Paul A. Schmidt, Grace Myong Kim, James A. Davidson, Hoa Trinh Tran, Kristy Luong Tam
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Patent number: 11559415Abstract: Described herein are radially self-expanding stents. The disclosed stents can be used to widen arteries and/or veins of a patient to counteract or combat narrowing of the arteries and/or veins associated with certain congenital diseases, such as aortic coarctation. As an example, the disclosed stents are configured to be placed at or near a narrowed portion of the aorta where the stent produces a radial outward force on the aorta. The radial force produced by the stent widens the aorta and causes the stent to expand with the aorta. The disclosed stents can be crimped to relatively small sizes for placement in small patients (e.g., less than about 10 kg in size) and can be configured to expand to widen the aorta and to accommodate growth in the patient.Type: GrantFiled: November 18, 2019Date of Patent: January 24, 2023Assignee: Edwards Lifesciences CorporationInventor: Nima V. Nia
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Patent number: 11559395Abstract: A prosthetic mitral valve has an interior stent and an exterior mesh surrounding the interior stent. The prosthetic mitral valve is released from a capsule and self-expands within a native mitral valve. The exterior wire mesh has a first portion with an enlarged diameter sized for placement above a mitral annulus and a second portion with a reduced diameter for contacting the mitral annulus. Capturing elements are provided on the interior stent. The capturing elements extend in a ventricular direction beyond the exterior wire mesh and then turn in an atrial direction for trapping native mitral leaflets against an outer surface of the wire mesh. A plurality of valve leaflets is provided within the interior stent for replacing the function of the native mitral valve.Type: GrantFiled: January 13, 2020Date of Patent: January 24, 2023Assignee: Edwards Lifesciences CorporationInventor: Konstantinos Spargias
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Patent number: 11561151Abstract: Systems, devices, and methods for leak testing surgical conduit grafts or valved conduits such as aortic-valved conduits with a pressurized gas such as air. Air is non-destructive and especially useful for leak testing conduits that have coatings or sealants that may be functionally impacted when exposed to fluids such as water or saline. Open ends of the conduit are clamped and sealed, and a pressurized gas introduced into an inner lumen thereof. A change in mass flow rate is measured to quantify the leakage. One end of a tubular conduit may be clamped to a fixed manifold, and the opposite end to a manifold slidably mounted to accommodate any conduit elongation when pressurized. The clamping and sealing structure may be pneumatic and/or mechanical, and complementary contoured clamp members may be used to seal a scalloped external sealing ring of an aortic conduit.Type: GrantFiled: July 19, 2021Date of Patent: January 24, 2023Assignee: Edwards Lifesciences CorporationInventors: Mark Van Nest, Alyssa E. Kornswiet, Jackie P. Lau
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Patent number: D977101Type: GrantFiled: November 15, 2019Date of Patent: January 31, 2023Assignee: Edwards Lifesciences CorporationInventors: Dustin P. Armer, Sergio Delgado, Michael D. Franklin, Eason Michael Abbott, Tram Ngoc Nguyen
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Patent number: D979061Type: GrantFiled: February 9, 2022Date of Patent: February 21, 2023Assignee: Edwards Lifesciences CorporationInventor: Louis A. Campbell
