Patents Assigned to Edwards Lifesciences Corporations
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Patent number: 11806234Abstract: A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising a plurality of circumferentially extending rows of angled struts, including first, second, and third rows of angled struts forming rows of diamond-shaped cells, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is disposed between the frame and the cusp edge portions, the skirt being sutured to selected struts of the frame along diagonal paths extending from an inflow end portion toward an outflow end portion. Each diagonal path along which the skirt is sutured to the frame extends along the first, second, and third rows of angled struts.Type: GrantFiled: April 13, 2022Date of Patent: November 7, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Nikolai Gurovich, Michael Bukin, Elena Sherman, Tamir S. Levi, Ziv Yohanan, Gil Senesh, Dikla Kersh, Alexey Tsypenyuk, Waina Michelle Chu, Alexander Barash
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Patent number: 11806001Abstract: Disclosed is a delivery device, kit, system, method, etc. for localized fusion of leaflets of a tissue valve, for example, a native heart valve, using an adhesive. The delivery device can have one or more capture features for capturing separate leaflets, for example, the anterior and posterior mitral leaflets. An applicator can be configured to apply a biocompatible adhesive between the captured leaflets, and one or more curing elements can be configured to cure the applied biocompatible adhesive. The kit can have the aforementioned delivery device, and the biocompatible adhesive used therewith. The method can include positioning the aforementioned delivery device adjacent the anterior and posterior mitral leaflets, capturing the mitral leaflets between the paddles of the delivery device, applying a biocompatible adhesive between the captured mitral leaflets via the applicator, and curing the applied biocompatible adhesive via the energy elements to locally fuse the mitral leaflets.Type: GrantFiled: April 16, 2020Date of Patent: November 7, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Hengchu Cao, Shih-Hwa Shen, Holly Kung Jung Hsu, Krystal Ya-Fong Lai
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Patent number: 11806232Abstract: A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. Interlocking members or flexible loops are included to limit expansion of the valve to one or two valve sizes, for example, with a 2-mm gap between each valve size. The valve may include an internal structural band with overlapped free ends having structure for limiting expansion, or external loops of suture may be added to the fabric covering which limits expansion.Type: GrantFiled: August 24, 2020Date of Patent: November 7, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Brian S. Conklin, Da-Yu Chang
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Patent number: 11801138Abstract: A method for delivering a prosthetic valve to a native annulus of a heart can include inserting a delivery apparatus into a patient's body, advancing the delivery apparatus to an implantation location within the native annulus, retracting a delivery sheath of the delivery apparatus relative to the prosthetic valve to expose the prosthetic valve from a distal end of the delivery sheath, and after the prosthetic valve is exposed from the delivery sheath, expanding the prosthetic valve from a radially compressed state to a radially expanded state by reducing axial tension on a first end and a second end of the prosthetic valve.Type: GrantFiled: March 3, 2020Date of Patent: October 31, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Arvin T. Chang, Yair A. Neumann, Gil Senesh, Hernan Altman, Scott Louis Pool, Hannah Gibson, Amanda Kristine Anderson White, Peter Phong Tran, Ly Th Phan
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Patent number: 11801132Abstract: A prosthetic heart valve can include a stent and a leaflet assembly mounted to the stent. The stent is formed by a plurality of struts and includes an inflow end and an outflow end. The stent is deformable from a radially compressed configuration to a radially expanded configuration. The plurality of struts forms a plurality of rows of cells. The plurality of rows of cells includes a row of inflow cells at the inflow end, a row of outflow cells at the outflow end, and a row of intermediate cells that follows the row of outflow cells towards the inflow end. Each inflow cell comprises an inflow free apex. Each outflow cell comprises an outflow free apex and extends along an axial direction of the stent up to an end of said row of intermediate cells that points towards the inflow end of the stent.Type: GrantFiled: June 16, 2022Date of Patent: October 31, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventor: Sergio Delgado
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Patent number: 11801133Abstract: Docking devices for docking a prosthetic valve at a native valve of a heart can include a coiled docking anchor and a retrieval suture. The docking device and retrieval suture can be configured for improved retention and retrieval of the docking device after deployment. The docking devices can have an end portion with a central axis. The retrieval suture can be connected to the end portion such that a line of force applied by applying tension to the retrieval suture is substantially aligned with the central axis.Type: GrantFiled: July 20, 2020Date of Patent: October 31, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Darshin S. Patel, Boaz Manash, Khen Perlmutter, Eyal Leiba, Yoav Rozen, Dinesh L. Sirimanne, Tri D. Tran, Jocelyn Chau, Noa Axelrod Manela, Zohar Kiblitski
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Patent number: 11793632Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.Type: GrantFiled: July 18, 2019Date of Patent: October 24, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Tamir S. Levi, Son V. Nguyen, Netanel Benichou, David Maimon, Ziv Yohanan, Nikolay Gurovich, Bella Felsen, Larisa Dadonkina, Ron Sharoni, Elena Sherman
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Patent number: 11793505Abstract: A first end of a wire is transluminally advanced to a location adjacent an atrium of a heart of a subject, while a second end of the wire remains disposed outside of the subject. From the location, the first end of the wire is penetrated through tissue into the atrium. A capture device is transluminally advanced into the atrium. Using the capture device, the first end of the wire is captured and pulled out of the subject. From the first end of the wire, a first anchor is tracked along the wire into the atrium, and is anchored to an annulus of a valve of the heart. A second anchor is advanced into the atrium, and is anchored to the annulus. Subsequently, the annulus is reshaped by applying tension between the first and second anchors.Type: GrantFiled: February 9, 2021Date of Patent: October 24, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Adam Groothuis, Steven D. Cahalane, Richard J. Morrill, John Alexander
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Patent number: 11793642Abstract: In one representative embodiment, an implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion. The prosthetic device can be movable between multiple configurations. The spacer body can be made from braided, self-expandable metallic thread. A delivery apparatus can have a first shaft and a second shaft, wherein movement of the first shaft relative to the second shaft moves the anchor portion relative to the spacer body.Type: GrantFiled: July 25, 2019Date of Patent: October 24, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Mark Chau, David M. Taylor, Alexander J. Siegel, Christopher J. Olson, Sergio Delgado, Alexander H. Cooper, Lauren R. Freschauf, Asher L. Metchik, Matthew T. Winston, Cristobal R. Hernandez, Emil Karapetian, Bao Khuu, Eric Robert Dixon
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Patent number: 11793631Abstract: An assistance system that can be used for prosthetic heart valve manufacturing or suturing procedures includes an automated fixture that can comprise an articulation arm and a target device holder. The target device holder can be positioned and oriented to reduce operator strain during a manufacturing or inspection process. The assistance system includes a user input device enabling the operator to move between positions to assist in such processes. The assistance system can also be trained by capturing sequences of position data corresponding to a manufacturing or inspection process.Type: GrantFiled: February 24, 2022Date of Patent: October 24, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Arthur I. Koral, James R. Cody, III, Ping-Yang Shih, Tiffany Diemtrinh Tran
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Patent number: 11786695Abstract: Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for a cardiovascular device, then return to a non-expanded state after the passage of the device. The sheath includes an elongated annular member through which the cardiovascular device and its delivery system pass. In an embodiment, the annular inner member can be formed by coextruding a first and second material. The first material includes a fold, and the second material radially spaces the different parts of the fold from each other during fabrication and provides support for maintaining the tubular structure. The second material is removed once the coextrusion process is complete.Type: GrantFiled: July 17, 2019Date of Patent: October 17, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Erik Bulman, Duy Nguyen, Kim D. Nguyen
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Patent number: 11786374Abstract: A testing apparatus is disclosed herein for testing properties of a prosthetic device. The testing apparatus may comprise a dual-drive pulsatile flow tester with the ability to determine coaptation of valve leaflets of a prosthetic device. The testing apparatus may be able to test prosthetic heart valves and reproduce physiological conditions of a prosthetic heart valve.Type: GrantFiled: January 22, 2021Date of Patent: October 17, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Salvador Marquez, Lynn T. Dang, Javier A. Sanguinetti, Emily Cheng Zhou, Gary Alan Breitbach
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Patent number: 11786364Abstract: A delivery apparatus for a medical device implant can include an outer catheter and a flexible delivery catheter. The outer catheter can have an axially extending shaft and a first lumen extending co-axially through the axially extending shaft. The flexible delivery catheter can have an elongate shaft having a flexible section extending along a distal portion of the elongate shaft, and the flexible section of the elongate shaft can be positioned or adjusted between a first, delivery configuration and a second, activated configuration. The delivery catheter can have a pull wire extending co-axially through a second lumen axially extending through the elongate shaft. A distal end of the pull wire can be fixedly secured or attached to the distal end of the elongate shaft.Type: GrantFiled: August 25, 2020Date of Patent: October 17, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: David Maimon, Hernan Altman
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Publication number: 20230320847Abstract: A prosthetic heart valve assembly includes a self-expandable stent having a flared upper portion, a lower portion, and an intermediate portion extending from the upper portion to the lower portion. The stent includes upwardly bent hooks extending from an outer surface of the stent, which are adapted to engage native leaflet tissue. The stent further includes an elongate anchoring member extending from the lower portion of the stent, which is adapted to be secured to a ventricle wall via a prong portion. When deployed within the native heart valve, the flared upper portion contacts a supra-annular surface of the native heart valve for preventing downward migration of the prosthetic heart valve assembly toward the ventricle and the upwardly bent hooks and the elongate anchoring member prevent upward migration of the prosthetic heart valve assembly toward an atrium.Type: ApplicationFiled: June 13, 2023Publication date: October 12, 2023Applicant: EDWARDS LIFESCIENCES CORPORATIONInventors: Stanton J. Rowe, Mark Chau, Son V. Nguyen
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Patent number: 11779728Abstract: A system for introducing a delivery apparatus into a patient's vasculature. The system may include a sheath having a lumen and configured to be inserted into the patient's vasculature. An introducer has a channel for receiving a guide wire and is configured to be positioned within the lumen of the sheath. A plug is coupled to the introducer and is configured to move from a first position in which the plug has a first diameter to a second position in which the plug has a second diameter that is greater than the first diameter and greater than the interior diameter of the sheath, the plug being configured to slide within the lumen in a direction from the distal end of the sheath towards the proximal end of the sheath to expand the sheath in the direction radially outward from the lumen.Type: GrantFiled: November 21, 2019Date of Patent: October 10, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Tung T. Le, Sonny Tran
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Patent number: 11779460Abstract: A prosthetic implant delivery assembly includes a prosthetic implant including an expandable stent and a catheter for delivering the prosthetic implant. The expandable stent includes apices circumferentially-spaced apart relative to each other. At least some of the apices include an aperture disposed therein. The catheter includes arms disposed at an end of a shaft, and the arms are moveable between a radially compressed state and a radially expanded state via a sheath. The arms each include a hook portion for releasably engaging the apertures of the apices. The arms are configured to move from the radially compressed state to the radially expanded state when the plurality arms is exposed from within the sheath such that the hook portion disengages from the apices of the prosthetic implant and releases the expandable stent from the catheter.Type: GrantFiled: June 14, 2021Date of Patent: October 10, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventor: John J. Desrosiers
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Patent number: 11775613Abstract: Methods of quickly and easily implanting a quick-connect heart valve prosthesis during a surgical procedure are provided. The heart valve may include a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable frame, thereby enabling attachment to the annulus without sutures. A system and method for deployment includes an integrated handle shaft and balloon catheter. A safety member disposed between the balloon catheter and handle shaft prevents premature catheter advancement prior to heart valve placement at the annulus, and also may prevent premature balloon inflation prior to full catheter advancement.Type: GrantFiled: December 14, 2021Date of Patent: October 3, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Andrew Phung, August R. Yambao, Faisal Kalam, William C. Brunnett, Rafael Pintor, Michael J. Scott
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Patent number: 11766330Abstract: An implantable prosthetic device has a coaption element and at least one anchor. The coaption element is configured to be positioned within the native heart valve orifice to help fill a space where the native valve is regurgitant and form a more effective seal. The coaption element can have a structure that is impervious to blood. The coaption element can be connected to leaflets of the native valve by the anchor.Type: GrantFiled: April 13, 2020Date of Patent: September 26, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Alex Philip McCann, Grant Matthew Stearns, Eric Robert Dixon, Yoon Hee Kwon, Michael J. Popp, Sergio Delgado, Lauren R. Freschauf, Rachel Ann Cooney, Rachel Liat David Foreman
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Patent number: 11759200Abstract: Some disclosed suture securement devices comprise a flat, thin, generally planar body that has one or more suture engagement slots extending into the body from a perimeter inlet for receiving sutures laterally into the device. The slots can be resiliently widened to receive a suture and then released to clamp onto the suture. Some embodiments include two or more such suture engagement slots that independently receive and secure different sutures. Some embodiments include one or more locking tabs that have a closed position that retains the slots against widening and blocks the inlet to the slot. In some embodiment two or more slots are position next to each other on the same side of the device, while in other embodiments slots are positioned on opposite sides of the device. Other types of suture securement devices are also disclosed.Type: GrantFiled: November 11, 2019Date of Patent: September 19, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Manouchehr A. Miraki, Hengchu Cao, Ralph Schneider
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Patent number: 11759226Abstract: The invention is a device, system, and method for repairing heart valve function, which may include bisecting native valve leaflets for improved deployment of a prosthetic heart valve in the native valve annulus. The invention may include a catheter having a cutting element shaft with a cutting element configured to puncture a valve leaflet and/or make a controlled cut through the leaflet. The device may have an extendable foot configured to be positioned on an opposite side of the valve leaflet from the cutting element shaft. The device may include magnets to guide the cutting element and/or cutting element shaft in proper alignment with the extendable foot and to hold the elements in place during leaflet bisection.Type: GrantFiled: July 28, 2020Date of Patent: September 19, 2023Assignee: EDWARDS LIFESCIENCES CORPORATIONInventors: Gregory Bak-Boychuk, Ming H. Wu