Abstract: A hand-up initiating and responding method and interactive system in a multi-party video activity are disclosed. The hand-up initiating method in a multi-party video activity includes: step 1) pressing a hand-up button, sending a hand-up message, and updating a hand-up status in a local video window and hand-up statuses in a local roster; step 2) releasing the hand-up button, and starting countdown; step 3) sending a hand-up cancellation message and updating the hand-up status in the local video window and the hand-up statuses in the local roster at the end of the countdown; and step 4) if the hand-up button is pressed again within the countdown time, skipping to step 2) without sending a hand-up message. The present invention provides a special interactive mode, in which when a participant raises a question, an initiator can perceive in real time and respond in time.