Patents Assigned to Egis Gyogyszergyar
  • Crystalline pharmaceutically active ingredients
    Patent number: 9321733
    Abstract: The present invention is related to crystalline forms of rosuvastatin zinc (2:1) salt. The polymorphs are suitable for use as pharmaceutically active ingredients in the treatment of the diseases of the lipid metabolism including hypercholesterolemia, hyperlipidemia, dyslipidemia or atherosclerosis.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: April 26, 2016
    Assignee: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Imre Markovits, Ferenc Jurak, Gyorgyi Kovanyine Lax, Csaba Hamori, Balazs Havasi, Eva Sipos, Balazs Volk, Zsolt Runge, Krisztina Fodorne Kocsmar, Gyula Lukacs, Katalin Kataine Fadgyas, Monika Mezovari
  • Pharmaceutical intermediates and process for the preparation thereof
    Patent number: 9260421
    Abstract: The present invention relates to a process for the preparation of dabigatran etexilate of the formula or pharmaceutically accepted salts thereof.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: February 16, 2016
    Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Imre Kiraly, Tibor Szabo, Gyula Simig, Balazs Volk, Laszlo Szlavik, Jozsef Barkoczy, Gyorgy Ruzsics, Gyula Lukacs, Laszlo Pongo, Andras Boza, Maria Tothne Lauritz, Maria Kovacs
  • Rosuvastatin zinc salt
    Patent number: 9174945
    Abstract: The present invention is related to rosuvastatin zinc salt of the Formula (I), process for preparation thereof and medicinal products containing said salt. Rosuvastatin zinc salt according to the present invention is prepared by reacting rosuvastatin with a zinc alcoholate, zinc enolate or an inorganic or organic zinc salt and isolating the thus obtained rosuvastatin zinc salt (2:1).
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: November 3, 2015
    Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Pal Vago, Gyula Simig, Gyoergy Clementis, Peter Toempe, Sandorne Tapai
  • Process for preparing pharmaceutical compounds and intermediate compounds
    Patent number: 9169265
    Abstract: The object of the present invention is a process for preparing the 2-acetoxi-5-(2-fluor-?-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine (prasugrel) of the formula (I). The process starts from crystalline 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI). Further objects of the present invention are two novel crystalline forms of 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI) and the use thereof for preparing the compound of the formula (V) and process preparing thereof.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: October 27, 2015
    Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Márta Porcs-Makkay, Balázs Volk, Tamás Gregor, József Barkóczy, Tibor Mezei, Judit Broda, Bálint Nyulasi, György Ruzsics, Enikö Molnár, József Debreczeni, Kálmán Nagy, Angéla Pandur, Zsuzsanna Szent-Királlyi
  • Method for the preparation of high-purity pharmaceutical intermediates
    Patent number: 9133132
    Abstract: The present invention is related to intermediates useful in the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid and polymorphs of said intermediates, methods for preparation thereof and use thereof.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: September 15, 2015
    Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Gyorgyi Kovanyine Lax, Gyula Simig, Balazs Volk, Ferenc Lorant Bartha, Gyorgy Krasznai, Gyorgy Ruzsics, Eva Sipos, Kalman Nagy, Gyorgy Morovjan, Jozsef Barkoczy, Adrienn Keszthelyi, Janos Imre, Gabor Bagyinszki
  • Method for preparing rosuvastatin salts
    Patent number: 9040696
    Abstract: The present invention is related to methods for the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S,6E)-dihydroxy-hept-6-enoic acid, intermediates thereof and methods for producing said intermediates.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: May 26, 2015
    Assignee: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Marta Porcs-Makkay, Ferenc Lorant Bartha, Gyorgy Krasznai, Balazs Volk, Gyorgy Ruzsics, Laszlo Pongo, Gyula Lukacs, Tibor Szabo, Jozsef Barkoczy, Jozsef Debreczeni, Adrienn Keszthelyi, Angela Pandur, Eniko Molnar, Matyas Milen, Maria Tothne Lauritz
  • Crystalline form I rosuvastatin zinc salt
    Patent number: 9023838
    Abstract: The present invention relates to crystalline Form I rosuvastatin zinc (2:1) salt, method of preparation thereof and use thereof as pharmaceutically active ingredient for the treatment of diseases related to lipid metabolism including hyperlipoproteinemia, hypercholesteremia, dyslipidemia and atherosclerosis.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: May 5, 2015
    Assignee: Egis Gyogyszergyar Nyilvanosan Muekoedoe
    Inventors: Ferenc Bartha, Gyoergyi Kovanyine Lax, Balazs Volk, Jozsef Barkoczy, Gyoergy Morovjan, Gyoergy Krasznai, Kalman Nagy, Gyula Simig, Gyoergy Ruzsics, Gyoergy Clementis, Imre Kapui, Peter Slegel, Adrienn Keszthelyi, Zsuzsanna Szent-Kirallyi, Valeria Hoffmanne Fekete, Janos Imre
  • PHARMACEUTICAL FORMULATION HAVING IMPROVED STABILITY
    Publication number: 20150094345
    Abstract: The present invention is related to a pharmaceutical formulation containing ramipril with improved stability, which comprises ramipril and a desintegrant directly granulated with a binder.
    Type: Application
    Filed: February 17, 2012
    Publication date: April 2, 2015
    Applicant: EGIS GYOGYSZERGYAR ZRT.
    Inventors: Andras Feher, Zsolt Zsigmond, György Újfalussy, Péter Tonkanagy, György Morovjan
  • Stabilized pharmaceutical composition
    Patent number: 8968780
    Abstract: The invention relates to stabilized pharmaceutical composition comprising pregabalin and a disaccharide or higher polyol as stabilizer and optionally a conventional pharmaceutically acceptable carrier. The stabilized pharmaceutical composition according to the invention is useful in the treatment of a number of diseases such as epilepsy, Alzheimer's disease or Parkinson's disease.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: March 3, 2015
    Assignee: Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag
    Inventors: Kamala S. Yadav, Amita P. Surana, Sanjivani A. Kulkarni, Rashmi R. Prasade
  • Granulating process and thus prepared granulate
    Patent number: 8927021
    Abstract: The present invention relates to a process for manufacturing microcrystalline ezetimibe containing granulate, wherein a) ezetimibe is dissolved; b) the dissolved ezetimibe is precipitated with water, which if necessary contains pharmaceutical excipients, preferably lauryl-sulfate derivatives, and c) granulates are formed from the obtained suspension by spraying the suspension onto pharmaceutical excipients. A further aspect of the present invention is the granulate obtained by the present process and the pharmaceutical composition containing such granulate.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: January 6, 2015
    Assignee: Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszventarsasag
    Inventors: Zoltan Toelgyesi, Zsolt Zsigmond, Gyoergy Ujfalussy, Magdolna Leventiszne Huszar, Peter Tonka-Nagy, Monika Agyagos
  • Method for purifying diatomaceous earth
    Patent number: 8883860
    Abstract: A method for purifying diatomaceous earth, whose natural colloidal structure is retained, which includes preparing a suspension of diatomaceous earth in a liquid wherein diatomaceous earth is insoluble, separating diatomaceous earth from the suspension, treating diatomaceous earth with an inorganic or organic acid, heat-treating the thus obtained product at a temperature not higher than 300° C., subjecting the product obtained to oxidative treatment and drying the purified product.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: November 11, 2014
    Assignees: Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag, ONP Holdings SE
    Inventors: Endre Mikulásik, Tamás Spaits, Kálmán Nagy, Gyula Lukács, Imre Markovits, Krisztina Fodorné Kocsmár, Livia Gregorné Boros, Tamás Mórász, László Szlávik, Máté Hudák, Gyöngyi Heréb, Réka Eszter Puskás, Zoltán Varga, Imre Kapui, György Clementis, Gábor Attila Bacher, Beatrix Bánkövi, Gitta Kiss, Ottó Albrecht
  • Dihydro-oxazolobenzodiazepinone compounds, a process for there preparation and pharmaceutical compositions containing them
    Patent number: 8778932
    Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or an alkyl group; R2 represents an alkyl group; R3 represents an aryl or heteroaryl group. Medicinal products containing the same which are useful in the treatment or prevention of psychiatric and neurological disorders characterized by cognitive deficits.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: July 15, 2014
    Assignees: Les Laboratoires Servier, Egis Gyogyszergyar Nyrt
    Inventors: István Ling, József Barkóczy, Ferenc Antoni, István Gascályi, György Lévay, Michael Spedding, László Hársing
  • PHARMACEUTICAL INTERMEDIATES AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20140155614
    Abstract: The present invention relates to a process for the preparation of dabigatran etexilate of the formula or pharmaceutically accepted salts thereof.
    Type: Application
    Filed: May 10, 2012
    Publication date: June 5, 2014
    Applicant: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Imre Kiraly, Tibor Szabo, Gyula Simig, Balazs Volk, Laszlo Szlavik, Jozsef Barkoczy, Gyorgy Ruzsics, Gyula Lukacs, Laszlo Pongo, Andras Boza, Maria Tothne Lauritz, Maria Kovacs
  • PROCESS FOR THE PREPARATION OF A RIVAROXABAN AND INTERMEDIATES FORMED IN SAID PROCESS
    Publication number: 20140142303
    Abstract: The invention relates to a process for the preparation of 5-chloro-N-({(5-S)-2-oxo3-[4-(3-oxo-morj)holine-4-yl)-phenyl]-1,3-oxazolidine-5-yl}-methyl) thiophen-2-carboxamide having the INN rivaroxaban. The process is characterized by the reactions according to claim 1. The invention also relates to intermediates formed in the above process.
    Type: Application
    Filed: May 4, 2012
    Publication date: May 22, 2014
    Applicant: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Eva Sipos, Gyorgyi Kovanyine Lax, Balazs Havasi, Balazs Volk, Gyorgy Krasznai, Gyorgy Ruzsics, Jozsef Barkoczy, Maria Tothne Lauritz, Gyula Lukacs, Andras Boza, Laszlo Jozsef Hegedus, Maria Julia Taborine Toth, Eva Pecsi
  • METHOD FOR THE PREPARATION OF HIGH-PURITY PHARMACEUTICAL INTERMEDIATES
    Publication number: 20130338360
    Abstract: The present invention is related to intermediates useful in the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid and polymorphs of said intermediates, methods for preparation thereof and use thereof.
    Type: Application
    Filed: November 29, 2011
    Publication date: December 19, 2013
    Applicant: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytars
    Inventors: Gyorgyi Kovanyine Lax, Gyula Simig, Balazs Volk, Ferenc Lorant Bartha, Gyorgy Krasznai, Gyorgy Ruzsics, Eva Sipos, Kalman Nagy, Gyorgy Morovjan, Jozsef Barkoczy, Adrienn Keszthelyi, Janos Imre, Gabor Bagyinszki
  • CRYSTALLINE PHARMACEUTICALLY ACTIVE INGREDIENTS
    Publication number: 20130296353
    Abstract: The present invention is related to crystalline forms of rosuvastatin zinc (2:1) salt. The polymorphs are suitable for use as pharmaceutically active ingredients in the treatment of the diseases of the lipid metabolism including hypercholesterolemia, hyperlipidemia, dyslipidemia or atherosclerosis.
    Type: Application
    Filed: November 16, 2011
    Publication date: November 7, 2013
    Applicant: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytar- sasag
    Inventors: Imre Markovits, Ferenc Jurak, Gyorgyi Kovanyine Lax, Csaba Hamori, Balazs Havasi, Eva Sipos, Balazs Volk, Zsolt Runge, Krisztina Fodorne Kocsmar, Gyula Lukacs, Katalin Kataine Fadgyas, Monika Mezovari
  • METHOD FOR PREPARING ROSUVASTATIN SALTS
    Publication number: 20130281694
    Abstract: The present invention is related to methods for the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S,6E)-dihydroxy-hept-6-enoic acid, intermediates thereof and methods for producing said intermediates.
    Type: Application
    Filed: November 29, 2011
    Publication date: October 24, 2013
    Applicant: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENY-TARSASAG
    Inventors: Marta Porcs-Makkay, Ferenc Lorant Bartha, Gyorgy Krasznai, Balazs Volk, Gyorgy Ruzsics, Laszlo Pongo, Gyula Lukacs, Tibor Szabo, Jozsef Barkoczy, Jozsef Debreczeni, Adrienn Keszthelyi, Angela Pandur, Eniko Molnar, Matyas Milen, Maria Tothne Lauritz
  • METHOD FOR PREPARATION OF AN EXCIPIENT SUITABLE FOR PHARMACEUTICAL USE
    Publication number: 20130225695
    Abstract: The present invention is related to a method for purifying diatomaceous earth wherein the natural colloidal structure of the material is retained, which comprises preparing a suspension of diatomaceous earth in a liquid wherein diatomaceous earth is insoluble, separating diatomaceous earth from the suspension, treating diatomaceous earth with an inorganic or organic acid, heat-treating the thus obtained product at a temperature not higher than 300° C., subjecting the product obtained to oxidative treatment and drying the purified product. The invention also relates to a product obtainable by the above-mentioned method.
    Type: Application
    Filed: October 12, 2011
    Publication date: August 29, 2013
    Applicants: ONP HOLDINGS SE, EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Endre Mikulásik, Tamás Spaits, Kálmán Nagy, Gyula Lukács, Imre Markovits, Krisztina Fodorné Kocsmár, Livia Gregorné Boros, Tamás Mórász, László Szlávik, Máté Hudák, Gyöngyi Heréb, Réka Eszter Puskás, Zoltán Varga, Imre Kapui, György Clementis, Gábor Attila Bacher, Beatrix Bánkövi, Gitta Kiss, Ottó Albrecht
  • Process for the preparation of rosuvastatin salts
    Patent number: 8507513
    Abstract: The present invention relates to a new process for the preparation of rosuvastatin [7-[4-(4-Fluorophenyl)-6-isopropyl-2-(methanesulphonyl-methyl-amino)-pyrimidin-5-yl]-(3R,51S)-dihydroxy-hept-6-enoic acid] of the formula (I) salts formed with bivalent cations, preferably with calcium or zinc ions, characterized in that rosuvastatin tert.-butylammonium salt is reacted with the appropriate bivalent cation, preferably with calcium or zinc ions in a mixture of a water immiscible or slightly miscible organic solvent and water and the formed salt is isolated.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: August 13, 2013
    Assignee: Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag
    Inventors: Gyoergyi Kovanyine Lax, Eva Sipos, Jozsef Barkoczy, Balazs Volk, Gyula Simig, Ferenc Bartha, Gyoergy Ruzsics, Adrienn Karasz, Imre Kiraly, Kalman Nagy
  • USE OF DIATOMACEOUS EARTH IN THE PHARMACEUTICAL INDUSTRY
    Publication number: 20130149380
    Abstract: The present invention is related to solid pharmaceutical preparations containing diatomaceous earth (diatomite) or a natural mineral mixture containing diatomaceous earth as filler besides the active ingredient and optional other auxiliary agents. A further object of the invention is a method for manufacturing such pharmaceutical preparations.
    Type: Application
    Filed: May 27, 2011
    Publication date: June 13, 2013
    Applicants: ONP HOLDINGS SE, EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Endre Mikulásik, Ottó Albrecht