Abstract: Provided are a CAR library used to screen scFvs that can be functional in CAR-T cells, and an scFv manufacturing method in which the CAR library is used. A chimeric antigen receptor (CAR) library of the present invention includes nucleic acids coding for first CARs. Each of the first CARs includes a first antigen-binding domain, a first transmembrane domain, and a first intracellular signaling domain. The first antigen-binding domain includes a first single-chain antibody (scFv) to be screened for the ability to bind to a target antigen. The first scFv includes a first heavy-chain variable region and a first light-chain variable region. The first heavy-chain variable region and the first light-chain variable region meet a predetermined condition.

Abstract: A bone conduction hearing-aid unit that is entirely embedded under a scalp. The bone conduction hearing-aid unit includes a vibration generating device configured to generate vibration, and an anchor fixed to a skull and configured to transmit the vibration to the skull. The vibration generating device is detachably fixed to the anchor.

Abstract: A bone conduction hearing-aid unit embedded under a scalp. The bone conduction hearing-aid unit includes a vibration generator configured to generate vibration, and an anchor. A magnetic field frequency is applied to the vibration generator from the outside of the scalp to generate vibration. The vibration is transmitted to a skull via the anchor.

Abstract: A magnetic memory device includes a first magnetic memory device, a second magnetic memory device, a pulse power supplying current pulses to the first and second magnetic memory devices; and a switch configured to selectively connect the pulse power to one of the first and second magnetic memory devices. A resistance value of an MTJ device composed of the first fixed layer, the first non-magnetic layer, and the free layer is different from a resistance value of a MTJ device composed of the second fixed layer, the second non-magnetic layer, and the free layer.

Abstract: A magnetic memory device includes a first magnetic memory device, a second magnetic memory device, a pulse power supplying current pulses to the first and second magnetic memory devices; and a switch configured to selectively connect the pulse power to one of the first and second magnetic memory devices. A resistance value of an MTJ device composed of the first fixed layer, the first non-magnetic layer, and the free layer is different from a resistance value of a MTJ device composed of the second fixed layer, the second non-magnetic layer, and the free layer.

Abstract: The present invention relates to a polypeptide consisting of an amino acid sequence selected from: (a) the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8, (b) an amino acid sequence that differs from the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8 by substitution, deletion, addition, or insertion of 1 to 10, preferably 1-5, more preferably 1, 2 or 3 amino acids, and (c) an amino acid sequence that has at least 95%, preferably 97%, more preferably 99% sequence identity with the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 8, and a malaria vaccine comprising the polypeptide, for example.

Abstract: Provided is a method for introducing a selected molecule, including: an inhibitor treatment step of allowing a target cell or a target tissue to internalizing an inhibitor of vesicular transport or lysosomal membrane fusion; and an introduction step of contacting an introduction liquid containing a selected molecule with the target cell or the target tissue to introduce the selected molecule into the target cell or the target tissue.

Abstract: The present invention provides a photosynthesis rate measurement system capable of measuring carbon dioxide concentration in order to calculate the photosynthesis rate of plants with a simple configuration. The present invention is a photosynthesis rate measurement system, including a covering portion covering target plants, a sensor housing, and a sensor alternately measuring carbon dioxide concentrations inside and outside the covering portion. The sensor is provided in the sensor housing, and an air stirring portion to improve the sensor's response is equipped in the sensor housing.

Abstract: There is provided a ligament reconstruction type artificial knee joint that can exert a function of an anterior cruciate ligament in an original knee joint. In an artificial knee joint 1 used in a total knee replacement, the artificial knee joint 1 includes: a femur member 10 mounted on a femur distal end DT; a tibia member 20 mounted on a tibia proximal end PE; and an artificial ligament 30 coupling the tibia member 20 and the femur member 10 together. One end of the artificial ligament 30 is coupled to a position where once an anterior cruciate ligament ACL exists in a knee replaced for the artificial knee joint 1 on an inside of a lateral condyle of the femur member 10, and the other end of the artificial ligament 30 is coupled to a position where once the anterior cruciate ligament ACL exists in the knee replaced for the artificial knee joint 1 on an upper side of the tibia member 20.

Abstract: An analysis method is provided that ensures objective and quantitative analysis for analyzing time-series images.

Abstract: There is provided a ligament reconstruction type artificial knee joint that can exert a function of an anterior cruciate ligament in an original knee joint. In an artificial knee joint 1 used in a total knee replacement, the artificial knee joint 1 includes: a femur member 10 mounted on a femur distal end DT; a tibia member 20 mounted on a tibia proximal end PE; and an artificial ligament 30 coupling the tibia member 20 and the femur member 10 together. One end of the artificial ligament 30 is coupled to a position where once an anterior cruciate ligament ACL exists in a knee replaced for the artificial knee joint 1 on an inside of a lateral condyle of the femur member 10, and the other end of the artificial ligament 30 is coupled to a position where once the anterior cruciate ligament ACL exists in the knee replaced for the artificial knee joint 1 on an upper side of the tibia member 20.

Abstract: The present invention provides an artificial knee joint that can reconstruct an anterior cruciate ligament in a state close to an original function. An artificial knee joint (1) that is used in a total knee replacement includes a femur member (10) and a tibia member (20). The tibia member (20) has a ligament insertion hole (20h) which pierces the tibia member (20) and which is formed at a position where once an anterior cruciate ligament (ACL) exists in a knee replaced for the artificial knee joint (1). Therefore, a ligament can be provided such that a distal end (DT) of a femur (F) and a proximal end (PE) of a tibia (T) are joined to each other by passing the ligament through the ligament insertion hole (20h), which allows the anterior cruciate ligament (ACL) to be reconstructed so as to be in the substantially same state as a knee replaced for the artificial knee joint (1).

Abstract: Disclosed herein is a functional material having the function of detecting a predetermined substance or the like present in a sample with high accuracy even when the amount of the sample is small, and a method for producing the functional material. The functional material includes a channel part 10 that allows a liquid to pass therethrough, and the channel part 10 is made of a water-permeable material 11 containing a water-impermeable material 12. The water-impermeable material 12 is placed between pieces of the water-permeable material 11, and therefore voids 10h can be formed between the water-impermeable material 12 and the water-permeable material 11. That is, a network of the voids 10h can be formed in the channel part 10. A liquid sample supplied to the channel part 10 is allowed to move while being allowed to penetrate into the voids 10h.

Abstract: Provided are a detection method for a myriad of proteins involved in an autoimmune disease with high sensitivity and high efficiency, and an analysis method for data resulting from the detection method. In order to construct the detection method and analysis method, there is provided means for comprehensively analyzing the proteins involved in an autoimmune disease by bringing a mammal-derived protein expressed in a cell-free protein synthesis system into contact with a sample derived from a patient with an autoimmune disease to detect autoantibody production, and subjecting the detected data to statistical analysis processing, and further, gene ontology analysis and/or pathway analysis.

Abstract: The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human specimen, an anti-malaria measure support system, and a malaria infection-prevention/treatment system, which can contribute to practical diagnosis in a malaria endemic area. According to the present invention, using a genus-specific primer set that can detect four Plasmodium parasites that infect humans at a time, and the primer sets each specific to each of four species of Plasmodium parasites (P. falciparum, P. vivax, P. malariae, and P. ovale), the presence or absence of infection with these parasites can be detected/identified easily and rapidly.

Abstract: Provided is a composition that contains an antisense oligonucleotide to a micro RNA and is capable of inhibiting the growth of cancer cells. The present invention, as one aspect, relates to a composition for suppressing the growth of human cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-133a, hsa-miR-133b, hsa-miR-346 and hsa-miR-361-3p. The present invention, as another aspect, relates to a composition for suppressing the growth of human head/neck cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-92a, hsa-miR-133a, hsa-miR-133b, hsa-miR-139-5p, hsa-miR-197, hsa-miR-328, hsa-miR-346, hsa-miR-361-3p, hsa-miR-605, hsa-miR-766, hsa-miR-1228, hsa-miR-1252, hsa-miR-1260 and hsa-miR-1271.

Abstract: Provided are a nitric oxide detection element capable of detecting NO gas contained in a mixed gas at a high speed even when the amount thereof is a super trace amount of ten and several parts per billion; and a process for producing the element. In a nitric oxide detection element having a substrate 12 and a sensing film 11 formed on a surface of the substrate, the sensing film is composed of nitric oxide sensing particles and a polymer adhesive. The nitric oxide sensing particles are produced by adsorbing a dye having a porphyrin skeleton and having, as a central metal, divalent cobalt onto surfaces of inorganic particles.

Abstract: An objective of the present invention is to provide a decoder, a perpendicular magnetic recording and reproducing device, a receiving device, and a decoding method that are used for performing decoding resistant to burst errors such as a pole-erase phenomenon, where the burst errors do not have amplitude fluctuation, without the addition of a special code (redundant code) for detecting burst errors. The present invention is a decoder, a perpendicular magnetic recording and reproducing device, a receiving device, and a decoding method that perform a decoding process on an encoded data signal, wherein a parity check is performed on the encoded data signal that is encoded with a low density parity check code to output burst information.

Abstract: Provided are a method for analyzing metastasis of head and neck cancer to a cervical lymph node, and a tumor marker for head and neck cancer used therein. Specifically, provided is a method for analyzing metastasis of head and neck cancer to a cervical lymph node, involving: measuring an expression level of at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing in a cervical lymph node sample; and comparing the aforementioned expression level with a reference value. Also provided is a tumor marker for head and neck cancer used in the aforementioned method for analyzing cervical lymph node metastasis, including at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing, and/or an expression product of the aforementioned gene and/or an expression level thereof.

Abstract: This invention is to provide a method for the production of diamond at a high rate and in a high efficiency using in-liquid plasma. The present invention is a method for the production of diamond using electromagnetic waves irradiated to a liquid containing carbon, hydrogen and oxygen in which the ratio of hydrogen atoms to the sum of carbon atoms and hydrogen atoms is from 0.75 to 0.82 and the ratio of carbon atoms to the sum of carbon atoms and oxygen atoms is from 0.47 to 0.58 so as to generate plasma in the liquid.