Abstract: Systems and methods for cooling the contents within a portable case, such as a transit case, using a thermoelectric air conditioner. Thermoelectric air conditioners are used with, and mounted on or in, a transit case for maintaining a desired air temperature within the transit case. In one embodiment, the thermoelectric air conditioner can be incorporated, concealed within the housing and/or cover of the transit case. In this embodiment, the thermoelectric air conditioner is protected by the design of the case, the mounting arrangement, the shock-mounted frame, etc. Alternatively, the thermoelectric air conditioner is mounted partially internal and partially external to the transit case. In another embodiment, the thermoelectric air conditioner is mounted external to the transit case.