Abstract: A process for continuous purification of a multi-component mixture by means of individual chromatographic columns though which the mixture is fed by means of at least one solvent. The multi-component mixture comprises at least light impurities, an intermediate product, and heavy impurities. The columns are grouped into at least four sections (?, ?, ?, ?) and the fourth section contains three sub-sections (?r, ?f, ?g). The process operates, alternatingly, in a batch-mode position and in an interconnected-mode position. After or within a switch time, the columns are moved in their function in a counter direction to the general direction of flow of the solvent. The combination of batch chromatography with elements of simulated moving bed techniques, or rather, countercurrent-principles, allows for the separation of a true multi-component mixture, even if one of the products is only present in a small amount, comparatively.

Abstract: Electrochemical biosensor arrays and systems, as well as methods of making the electrochemical biosensor arrays and systems, are described herein. The electrochemical biosensor systems can be used with CMOS detection circuits that have a plurality of chemical detection and/or actuation channels or sites. The biosensor systems generally include a first inert conducting electrode disposed on a first portion of a CMOS detection circuit and a polymeric layer adjacent the first inert conducting electrode. The biosensor systems can also include a capture biomolecule bound to the polymeric layer. The biosensor system can also include the CMOS detection and/or actuation circuit having a plurality of channels.

Abstract: B-tris(silylvinyl)borazine is pyrolysed as a borazine precursor for the production of a B/N/C/Si ceramic. A high-temperature ceramic is obtained by means of a further pyrolysis at higher temperatures after a pre-pyrolysis, which is of high purity and essentially free of pores. The ceramic furthermore contains essentially no oxygen and is particularly suitable as a coating material and for the production of heating elements.

Abstract: The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.

Abstract: The present invention relates to recombinant N-glycosylated proteins, comprising one or more introduced N-glycosylated optimized amino acid sequence(s), nucleic acids encoding these proteins as well as corresponding vectors and host cells. In addition, the present invention is directed to the use of said proteins, nucleic acids, vectors and host cells for preparing medicaments. Furthermore, the present invention provides methods for producing said proteins.

Abstract: The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.

Abstract: A method for generating a 3D representation of a dynamically changing 3D scene, which includes the steps of: acquiring at least two synchronised video streams (120) from at least two cameras located at different locations and observing the same 3D scene (102); determining camera parameters, which comprise the orientation and zoom setting, for the at least two cameras (103); tracking the movement of objects (310a,b, 312a,b; 330a,b, 331 a,b, 332a,b; 410a,b, 411a,b; 430a,b, 431a,b; 420a,b, 421 a,b) in the at least two video streams (104); determining the identity of the objects in the at least two video streams (105); determining the 3D position of the objects by combining the information from the at least two video streams (106); wherein the step of tracking (104) the movement of objects in the at least two video streams uses position information derived from the 3D position of the objects in one or more earlier instants in time.

Abstract: The present invention provides polymer gel-processing techniques and polymer articles of high modulus.

Abstract: A sheet-like substrate (34) is coated with at least one thin film (36?) composed of at least one porous ceramic layer (S?1, S?2, S?3, . . . ). A solution or a suspension of an organic and/or inorganic metal composite as starting material (14) is admixed with a mixed-in, insoluble pore former (18) and the mixture (22) is sprayed on as layer (S?1, S?2, S?3, . . . ) of a thin film (36). The pore former (18) is at least partly thermally decomposed and/or burnt out to form an at least partly open-pored structure. The process is particularly suitable for producing miniaturized devices such as fuel cells and gas sensors.

Abstract: Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffusion. As demonstrated by the examples, one method is to bind heparin to the matrix by either covalent or non-covalent methods, to form a heparin-matrix. The heparin then non-covalently binds heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein can be constructed which contains a crosslinking region such as a factor XIIIa substrate and the native protein sequence. Incorporation of degradable linkages between the matrix and the bioactive factors can be particularly useful when long-term drug delivery is desired, for example in the case of nerve regeneration, where it is desirable to vary the rate of drug release spatially as a function of regeneration, e.g.

Abstract: A method for generating a chemically bonded organic functionality on the surface of particles or for condensing an organic compound onto the particle surface giving an organic coating is described. The method comprises a step of contacting a vapour containing an organic compound and a gaseous process stream containing flame-generated particles so as to react the organic compound with surface groups on the particles to give a chemically bonded organic functionality to the particle surface or so as to result in an organic coating.

Abstract: The invention relates to a membrane comprising a biocompatible block copolymer and has a porous structure with regularly distributed pores. A method for preparing said membranes is also provided.

Abstract: A method to control the velocity of a treadmill according to the walking velocity of the person that is using the treadmill. A reaction force is measured, which occurs when a longitudinal repulsion force is created between the treadmill (2) and the person (1). A signal representation for said reaction force is transmitted to a control unit. The control unit is used to control the velocity of the treadmill.

Abstract: The present invention provides polymer gel-processing techniques and polymer articles of high modulus.

Abstract: A method for forming an organic or partly organic switching device, comprising: depositing layers of conducting, semiconducting and/or insulating layers by solution processing and direct printing; defining microgrooves in the multilayer structure by solid state embossing; and forming a switching device inside the microgroove.

Abstract: The present invention provides new polyene macrolide derivatives which show very low toxicity while retaining high antifungal activity as compared with amphotericin B (AmB). These polyene macrolide derivatives comprise a polyene macrolide backbone having at least one free amino group, wherein the amino group is doubly alkylated with at least one hydrocarbon group carrying a total of at least two basic groups.

Abstract: A system for arm therapy of a user comprises a device for determining the position of the user, a first drive, an upper arm rotation module, an upper arm cuff, at least one hinge movably connecting the upper arm cuff and the first drive, a second drive, and a rotation drive provided on the upper arm rotation module itself. The upper arm cuff is connected to the arm of the user and has a substantially hollow-cylindrical shape when it is closed. The first drive and the second drive are adapted to place the upper arm rotation module in a defined spatial position, and the rotation drive is adapted to turn the upper arm cuff about its main axis relative to the outer part of the upper arm rotation module.

Abstract: This catalytically active or inactive diffuser is suitable for exhaust gas cleaning systems of internal combustion engines. It consists of a ceramic structure (8) which is obtained from a ceramized polyurethane foam. This ceramic structure (8) can be coated with surface area-increasing and/or oxygen-storing materials and/or noble metals in order to bring about a catalytic action with the gas molecules flowing through it. Because the diffuser is porous in every direction in its interior, a gas and its pressure can spread out equally on all sides through the entire diffuser volume. A virtually homogeneous velocity distribution arises over the entire flow cross section, and increased turbulence is obtained, which leads to more wall contacts of the harmful substance molecules. At the same time, the flow to and through downstream systems over their cross sections with homogeneously mixed exhaust gas including any reactants metered in is more uniform.

Abstract: Lubricating compositions, containing non-modified and modified multifunctional, polyionic copolymers and an aqueous lubricating medium, and methods for making and using such compositions are described herein. The lubricating compositions are applied to metal oxide surfaces, which are in contact with each other. The copolymers can serve as a surface protective boundary layer for the sliding surfaces, or they can also be used for the immobilization of further molecules, which can modify the tribological properties of the surfaces.

Abstract: A process for continuous or quasi-continuous purification of a multi-component mixture (F) by means of individual chromatographic columns through which the mixture is fed by means of at least one solvent (s), is proposed.