Patents Assigned to EIDOS THERAPEUTICS, INC.
  • Processes for preparing AG-10, its intermediates, and salts thereof
    Patent number: 11919865
    Abstract: Provided herein are improved processes for the preparation of a compound of Formula IX (AG-10). Also provided herein are pharmaceutically acceptable salts of Formula I and Formula Ib as well as crystalline types of Formula IX (AG-10). The processes described herein provide improved yields and efficiency, while the pharmaceutically acceptable salts and crystalline forms provide unexpected pharmacokinetic properties. Other features and aspects of the present disclosure will be apparent to a person of skill in the art upon reading the remainder of the specification.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: March 5, 2024
    Assignee: EIDOS THERAPEUTICS, INC.
    Inventors: Pooran Chand, Yogesh Kumar Gupta, Rakesh Kumar Kumawat, Mamoun Alhamadsheh, Robert Zamboni
  • Formulations of AG10
    Patent number: 11260047
    Abstract: The present disclosure provides high-load tablet formulations of AG10 or a pharmaceutically acceptable salt thereof. In some aspects, provided herein are table formulations of AG10 or a pharmaceutically acceptable salt thereof that include at least 40% or more AG10 by weight and at least one pharmaceutical excipient selected from one or more fillers, one or more binders, one or more disintegrants, and one or more lubricants.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: March 1, 2022
    Assignee: EIDOS THERAPEUTICS, INC.
    Inventors: Jesper Jernelius, Mark Michael Menning
  • Processes for preparing AG-10, its intermediates, and salts thereof
    Patent number: 11078162
    Abstract: Provided herein are improved processes for the preparation of a compound of Formula IX (AG-10). Also provided herein are pharmaceutically acceptable salts of Formula I and Formula Ib as well as crystalline types of Formula IX (AG-10). The processes described herein provide improved yields and efficiency, while the pharmaceutically acceptable salts and crystalline forms provide unexpected pharmacokinetic properties. Other features and aspects of the present disclosure will be apparent to a person of skill in the art upon reading the remainder of the specification.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: August 3, 2021
    Assignee: EIDOS THERAPEUTICS, INC.
    Inventors: Pooran Chand, Yogesh Kumar Gupta, Rakesh Kumar Kumawat, Mamoun Alhamadsheh, Robert Zamboni
  • Methods of treating TTR amyloidosis using AG10
    Patent number: 11058668
    Abstract: Described herein are methods for treating transthyretin (TTR) amyloidosis in a subject. The methods include specific dosing regimens that have great efficacy in treating the subjects and that are well tolerated in subjects.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: July 13, 2021
    Assignee: EIDOS THERAPEUTICS, INC.
    Inventors: Uma Sinha, Satish Rao
  • Process for preparing AG-10, its intermediates, and salts thereof
    Patent number: 10513497
    Abstract: Provided herein are improved processes for the preparation of a compound of Formula IX (AG-10). Also provided herein are pharmaceutically acceptable salts of Formula I and Formula Ib as well as crystalline types of Formula IX (AG-10). The processes described herein provide improved yields and efficiency, while the pharmaceutically acceptable salts and crystalline forms provide unexpected pharmacokinetic properties. Other features and aspects of the present disclosure will be apparent to a person of skill in the art upon reading the remainder of the specification.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: December 24, 2019
    Assignee: EIDOS THERAPEUTICS, INC.
    Inventors: Pooran Chand, Yogesh Kumar Gupta, Rakesh Kumar Kumawat, Mamoun Alhamadsheh, Robert Zamboni