Abstract: Methods of reducing hepatitis delta virus (HDV) viral loads in a patient are provided. In some embodiments, the method comprises treating the patient with lonafarnib-ritonavir co-therapy. In some embodiments, the method further comprises treating the patient with an interferon.
Type:
Grant
Filed:
October 26, 2016
Date of Patent:
September 18, 2018
Assignee:
Eiger BioPharmaceuticals, Inc.
Inventors:
David A. Cory, Ingrid Choong, Jeffrey S. Glenn
Abstract: Provided herein are quinolines, e.g., a compound of Formula (I) or (IB), pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of an endoplasmic reticulum stress-caused disease. Also provided herein are methods of their use for reducing endoplasmic reticulum stress and modulating the activity of a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase.
Abstract: Methods of reducing hepatitis delta virus (HDV) viral loads in a patient are provided. In some embodiments, the method comprises treating the patient with lonafarnib-ritonavir co-therapy. In some embodiments, the method further comprises treating the patient with an interferon.
Type:
Application
Filed:
October 26, 2016
Publication date:
February 16, 2017
Applicant:
Eiger BioPharmaceuticals, Inc.
Inventors:
David A. Cory, Ingrid Choong, Jeffrey S. Glenn