Abstract: The present invention provides methods and compositions for the treatment of subjects that have Dementia with Lewy Bodies (DLB) but have no substantial tau pathology. Subjects with DLB that have no substantial tau pathology are shown to be particularly responsive to treatment with a selective p38? mitogen activated protein kinase (MAPK) inhibitor compared to subjects with DLB that have substantial tau pathology.
Abstract: The present invention provides methods and compositions for the treatment of subjects that have Dementia with Lewy Bodies (DLB) but have no substantial tau pathology. Subjects with DLB that have no substantial tau pathology are shown to be particularly responsive to treatment with a selective p38? mitogen activated protein kinase (MAPK) inhibitor compared to subjects with DLB that have substantial tau pathology.
Abstract: Provided herein are co-crystal forms comprising 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (VX-745): and compositions thereof, useful as inhibitors of one or more protein kinases and which exhibit desirable characteristics for the same.
Type:
Grant
Filed:
September 18, 2018
Date of Patent:
October 11, 2022
Assignee:
EIP Pharma, LLC
Inventors:
John Jahangir Alam, Jeffrey Douglas Wilson
Abstract: Provided herein are co-crystal forms, and compositions thereof, useful as inhibitors of one or more protein kinases and which exhibit desirable characteristics for the same.
Abstract: Disclosed are oral pharmaceutical compositions of neflamapimod that exhibit suitable exposure for administration in humans and/or that maintain a desirable dissolution profile under standard storage conditions.
Type:
Grant
Filed:
March 12, 2019
Date of Patent:
May 19, 2020
Assignee:
EIP Pharma, LLC
Inventors:
John Jahangir Alam, Jeffrey Douglas Wilson
Abstract: The present invention provides methods and compositions for promoting recovery of function from neurologic injury, such as ischemic injury caused by acute stroke.
Abstract: The present invention provides compositions for reducing amyloid plaque burden associated with Alzheimer's disease and methods of using the same.
Abstract: The present invention provides compositions for reducing amyloid plaque burden associated with Alzheimer's disease and methods of using the same.
Abstract: The present invention provides compositions for reducing amyloid plaque burden associated with Alzheimer's disease and methods of using the same.
Abstract: The present invention provides compositions for reducing amyloid plaque burden associated with Alzheimer's disease and methods of using the same.