Patents Assigned to Eisai R&D Managment Co., Ltd.
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Patent number: 11129904Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.Type: GrantFiled: March 14, 2019Date of Patent: September 28, 2021Assignee: Eisai R&D Managment Co., Ltd.Inventors: Luigi Grasso, Jared Spidel, James Bradford Kline, Earl Albone
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Patent number: 10662251Abstract: Described herein are antibodies, and antigen-binding fragments thereof, that are specific for tumor endothelial marker 1 (TEM-1), related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing TEM-1-expressing cancers (such as melanoma, sarcoma, bladder cancer or colon cancer) using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of TEM-1 in a biological sample derived from a subject and comparing this level with the level of TEM-1 in a known standard or reference sample.Type: GrantFiled: August 23, 2017Date of Patent: May 26, 2020Assignee: Eisai R&D Managment Co, Ltd.Inventor: Daniel John O'Shannessy
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Patent number: 8834877Abstract: Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, fallopian tube cancer, ovarian cancer, or lung cancer, using the described antibodies, and antigen-binding fragments thereof. The methods involve determining the amount of folate receptor alpha in a sample derived from a subject and comparing this level with the level of folate receptor alpha in a control sample or reference sample.Type: GrantFiled: March 13, 2013Date of Patent: September 16, 2014Assignee: Eisai R&D Managment Co., Ltd.Inventor: Daniel John O'Shannessy
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Patent number: 8410277Abstract: It is an object of the present invention to provide an efficient method for manufacturing heterocycle-substituted pyridine derivatives. The present invention provides a method for manufacturing a compound represented by the following formula (I): the method including reacting a compound represented by the following formula (III): and a compound represented by the following formula (II): in a solvent and in the presence of a palladium catalyst and a base, wherein R1 represents a hydrogen atom, etc.; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group that may be protected with a protective group, etc.; one of X and Y represents a nitrogen atom and the other represents a nitrogen atom or an oxygen atom; Q represents a leaving group; the ring A represents a 5- or 6-member heteroaryl ring or a benzene ring, which may have one or two halogen atoms or C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, etc.Type: GrantFiled: December 25, 2008Date of Patent: April 2, 2013Assignee: Eisai R&D Managment Co., Ltd.Inventors: Jun Niijima, Kazuhiro Yoshizawa, Yuki Kosaka, Shinya Abe
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Patent number: 8183264Abstract: The present invention provides an antifungal agent that has excellent antifungal action, and is also excellent in terms of its properties, safety, and metabolic stability.Type: GrantFiled: September 20, 2007Date of Patent: May 22, 2012Assignee: Eisai R&D Managment Co., Ltd.Inventors: Masayuki Matsukura, Satoshi Inoue, Keigo Tanaka, Norio Murai, Shuji Shirotori
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Publication number: 20120115951Abstract: A cardiac myocyte protective agent, comprising a compound represented by the formula (Ia) below, a pharmaceutically acceptable salt thereof, or a solvate thereof:Type: ApplicationFiled: September 8, 2006Publication date: May 10, 2012Applicant: Eisai R & D Managment Co., LtdInventors: Masaharu Akao, Akinori Akaike, Toru Kita, Yasuki Kihara
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Patent number: 7638490Abstract: Relaxin-3 is found to have feeding-stimulating activity, body weight increasing activity, and fat weight increasing activity when intracerebroventricularly administered to rats through observation of amount of feeding, body weight and fat weight after administration of relaxin-3. This invention includes: a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing the polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of the polypeptide; a kit for screening; and an agent with a substance which inhibits expression of the polypeptide, such as a feeding-suppressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.Type: GrantFiled: February 9, 2005Date of Patent: December 29, 2009Assignee: Eisai R&D Managment Co., Ltd.Inventors: Takayuki Hida, Tomoko Sekiya, Toru Sawai, Takashi Seiki, Eiki Takahashi, Michiko Kosasa, Kokichi Harada, Tohru Arai
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Publication number: 20080194559Abstract: A therapeutic agent for subarachnoid hemorrhage or a drug for improving prognosis of subarachnoid hemorrhage, comprising a compound having a PAR1 inhibitory effect, its pharmaceutically acceptable salt or a hydrate thereof.Type: ApplicationFiled: September 2, 2005Publication date: August 14, 2008Applicants: Eisai R.& D Managment Co., Ltd., Kyushu University National University CorporationInventors: Katsuya Hirano, Yoshihisa Maeda, Tomio Sasaki, Hideo Kanaide, Yasutoshi Kai