Patents Assigned to El Khoury and Stein Ltd.
  • Topical application of opioid analgesic drugs such as morphine
    Patent number: 6787149
    Abstract: The invention is directed to methods and pharmaceutical compositions for the topical administration of opioid analgesic drugs such as morphine. In particular, the invention relates to topical administration of an opioid analgesic agent, e.g., morphine sulfate, to produce a localized analgesic effect in inflamed skin or mucosal tissue, and without a transdermal or transmucosal migration of opioid agent, e.g., into the systemic circulation.
    Type: Grant
    Filed: January 10, 2000
    Date of Patent: September 7, 2004
    Assignee: El Khoury and Stein Ltd.
    Inventors: George F. El Khoury, Christoph Stein
  • Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics
    Patent number: 5948389
    Abstract: The present invention is a method for enhancing the analgesic efficacy of a locally applied opioid analgesic or local anesthetic agent in a mammal having an impermeable perineurium barrier sheet about the peripheral sensory nerves at the site of action of the analgesic or anesthetic agent. The method involves applying to that site an effective amount of the analgesic or anesthetic agent dissolved in a hyperosmolar solution having an osmolality of above 300 mOsm/l.
    Type: Grant
    Filed: September 3, 1997
    Date of Patent: September 7, 1999
    Assignee: El Khoury & Stein, Ltd.
    Inventor: Christoph Stein
  • Topical application of opioid drugs such as morphine for relief of itching and skin disease
    Patent number: 5866143
    Abstract: The topical application of an opioid analgesic drug to an area of itching and/or skin irritation of a patient, including providing a quantity of an opioid analgesic drug, and mixing the opioid analgesic drug with a non-transdermal carrying agent. Applying the mixture of the opioid analgesic drug and non-transdermal carrying agent to the area of the patient to produce a reduction in itching and/or skin disease.
    Type: Grant
    Filed: October 15, 1996
    Date of Patent: February 2, 1999
    Assignee: El Khoury and Stein, Ltd.
    Inventor: George F. Elkhoury