Abstract: In joint reconstruction, repair and cushioning applications, a synthetic polypeptide material is useful that contains cross-linked polypeptides that are modeled on human elastin or other fibrous proteins. The polypeptides comprise at least three consecutive beta-sheet/beta-turn structures and at least one amino acid residue that participates in cross-linking.
Type:
Grant
Filed:
May 6, 2008
Date of Patent:
February 21, 2012
Assignees:
Hospital For Sick Children, Elastin Specialties, Inc.
Inventors:
Fred Keeley, Aser Rothstein, Steven Rothstein, Kimberly Woodhouse