Patents Assigned to Elbion AG
  • 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
    Patent number: 7419987
    Abstract: 7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds are also provided.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: September 2, 2008
    Assignee: Elbion AG
    Inventors: Norbert Höfgen, Ute Egerland, Thomas Kronbach, Degenhard Marx, Stefan Szelenyi, Hildegard Kuss, Emmanuel Polymeropoulos
  • Use of the non-opiate analgesic drug flupirtine for the treatment of overactive bladder and associated diseases including urge incontinence, urinary flow problems as a result of prostate hyperplasia and irritable bowel syndrome
    Patent number: 7309713
    Abstract: The present invention is directed to the prevention, reversal and medical treatment of lower urinary tract dysfunction including bladder instability and other related diseases as described below including urinary flow problems, urgency and incontinence as a result of prostate hyperplasia (BPH) and to the prevention, reversal and medical treatment of irritable bowl syndrome (IBS) with special focus on the diarrhea-predominant and mixed diarrhea-constipation type IBS, both in human beings and animals.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: December 18, 2007
    Assignee: Elbion AG
    Inventors: Chris Rundfeldt, Hildegard Kuss, Regina Draheim, Katrin Bernoester
  • 7-azaindoles and the use thereof as therapeutic agents
    Patent number: 7211583
    Abstract: The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: May 1, 2007
    Assignee: Elbion AG
    Inventors: Nobert Höfgen, Hildegard Kuss, Matthias Olbrich, Ute Egerland, Chris Rundfeldt, Karin Steinike, Rudolf Schindler
  • 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same
    Patent number: 7169787
    Abstract: The invention relates to new 7-azaindoles, their use as inhibitors of phosphodiesterase 4 and to methods for their synthesis.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: January 30, 2007
    Assignee: Elbion AG
    Inventors: Norbert Höfgen, Ute Egerland, Thomas Kronbach, Degenhard Marx, Stefan Szelenyi, Hildegard Kuss, Emmanuel Polymeropoulos
  • Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them
    Patent number: 7166637
    Abstract: The invention relates to substituted 4- or/and 7-hydroxyindoles, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active compounds for treating diseases which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 4 activity in immunocompetent cells (e.g. macrophages and lymphocytes).
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: January 23, 2007
    Assignee: Elbion AG
    Inventors: Norbert Höfgen, Hildegard Kuss, Ute Egerland, Chris Rundfeldt, Helge Hartenhauer, Antje Gasparic
  • Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation
    Patent number: 7161009
    Abstract: The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: January 9, 2007
    Assignee: Elbion AG
    Inventors: Norbert Höfgen, Ute Egerland, Hildegard Poppe, Degenhard Marx, Stefan Szelényi, Thomas Kronbach, Emmanuel Polymeropoulos, Sabine Heer
  • Process for preparing high-purity hydroxyindolylglyoxylamides
    Patent number: 7122674
    Abstract: The invention relates to a process for preparing hydroxyindolylglyoxylamides in high yields and particularly pure form.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: October 17, 2006
    Assignee: Elbion AG
    Inventors: Hans-Joachim Jänsch, Helge Hartenhauer, Hans Stange, Norbert Höfgen, Jürgen Schäfer
  • 4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents
    Patent number: 7067536
    Abstract: The invention relates to substituted 4-, 6- or 7-hydroxyindoles with N-oxide groups, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: June 27, 2006
    Assignee: Elbion AG
    Inventors: Nobert Hofgen, Hildegard Kuss, Karin Steinike, Ute Egerland, Chris Rundfeldt
  • Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation
    Patent number: RE38624
    Abstract: The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: October 12, 2004
    Assignee: Elbion AG
    Inventors: Norbert Hofgen, Ute Egerland, Hildegard Kuss, Degenhard Marx, Stefan Szelenyi, Thomas Kronbach, Emmanuel Polymeropoulos, Sabine Heer