Abstract: A vial adaptor for releasably holding a vial (1010) and releasable connection to an injector (1008) comprising: a dual-sleeved member (11) comprising a forward facing sleeve (12) and a rearward facing sleeve (16) adapted to operably engage a front end of a forward housing (1040) of said injector (1008), and comprising a vial stopper piercing member (46); and a vial engaging element (60) adapted to slidingly translate within said forward facing sleeve (12) and releasibly hold said vial (1010) in a position whereby said vial stopper piercing member (46) pierces a stopper of said vial (1010), said vial engaging element (60) adapted to allow forward movement of a plunger of said injector (1008) when said vial (1010) is in said position. In other aspects, a vial-stopper piercing spike and a method of manufacturing same is described.