Abstract: A new mechanism of therapeutic action of electromagnetic fields, based upon systemic effect, applies selected EMF signals to cause efficacious therapeutic effects at sites distant from the point of application. The method of generating specific EMF waveshape and application of this exogeneous signal for therapeutic purposes allows the benefit to be achieved via the systemic effect. The EMF signals take the form of a repetitive sequence of semi sinewaves, resulting in a pulsating waveform occurring at a frequency in the range of from about 50 to about 300 pulses per second. Bridge rectification is applied to a sinusoidal signal, and a resultant therapy signal takes the form of a repetitive sequence of semi sinewaves of up to about 300 pps with a periodically recurring DC component. The shape of alternating pulses in the resultant therapy signal is modified under computer control to achieve therapeutic effects. Flux densities in the range of several hundred Gauss up to several thousand Gauss are generated.