Patents Assigned to Eli Lilly and Company
  • Benzothiophenes compounds which have useful pharmaceutical activity
    Patent number: 6090843
    Abstract: This invention provides novel benzothiophene compounds of the formula I: ##STR1## which are useful for the treatment of the various medical conditions associated with postmenopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus, and cervix. The present invention further relates to pharmaceutical formulations of compounds of formula I.
    Type: Grant
    Filed: August 4, 1998
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: Henry Uhlman Bryant, Jeffrey Alan Dodge
  • Naphthyl glyoxamides as SPLA.sub.2 inhibitors
    Patent number: 6090850
    Abstract: A class of novel naphthyl glyoxamide compounds of formula (I) is disclosed together with a process for making the novel naphthyl glyoxamide compounds and the use of such compounds for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: Theodore Goodson, Jr., David K. Herron
  • Processes for preparing benzothiophenes
    Patent number: 6090949
    Abstract: The present invention relates to intermediates and processes for preparing benzothiophenes.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: John McNeill McGill, III, Jerry Wayne Misner, Tony Yantao Zhang
  • Method for treating excessive aggression
    Patent number: 6090829
    Abstract: The present invention provides a method of treating conduct disorder in a human using a compound of formula (I) ##STR1##
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: Neil C Bodick, Franklin P Bymaster, Harlan E Shannon
  • Tetrahydro-beta-carbolines
    Patent number: 6090945
    Abstract: The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided 3-ethanamine and 3-ethanamine related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, David L. Nelson
  • Processes and intermediates useful to make antifolates
    Patent number: 6090168
    Abstract: The present application relates to a series of novel sulfonic acid metal cation salts of the formula ##STR1## which are useful intermediates to prepare antifolate 5-substituted pyrrolo[2,3-d]pyrimidines. The present invention also relates to a novel process for preparing the sulfonic acid metal cation salts and to a novel process for preparing aldehydes of the formula ##STR2## from the corresponding sulfonic acid metal cation salts.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: Douglas Patton Kjell, Brian James Slattery, Charles Jackson Barnett
  • Antithrombotic agents
    Patent number: 6090787
    Abstract: This invention relates to peptide derivatives, pharmaceutical formulations containing those compound and methods of their use as thrombin inhibitors.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: Aaron L. Schacht, Gerald F. Smith, Michael R. Wiley
  • Rhesus neuropeptide Y1 receptor
    Patent number: 6087154
    Abstract: This invention describes a rhesus receptor, designated the rhesus Y1 receptor, having affinity for neuropeptide Y, pancreatic polypeptide, and peptide YY. This invention also encompasses nucleic acids encoding this receptor, or a fragment thereof, as well as methods employing this receptor and the nucleic acid compounds.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: July 11, 2000
    Assignee: Eli Lilly and Company
    Inventors: Melvyn Baez, Carolyn Ann George
  • Method for preserving animal hides
    Patent number: 6086633
    Abstract: Compositions and methods for preserving untanned animal hides, wherein the compositions comprise 50-95% (w/w) of a polyether antibiotic and 5-25% (w/w) of a surface-acting agent. In these compositions, greater than 90% of the polyether antibiotic has a particle size of less than 25 microns, and the surface-acting agent is present in an amount that is effective to disperse the polyether antibiotic uniformly in an aqueous suspension.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: July 11, 2000
    Assignee: Eli Lilly and Company
    Inventors: Rogerio B DeCampos, Martin K Kemmerling
  • Pharmaceutical formulations and applications thereof for the treatment of estrogen deprivation syndrome
    Patent number: 6087378
    Abstract: Formulations and applications thereof are described which are useful for the inhibition of various medical conditions associated with estrogen deprivation syndrome including osteoporosis and hyperlipidemia utilizing compounds represented by the following structure where X is a halogen.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: July 11, 2000
    Assignee: Eli Lilly and Company
    Inventors: George Joseph Cullinan, Brian Stephen Muehl, Kenneth Jeff Thrasher
  • Anti-viral compounds
    Patent number: 6087374
    Abstract: The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof. These compounds inhibit the growth of piconaviruses, such as rhinoviruses, Hepatitus viruses, cardioviruses, polioviruses, enteroviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: July 11, 2000
    Assignee: Eli Lilly and Company
    Inventors: Kurt D. Schladetzky, Wayne A. Spitzer, Michael S. Vannieuwenhze
  • Glycosyltransferase gene gtfA from Amycolatopsis orientalis
    Patent number: 6087143
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfA of Amycolatopsis orientalis. Also provided are vectors carrying the gtfA gene, transformed heterologous host cells for expressing the GtfA protein, and methods for producing glycopeptide compounds using the cloned gtfA gene.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: July 11, 2000
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Potassium channel inhibitors
    Patent number: 6083986
    Abstract: Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.
    Type: Grant
    Filed: July 15, 1997
    Date of Patent: July 4, 2000
    Assignees: ICAgen, Inc., Eli Lilly & Company
    Inventors: Neil Alexander Castle, Sean Patrick Hollinshead, Philip Floyd Hughes, Jose Serafin Mendoza, Joseph Wendell Wilson, George Salvatore Amato, Serge Beaudoin, Michael Gross, Grant McNaughton-Smith
  • Method for preparing and selecting pharmaceutically useful sulfur-bridged bi- and triaromatic ring compounds from a structurally diverse universal library
    Patent number: 6080587
    Abstract: Methods for rapidly generating large rationally designed libraries of structurally-diverse small molecular weight compounds using a multicombinatorial approach.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: June 27, 2000
    Assignee: Eli Lilly and Company
    Inventors: Michael Raymond Pavia, Harold Vernon Meyers
  • Pulmonary and nasal delivery of raloxifene
    Patent number: 6080762
    Abstract: The present invention relates to formulations and methods for pulmonary and nasal administration of raloxifene.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: June 27, 2000
    Assignee: Eli Lilly and Company
    Inventors: Darrel LaVern Allen, Ronald Keith Wolff, Paula Ann Leiter, Richard Leon Tielking
  • Treatment of central nervous system disorders with selective estrogen receptor modulators
    Patent number: 6077852
    Abstract: The present invention provides a method of treating depression, mood swings, or Alzheimer's disease in a patient in need of such treatment by administering a selective estrogen receptor modulating compound of the formula ##STR1## in which R.sup.1 and R.sup.2 are independently hydroxy and alkoxy of one to four carbon atoms; and R.sup.3 and R.sup.4 are independently methyl or ethyl, or R.sup.3 and R.sup.4, taken together with the nitrogen atom to which they are attached, form a pyrrolidino, methyl-pyrrolidino, dimethylpyrrolidino, piperidino, morpholino, or hexamethyleneimino ring.
    Type: Grant
    Filed: April 9, 1998
    Date of Patent: June 20, 2000
    Assignee: Eli Lilly and Company
    Inventors: Kelly Renee Bales, Henry Uhlman Bryant, Steven Marc Paul, Mary Patricia Knadler
  • 5HT receptor binding benzimidazolylpiperidines
    Patent number: 6075039
    Abstract: A pharmaceutical compound of the formula ##STR1## in which X is --CR'R"-- or --C(O)-- where R' and R" are each hydrogen, C.sub.1-6 alkyl or optionally substituted phenyl, Y is oxygen or sulphur, R.sup.1, R.sup.2 and R.sup.7 are each selected from halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, nitro, cyano, amino, phenyl, phenoxy, benzyl, benzyloxy, acylamino, C.sub.1-4 alkylsulphonylamino, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphonyl, carboxamido, sulphonamido, hydroxy, methylenedioxy, carboxy, and heteroaryl, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each hydrogen, C.sub.1-6 alkyl or optionally substituted phenyl, n, m and p are each 0, 1, 2 or 3;or a salt or ester thereof.
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: June 13, 2000
    Assignee: Eli Lilly and Company Limited
    Inventors: Peter Thaddeus Gallagher, Martin Victor Miles, William Martin Owton, Colin William Smith
  • Streptococcus pneumoniae gene sequence HI1146
    Patent number: 6074847
    Abstract: The invention provides isolated nucleic acid compounds encoding HI1146 of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: June 13, 2000
    Assignee: Eli Lilly and Company
    Inventors: Robert Brown Peery, Paul Luther Skatrud, Patti Jean Treadway, Michele Louise Young Bellido
  • Carbamoyl substituted heterocycles
    Patent number: 6075147
    Abstract: This invention relates to carbamoyl substituted heterocycles which are .omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring and which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as pharmaceutical formulations containing them, methods for their use, and processes and intermediates for their preparation.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: June 13, 2000
    Assignee: Eli Lilly and Company
    Inventors: Joseph Anothony Jakubowski, Dale Eugene Mais, Kumiko Takeuchi
  • Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
    Patent number: 6075146
    Abstract: The invention relates to intermediates and processes for producing benzothiophenes employing hydroxylamines.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: June 13, 2000
    Assignee: Eli Lilly and Company
    Inventor: Erik Christopher Chelius