Patents Assigned to Eli Lilly & Company
  • 1-phenylpyrazole-4,5-dicarboxylic acid derivatives, composition containing them, and pollen formation inhibiting method of using them
    Patent number: 4801326
    Abstract: Pollen formation in cereal grain plants is inhibited by application of a 4,5-dicarboxy or 5-carboxamido-4-carboxy (or derivatized carboxy)-1-(3,5-disubstitutedphenyl)pyrazole. Use of the compounds facilitates the production of hybrid seed.
    Type: Grant
    Filed: January 15, 1988
    Date of Patent: January 31, 1989
    Assignee: Eli Lilly and Company
    Inventors: Stephen A. Ackmann, James R. Beck, Fred L. Wright
  • 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
    Patent number: 4801712
    Abstract: D-2-Alkyl(or phenyl)thio-6-n-alkylergolines or .+-.-2-alkyl(or phenyl)thio-4-dialkylaminotetrahydrobenz[c,d]indoles, dopamine D-1 antagonists.
    Type: Grant
    Filed: June 11, 1987
    Date of Patent: January 31, 1989
    Assignee: Eli Lilly and Company
    Inventors: Bennett C. Laguzza, Cynthia L. Nichols, Nicholas J. Bach
  • Aromatase inhibitors
    Patent number: 4801594
    Abstract: This invention provides azole derivatives, their pharmaceutical formulations, and their use in methods of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: January 31, 1989
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Charles D. Jones
  • Thiaiazolyl benzamides
    Patent number: 4801718
    Abstract: N-Aryl benzamides wherein the aryl group is a nitrogen containing heterocycle are useful as selective herbicidal agents. Compositions containing the novel benzamides and a herbicidal method of selective weed control are disclosed.
    Type: Grant
    Filed: December 5, 1985
    Date of Patent: January 31, 1989
    Assignee: Eli Lilly and Company
    Inventor: Kenneth W. Burow, Jr.
  • Hydrazone immunoglobulin conjugates
    Patent number: 4801688
    Abstract: Immunoglobulin conjugates formed by reaction of an antineoplastic indole-dihydroindole vinca alkaloid containing a hydrazine group attached at C-3 or C-4 with an oxidized glycoprotein containing aldehyde groups.
    Type: Grant
    Filed: October 7, 1987
    Date of Patent: January 31, 1989
    Assignee: Eli Lilly and Company
    Inventors: Bennett C. Laguzza, Cynthia L. Nichols
  • Diphenylmethanone compounds and anti-inflammatory use thereof
    Patent number: 4801616
    Abstract: This invention provides certain diphenylmethane derivatives, their pharmaceutical formulations, and their use in treating inflammation and arthritis in mammals.
    Type: Grant
    Filed: March 25, 1986
    Date of Patent: January 31, 1989
    Assignee: Eli Lilly and Company
    Inventor: D. Mark Gapinski
  • Process for producing the A-21978C antibiotics
    Patent number: 4800157
    Abstract: Improved fermentation process for producing the gram-positive A-21978C antibiotics which comprises cultivating a new strain of Streptomyces roseosporus, NRRL 15998, and the biologically purified culture of this microorganism are provided.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: January 24, 1989
    Assignee: Eli Lilly and Company
    Inventors: Tom E. Eaton, Lynda M. Ford, Otis W. Godfrey, Jr., Mary L. B. Huber, Milton J. Zmijewski, Jr.
  • Optionally substituted (3.beta.-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement
    Patent number: 4798834
    Abstract: A therapeutic method employing 2,3-dihydroergolines is disclosed. Said method enhances serotonergic function in the nervous system of a mammal in need thereof, thereby finding application in serotonin-mediated physiological manifestations including memory, depression, anxiety, pain and appetite. Also disclosed are pharmaceutical compositions containing said 2,3-dihydroergolines in admixture with pharmaceutically acceptable diluents and carriers.
    Type: Grant
    Filed: August 31, 1987
    Date of Patent: January 17, 1989
    Assignee: Eli Lilly and Company
    Inventors: Leander Merritt, John S. Ward
  • Stabilized pergolide compositions
    Patent number: 4797405
    Abstract: Pharmaceutical compositions containing pergolide or a salt thereof stabilized to decomposition by light by incorporation therewith of a stabilizing agent selected from polyvinylpyrrolidone, .alpha.-tocopherol succinate and propyl gallate.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: January 10, 1989
    Assignee: Eli Lilly and Company
    Inventors: James W. Conine, Julian L. Stowers
  • Orally administerable sustained release pharmaceutical formulations
    Patent number: 4797286
    Abstract: This invention provides orally administerable pharmaceutical formulations having a semi-solid matrix containing a hydrophilic substance capable of creating channels in a hydrophobic carrier matrix thereby providing a sustained rate of release of an active agent from the formulation.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: January 10, 1989
    Assignee: Eli Lilly and Company
    Inventors: Arvind L. Thakkar, Lowell L. Gibson
  • Nicarbazin feed premix
    Patent number: 4797275
    Abstract: This invention provides a novel formulation of an animal feed premix in substantially granular and non-dusty form comprising finely powdered nicarbazin and a water-soluble adjuvant having a melting point in the range from about 50.degree. to about 85.degree..
    Type: Grant
    Filed: September 26, 1985
    Date of Patent: January 10, 1989
    Assignee: Eli Lilly and Company
    Inventors: Norman D. Brooks, Rebecca A. Kenyon, Peter W. Vanevenhoven
  • Water-in-oil microemulsions for cosmetic uses
    Patent number: 4797272
    Abstract: The present invention provides water-in-oil microemulsions suitable for cosmetic uses containing moisturizing agents or sunscreens.
    Type: Grant
    Filed: November 15, 1985
    Date of Patent: January 10, 1989
    Assignee: Eli Lilly and Company
    Inventors: Edwards E. Linn, Michael P. West
  • Novel expression control sequences
    Patent number: 4795706
    Abstract: The present invention comprises novel expression control sequences that promote transcription of DNA. The novel sequences have been positioned for expression of structural genes encoding bovine growth hormone derivatives on recombinant DNA expression vectors. The novel expression control sequences function in both Gram-positive and Gram-negative organisms and can be constructed by either DNA synthesizing instruments or by conventional modified phosphotriester methodology.
    Type: Grant
    Filed: January 31, 1985
    Date of Patent: January 3, 1989
    Assignee: Eli Lilly and Company
    Inventors: Hansen M. Hsiung, Dennis P. Smith
  • 1,2,4-trisubstituted diazolidinones
    Patent number: 4795815
    Abstract: 1,2,4-Trisubstituted diazolidinones are intermediates to bicyclic pyrazolidinone antimicrobial compounds.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: January 3, 1989
    Assignee: Eli Lilly and Company
    Inventor: Robert J. Ternansky
  • Fungicidal pyridazines
    Patent number: 4791110
    Abstract: Plants are protected from the damaging effects of Phycomycetous fungi by a series of pyridazines of formula ##STR1## wherein R.sup.3 is chloro, bromo, methyl, cyano or iodo;R is chloro, bromo, iodo, methyl, cyano or furan-2-ylmethoxy;R.sup.1 is hydrogen, methyl, ethyl or n-propyl;R.sup.2 is ##STR2## X is fluoro, chloro, bromo or iodo; X.sup.1 and X.sup.2 independently represent X or hydrogen, provided that no more than one of X.sup.1 and X.sup.2 is hydrogen;R.sup.4 is hydrogen, chloro, bromo, methyl or ethyl;R.sup.5 is hydrogen, chloro, methyl, ethyl, chloromethyl or dichloromethyl;or R.sup.4 and R.sup.5 combine with the group to which they are attached to form a C.sub.3 -C.sub.7 cycloalkyl group substituted with a R.sup.1 group;R.sup.6 is hydrogen, chloro, bromo, methyl or ethyl;R.sup.7 is hydrogen, methyl, ethyl, chloromethyl or dichloromethyl;one of m and n is 0 or 1, and the other is 0;p is 0-4.
    Type: Grant
    Filed: May 5, 1986
    Date of Patent: December 13, 1988
    Assignee: Eli Lilly and Company
    Inventors: Wendell R. Arnold, William C. Dow, George W. Johnson
  • 1-Carbacephalosporin antibiotics
    Patent number: 4791106
    Abstract: 7.beta.-Acylamino-3-alkoxycarbonyl-(and 3-keto)-1-carba(1-dethia)-3-cephem-4-carboxylic acids and derivatives and related 3-substituted compounds are provided as antibiotics useful for treating infections in man and animals. Pharmaceutical formulations comprising the antibiotics and intermediates a process for their preparation are provided. Exemplary compounds provided are 7.beta.-[D-(2-phenyl-2-aminoacetyl)amino]-3-methoxycarbonyl-1-carba(1-deth ia)-3-cephem-4-carboxylic acid and 7.beta.-[2-(2-aminothiazol-4-yl)-2-methoxyimino-acetamido]-3-acetyl-1-carb a(1-dethia)-3-cephem-4-carboxylic acid.
    Type: Grant
    Filed: June 26, 1987
    Date of Patent: December 13, 1988
    Assignee: Eli Lilly and Company
    Inventor: John E. Munroe
  • Recombinant DNA expression vectors useful in bacillus and other host cells
    Patent number: 4783405
    Abstract: Recombinant DNA expression vectors for use in Bacillus and other host cells are disclosed. The vectors comprise the veg promoter sequence of Bacillus subtilis, a novel ribosome binding site-containing sequence and a sequence that codes for a functional polypeptide. The ribosome binding site-containing sequence is synthesized in accordance with conventional procedures while the veg promoter sequence can be obtained from E. coli K12 JA221/pMS480 (NRRL B-15258). Various sequences that codes for functional polypeptides and method for their expression in Bacillus are also disclosed.
    Type: Grant
    Filed: September 26, 1984
    Date of Patent: November 8, 1988
    Assignee: Eli Lilly and Company
    Inventors: Steven Kovacevic, James R. Miller, Hansen M. Hsiung
  • Decyanation of pergolide intermediate
    Patent number: 4782152
    Abstract: The present invention provides a process for decyanating a pergolide intermediate with an alkali metal hydroxide in an alcoholic solvent having a boiling point greater than about 100.degree. C. at a temperature in the range of about 100.degree. C. to about 175.degree. C.
    Type: Grant
    Filed: August 16, 1985
    Date of Patent: November 1, 1988
    Assignee: Eli Lilly and Company
    Inventor: Jerry W. Misner
  • 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof
    Patent number: 4782144
    Abstract: Crystalline p-nitrobenzyl 7.beta.-phenoxyacetylamino-3-hydroxy-1-carba(dethia)-3-cephem-4-carboxylat e and the crystalline mono-acetic acid solvate thereof are provided by mixing a carboxylic acid or a sulfonic acid with a solution of the 3-hydroxy ester in DMF or DMAC. Acetic acid provides the crystalline acetic acid solvate while other acids provide crystalline non-solvated 3-hydroxy ester. The crystalline forms are useful purified intermediates to antibiotics.
    Type: Grant
    Filed: September 14, 1987
    Date of Patent: November 1, 1988
    Assignee: Eli Lilly and Company
    Inventor: John P. Gardner
  • Selective chemical removal of a protein amino-terminal residue
    Patent number: 4782139
    Abstract: The invention relates to a process and compounds useful therein for producing a compound having an amino acid sequence defining a biologically active peptide or protein from a compound of the formulaH--X--Pro--Peptidein which X is the residue of a naturally occurring amino acid and Peptide is a sequence of amino acids defining a biologically active peptide or protein, which comprises subjecting H--X--Pro--Peptide to conditions under which a diketopiperazine of the H--X--Pro-- moiety is formed with accompanying cleavage and release of Peptide.
    Type: Grant
    Filed: October 23, 1986
    Date of Patent: November 1, 1988
    Assignee: Eli Lilly and Company
    Inventors: Richard D. DiMarchi, Gerald S. Brooke