Abstract: Hydantoin compounds are described of the formula (I) : ##STR1## wherein R.sup.1 is phenyl, C.sub.1-4 hydroxyalkyl or carboxy C.sub.1-4 alkyl and wherein R.sub.2 is C.sub.1-6 alkyl. The compounds are useful in the prophylactic treatment of immediate hypersensitivity diseases including asthma.
Type:
Grant
Filed:
May 14, 1979
Date of Patent:
October 28, 1980
Assignee:
Eli Lilly Industries Limited
Inventors:
William B. Jamieson, William J. Ross, Robin G. Simmonds, John P. Verge
Abstract: The invention provides novel 5- and 6-benzoxazolyl alkanoic acids, optionally substituted in the 2-position, and derivatives thereof which possess anti-inflammatory, anti-pyretic and analgesic activity. Also provided is a process for preparing such compounds by cyclizing an appropriately substituted o-aminophenol and, if necessary, converting the resultant benzoxazole to the desired compound.
Type:
Grant
Filed:
June 17, 1975
Date of Patent:
May 3, 1977
Assignee:
Eli Lilly Industries Limited
Inventors:
Delme Evans, David William Dunwell, Terence Alan Hicks