Abstract: The present invention provides compounds of the Formula below: [Formula should be inserted here] Where A, X, R, and R2-R3 are as described herein; methods of treating patients for hypertriglyceridemia and cardiovascular disease including dyslipidemia and atherosclerosis, and processes for preparing the compounds.

Abstract: The present invention provides a compound of the Formula (I) below: wherein R1 is selected from the group consisting of H, CH3, CN, —CH2CN, —C(CH3)2CN, F, Cl, and Br; R2 is selected from the group consisting of H, —O(C1-C3alkylene)R4, —CH2CN, CN, —OCH3, CF2, —C(CH3)2CN, —C(CH3)2, —S(O)2CH3, —S(O)2NH2, and —OCF2; R3 is selected from the group consisting of H, CH3, and —OCH3; and R4 is selected from the group consisting of H, —C(CH3)2CN, —OCH3, —S(O)2CH3, CN, and —C(CH3)2OH; or a pharmaceutical salt thereof, methods of treating type two diabetes using the compound and a process for preparing the compound.

Abstract: The present invention provides compounds having the formula: wherein R1 is selected from methyl, ethyl, propyl, cyclopropyl, and dimethyl, or a pharmaceutically acceptable salt thereof, along with methods and intermediates for their preparation, and uses thereof.

Abstract: The present invention provides novel mGlu2/3 agonists useful in the treatment of neurological or psychiatric disorders.

Abstract: The invention features methods and compositions for screening for agents that modulate replication of a virus, particularly Flaviviridae virus (particularly hepatitis C virus (HCV)), where the methods provide for detection of agents that modulate the binding of TBC and NS5A, the inhibition of TBC activity, inhibition of Rab1 activity, and/or the expression of the TBC protein and/or Rab1 protein. The invention also features methods of controlling viral replication, and agents useful in such methods.

Abstract: Selective norepinephrine reuptake inhibitors are useful for the prevention or treatment of hot flashes, vasomotor symptoms, impulse control disorders or personality change due to a general medical condition.

Abstract: A medication dispensing apparatus that provides a mechanical advantage. During dose preparing, a nut rotating element (410) and a screw element (368) are in a first axial arrangement such that a screwing motion of the nut rotating element and screw element relative to the apparatus housing that moves the elements a first axial distance from a home position screws a nut (364) along a drive member threaded shaft (362) a second axial distance different than the first axial distance. During dose dispensing, the nut rotating element and the screw element are in a second axial arrangement, whereby a screwing motion of the screw element relative to the housing back toward the home position advances a plunger (366) in the distal direction to axially advance the nut and thereby the drive member and a fluid container piston to dispense medicine.

Abstract: The present invention is a method for treating anxiety or mood disorders in elderly subjects comprising administering to the subject exhibiting an anxiety or mood disorder an effective amount of an agent that modulates A? in the subject.

Abstract: A flexible tube is sterilized and ready for coupling to sterile tubing in a sterile environment by steam sterilization in a closed environment in which steam pressure both inside and outside the flexible tube is the same. For this purpose, the flexible tube is coupled to a transfer cup which has door means sealingly attached at its mouth creating a chamber, which is openable when the coupling is to take place. An outlet from the transfer cup chamber thus defined allows sterilizing steam entering said chamber from the flexible tube with the door means in closed disposition to leave the transfer cup therethrough and flow around the exterior of the flexible tube at the same pressure as the steam within the tube. Once the flexible tube and transfer cup are sterilized, the flexible tube is coupled to the sterile tubing by admission of said tubing to the transfer cup chamber through the door means.

Abstract: A method and apparatus for generating a vapor/gas mixture includes storing a plurality of volatile liquids to provide the vapor component of the mixture, adding predetermined amounts of the volatile liquids and a dilution gas to a container, and thereafter removing the mixture to prepare a second vapor/gas mixture. In one approach, subsequent mixtures are prepared using different volatile liquids as the vapor component. Alternatively, a portion on the first vapor/gas mixture is removed from the container and then additional volatile liquid or dilution gas are added to the container to prepare a second vapor/gas mixture including the same vapor but at a different percentage in the mixture, or including additional vapors not used in the first vapor/gas mixture.