Abstract: The present invention relates to a vector, preferably included in a delivery vehicle, comprising no more than 100, preferably no more than 10, restriction sites recognized by the restriction enzymes encoded by each bacterium of a group of bacteria of interest. The invention also relates to the use of said vector, preferably included in a delivery vehicle, as a drug, especially in the treatment of a disease in a patient in need thereof.
Type:
Application
Filed:
June 23, 2021
Publication date:
December 9, 2021
Applicants:
Eligo Bioscience, Institut Pasteur
Inventors:
Antoine Decrulle, Jesus Fernandez Rodriguez, Xavier Duportet, David Bikard
Abstract: The present invention relates to a vector, preferably included in a delivery vehicle, comprising no more than 100, preferably no more than 10, restriction sites recognized by the restriction enzymes encoded by each bacterium of a group of bacteria of interest. The invention also relates to the use of said vector, preferably included in a delivery vehicle, as a drug, especially in the treatment of a disease in a patient in need thereof.
Type:
Grant
Filed:
September 10, 2020
Date of Patent:
August 3, 2021
Assignees:
Eligo Bioscience, Institut Pasteur
Inventors:
Antoine Decrulle, Jesus Fernandez Rodriguez, Xavier Duportet, David Bikard
Abstract: The present disclosure relates generally to bacterial delivery vehicles and their use in efficient transfer of a desired payload into a target bacterial cell of the microbiota of a subject. More specifically, the present disclosure relates to bacterial delivery vehicles with desired host ranges that can be used to efficiently transfer the desired payload in vivo to one or more target bacterial cells of the microbiota of a subject.
Abstract: The present invention relates to a vector, preferably included in a delivery vehicle, comprising no more than 100, preferably no more than 10, restriction sites recognized by the restriction enzymes encoded by each bacterium of a group of bacteria of interest. The invention also relates to the use of said vector, preferably included in a delivery vehicle, as a drug, especially in the treatment of a disease in a patient in need thereof.
Type:
Grant
Filed:
July 31, 2019
Date of Patent:
October 20, 2020
Assignees:
Eligo Bioscience, Institut Pasteur
Inventors:
Antoine Decrulle, Jesus Fernandez Rodriguez, Xavier Duportet, David Bikard
Abstract: The present invention relates to a vector, preferably included in a delivery vehicle, comprising no more than (100), preferably no more than (10), restriction sites recognized by the restriction enzymes encoded by each bacterium of a group of bacteria of interest. The invention also relates to the use of said vector, preferably included in a delivery vehicle, as a drug, especially in the treatment of a disease in a patient in need thereof.
Type:
Application
Filed:
February 2, 2018
Publication date:
August 6, 2020
Applicants:
Eligo Bioscience, Institut Pasteur
Inventors:
Antoine Decrulle, Jesus Fernandez Rodriguez, Xavier Duportet, David Bikard
Abstract: The present invention relates to a vector, preferably included in a delivery vehicle, comprising no more than 100, preferably no more than 10, restriction sites recognized by the restriction enzymes encoded by each bacterium of a group of bacteria of interest. The invention also relates to the use of said vector, preferably included in a delivery vehicle, as a drug, especially in the treatment of a disease in a patient in need thereof.
Type:
Application
Filed:
July 31, 2019
Publication date:
February 6, 2020
Applicants:
Eligo Bioscience, Institut Pasteur
Inventors:
Antoine Decrulle, Jesus Fernandez Rodriguez, Xavier Duportet, David Bikard