Patents Assigned to ELITechGroup MDX, LLC
  • Carborhodamine compounds and methods of preparation thereof
    Patent number: 11920040
    Abstract: The carborhodamine dyes disclosed herein are novel reagents suitable for automated incorporation of carborhodamine dyes into oligonucleotides that can be used in detection methods for nucleic acid targets. This disclosure provides an efficient and simple process for the preparation of carborhodamine compounds and introduces previously unknown reagents for the automated synthesis of oligonucleotide-carborhodamine conjugates.
    Type: Grant
    Filed: December 2, 2022
    Date of Patent: March 5, 2024
    Assignee: ELITECHGROUP MDX LLC
    Inventor: Eugeny A. Lukhtanov
  • CARBORHODAMINE COMPOUNDS AND METHODS OF PREPARATION THEREOF
    Publication number: 20230105320
    Abstract: The carborhodamine dyes disclosed herein are novel reagents suitable for automated incorporation of carborhodamine dyes into oligonucleotides that can be used in detection methods for nucleic acid targets. This disclosure provides an efficient and simple process for the preparation of carborhodamine compounds and introduces previously unknown reagents for the automated synthesis of oligonucleotide-carborhodamine conjugates.
    Type: Application
    Filed: December 2, 2022
    Publication date: April 6, 2023
    Applicant: ELITECHGROUP MDX LLC
    Inventor: Eugeny A. Lukhtanov
  • Carborhodamine compounds and methods of preparation thereof
    Patent number: 11618826
    Abstract: The carborhodamine dyes disclosed herein are novel reagents suitable for automated incorporation of carborhodamine dyes into oligonucleotides that can be used in detection methods for nucleic acid targets. This disclosure provides an efficient and simple process for the preparation of carborhodamine compounds and introduces previously unknown reagents for the automated synthesis of oligonucleotide-carborhodamine conjugates.
    Type: Grant
    Filed: September 23, 2021
    Date of Patent: April 4, 2023
    Assignee: ELITECHGROUP MDX LLC
    Inventor: Eugeny A. Lukhtanov
  • Duplex stabilizing fluorescence quenchers for nucleic acid probes
    Patent number: 11320376
    Abstract: Diaryl-azo derivatives are efficient fluorescence quenchers as well as nucleic acid duplex-stabilizing agents and are useful in oligonucleotide conjugates and probes. The oligonucleotide-quencher conjugates may be used in detection methods for nucleic acid targets.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: May 3, 2022
    Assignee: ELITECHGROUP MDX LLC
    Inventors: Eugeny A. Lukhtanov, Noah Scarr
  • NITRODIARYLETHENES AS FLUORESCENCE QUENCHERS FOR NUCLEIC ACID PROBES
    Publication number: 20220119424
    Abstract: Fluorescence quenching nitrodiarylethene analogs are useful in oligonucleotide conjugates and probes. These analogs, whose absorption spectra are substantially blue-shifted relatively to emission spectra of common fluorophores (such as fluorescein), do not need to rely on spectral overlap of quencher absorbance and fluorophore's emission for their quenching abilities. The oligonucleotide-quencher conjugates may be used in detection methods for nucleic acid targets.
    Type: Application
    Filed: December 21, 2021
    Publication date: April 21, 2022
    Applicant: ELITechGroup MDX, LLC
    Inventors: Eugeny A. Lukhtanov, Noah Scarr, Viachaslau Bernat