Abstract: The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.
Type:
Application
Filed:
July 2, 2012
Publication date:
November 1, 2012
Applicants:
ELIZABETH
Inventors:
Gwyneth Jane Farrar, Sophia Millington-Ward, Naomi Chadderton, Arpad Palfi, Mary O'Reilly, Paul Kenna, Peter Humphries