Abstract: The invention provides a connector for attaching a first part to a second part in a connection joint, the connector comprising a body attachable to the first part and comprising link element extending from the body, wherein the link comprises substantially opposing surfaces, each surface comprising a curved region configured to nest with a complimentary curved region of a washer of the connection joint, and further comprising an opening located substantially centrally within each curved region of the arm and passing through the arm.

Abstract: An Artificial Intelligence (AI) based computer system and method for determining one or more predicted requirements and/or events for a healthcare facility corresponding to a scheduled inflow of patients. Generated is a learning inference model using a machine learning and/or deep learning algorithm configured to capture data, from the computer network, containing information relating to patient inflow to the healthcare facility, wherein the data includes a purpose of stay for a patient. The captured data is analyzed, using the generated learning inference model, to generate, using at least a portion of the captured data, one or more predictions regarding one or more conditions to occur in the future that are associated with one or more resources of the healthcare facility associated with the purpose of stay for the patient. The one or more predictions are then analyzed, using the generated learning inference model, for recommending an allocation of at least one of the one or more.

Abstract: A method for measuring an electron signal or an electron induced signal may be provided. The method may include providing a threshold number of events or a threshold event rate for a pixel on a detector. The method may include collecting from the detector the threshold number of events or determining that the threshold event rate is achieved, wherein a signal at the detector is an electron signal or an electron induced signal from a sample. The method may include modulating an intensity of an electron source directed to the sample in response.

Abstract: A catheter-based ultrasound imaging system configured to provide a full circumferential 360-degree view around an intra-vascular/intra-cardiac imaging-catheter-head by generating a three-dimensional view of the tissue surrounding the imaging-head over time. The ultrasound imaging system can also provide tissue-state mapping capability. The evaluation of the vasculature and tissue characteristics include path and depth of lesions during cardiac-interventions such as ablation. The ultrasound imaging system comprises a catheter with a static or rotating sensor array tip supporting continuous circumferential rotation around its axis, connected to an ultrasound module and respective processing machinery allowing ultrafast imaging and a rotary motor that translates radial movements around a longitudinal catheter axis through a rotary torque transmitting part to rotate the sensor array-tip.

Abstract: The invention provides a backrest mounting system to mount a backrest to a wheelchair post. The mounting system comprises a locking peg that is receivable within a peg receiver. The peg receiver comprises a lock assembly comprising a locking member adapted to engage with the locking peg in a locked position. The locking peg comprises a latch pin housing extending along at least a portion of a length of the peg and also comprises a latch pin within the latch pin housing. The latch pin is slidable between a retracted position and an extended position in which the latch pin engages with and holds the locking member in an unlocked position to allow the locking peg to be readily retracted from the peg receiver.

Abstract: The present invention is directed to an RNAi-inducing agent capable of reducing and/or inhibiting the expression of proteins associated with the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Specifically, the RNAi-inducing agent is capable of reducing and/or inhibiting the expression of proteins expressed in the tight junction complex or supporting the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Methods using this RNAi-inducing agent are also contemplated.

Abstract: A heart valve therapeutic device (1) comprises a coaptation assist valve (20) comprising a conduit (2) with an outer surface (3) for coaption with the native leaflets, and a prosthetic flow valve (5) mounted within the conduit (2) to allow one-way flow through the conduit (2). Support for the coaptation assist valve (20) is provided by a support (10) for positioning the conduit (2) across the native leaflets, and connectors (15) attaching the conduit (2) to the support (10).

Abstract: A safety warning system for detecting glucose in an arterial monitoring or flush system is disclosed. An example of the system comprises a receptacle configured to receive fluid from a line for connecting to a patient, and an indicator arranged to contact the fluid and configured to provide an indication of whether the fluid comprises glucose. The receptacle comprises a gas release path to enable the fluid to displace gas to contact the indicator.

Abstract: Provided is a sensing system for wireless and passive monitoring of strain during a manufacturing process that depends on force to apply the energy into the manufacturing process, the sensing system comprising: at least one surface acoustic wave (SAW) sensor for detecting strain, the at least one SAW sensor being positioned in a force path located on or in the structure of one or more objects under test; and at least one transceiving antenna arrangement being connectable to the at least one SAW sensor, wherein the at least one SAW sensor and the at least one transceiving antenna arrangement are arranged to receive energy from an interrogation signal and output a strain response signal detected by the at least one SAW sensor in response to the interrogation signal.

Abstract: A liquid cooled thermal heat sink is provided. A plurality of jet orifices provide an exit for pressurised liquid to exit a plenum chamber and impinge on a thermal surface whereby they effect a cooling of the thermal surface, the heated liquid being transferred through an exit channel to dissipate heat away from the thermal surface.

Abstract: The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: wherein Q is selected from O, S and Se; J is S or Se; W1 and W2, when present, are independently selected from N and C; R1 and R2 are independently selected from the group consisting of hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, cycloalkenyl, amino, amido, alkylthio, acyl, arylalkyl and acylamido, all of which may be optionally substituted; and wherein at least one of W1 and W2 is present and is a nitrogen atom and when R1 or R2 are cyclic then the respective W1 or W2 may form part of the ring structure. The present invention also relates to pharmaceutical compositions including such compounds, to methods of treatment using such compounds, in particular in relation to NLRP3 inflammasome mediated disorders, and to associated diagnostic uses.

Abstract: The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

Abstract: A method for measuring an electron signal or an electron induced signal may be provided. The method may include providing a threshold number of events or a threshold event rate for a pixel on a detector. The method may include collecting from the detector the threshold number of events or determining that the threshold event rate is achieved, wherein a signal at the detector is an electron signal or an electron induced signal from a sample. The method may include modulating an intensity of an electron source directed to the sample in response.

Abstract: The present invention relates to compounds of formula (I): wherein Q is O or S; R1 is a cyclic group substituted with at least one group X, wherein R1 may optionally be further substituted; X is any group comprising a carbonyl group; and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the dual action of NLRP3 inhibition and the stimulation of insulin secretion.

Abstract: The invention provides a customizable seating support for a seat base that is particularly useful for supporting a physically disabled person in a chair, such as a wheelchair. The seating support includes a posterior portion and a pair of thigh supports that are connected to the posterior portion, via a multi-directional connection, so that the position of at least one thigh support is independently adjustable to tilt upwardly or downwardly or to pivot outwardly relative to the posterior portion to an abducted position. In some embodiments, at least one of the thigh supports may be configured to pivot inwardly relative to the posterior portion to an adducted position.

Abstract: The present invention relates to a method and system energy aware scheduling for sensors (Internet of Things (IoT)). More specifically, the method and system relates to energy scheduling of battery powered sensors or sensors powered using energy harvesters such that accurate and up to date information may be received from said sensors and at the same time minimizing the power utilized by said battery powered or energy harvester powered sensors.

Abstract: A catheter-based ultrasound imaging system configured to provide a full circumferential 360-degree view around an intra-vascular/intra-cardiac imaging-catheter-head by generating a three-dimensional view of the tissue surrounding the imaging-head over time. The ultrasound imaging system can also provide tissue-state mapping capability. The evaluation of the vasculature and tissue characteristics include path and depth of lesions during cardiac-interventions such as ablation. The ultrasound imaging system comprises a catheter with a static or rotating sensor array tip supporting continuous circumferential rotation around its axis, connected to an ultrasound module and respective processing machinery allowing ultrafast imaging and a rotary motor that translates radial movements around a longitudinal catheter axis through a rotary torque transmitting part to rotate the sensor array-tip.

Abstract: A disposable x-ray side marker (100) comprises a non-metallic material (108) having a sufficiently high linear attenuation coefficient to be radiographically visible. The material (108) may be mouldable, and may be or comprise gypsum. The material (108) may have an average atomic number greater than or equal to 11, and may have a linear attenuation coefficient greater than that of mammalian soft tissue.

Abstract: A method and system for generating voltage and/or current oscillations in a single magnetic layer is provided. The method comprises applying a direct voltage/current to the layer in a longitudinal direction; and developing a longitudinal voltage between a pair of longitudinal voltage leads and/or a transverse voltage between a pair of transverse voltage leads. The magnetic layer comprises a ferrimagnetic or antiferrimagnetic material having a first and second magnetic sub-lattice, wherein the first sub-lattice is a dominant sub-lattice such that the charge carriers at the Fermi energy originate predominantly from the dominant sub-lattice and the charge carriers at the Fermi energy are spin polarised. In some embodiments, the dominant current carrying sub-lattice may lack inversion symmetry.