Patents Assigned to Ellem Industria Farmaceutica S.p.A.
  • Patent number: 5079231
    Abstract: The peptides of formula IA--x--Lys--y--B Iin which:A is H, a tripeptide of formula Arg-Ala-Arg or an hexapeptide of formula Glu-Lys-Arg-Arg-Ala-Arg x and y, different one from the other, are an arginine (Arg) or a glutamic acid (Glu) residue;B is OH or a tripeptide Arg-Ala-Arg with the proviso that when A is hydrogen and x is ARg, B is different from OH comprising the steps of:a) binding the Boc-protected carboxyterminal aminoacid to a suitable resin;b) reacting the other Boc-protected aminoacids with the resin-bound carboxyterminal aminoacid in the desired sequence;c) removing the protecting groups and releasing the so obtained peptides from the resin,have valuable pharmacological properties as immunostimulating agents.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: January 7, 1992
    Assignee: Ellem Industria Farmaceutica S.p.A.
    Inventors: Brunetto Brunetti, Marco Prada
  • Patent number: 4929601
    Abstract: The present invention is referred to tripeptides having the following general formula:X-Gly-Ywhere X=L-Arg or D-Arg and Y=L-Asp or D-Asp.These tripeptides, endowed with both immunostimulant and antimetastatic properties, are active not only after parenteral administration, but also after oral treatment.The invention is also related to the procedure for the preparation of said compounds.
    Type: Grant
    Filed: August 2, 1988
    Date of Patent: May 29, 1990
    Assignee: Ellem Industria Farmaceutica, S.p.A.
    Inventors: Brunetto Brunetti, Marco Prada
  • Patent number: 4874844
    Abstract: The tripeptide Arg-Lys-Glu, synthetized by conventional solution methods, and its salts display immunostimulating activity both on maturation of immature T cells and on T cell function.
    Type: Grant
    Filed: April 6, 1987
    Date of Patent: October 17, 1989
    Assignee: Ellem Industria Farmaceutica S.p.A.
    Inventors: Brunetto Brunetti, Marco Prada
  • Patent number: 4737502
    Abstract: Compounds of general formula (I) ##STR1## wherein: m is zero or 1;n is zero, 1, 2, 3 or 4;A is a 3,7-dimethylxanthine-1-yl or 1,3-dimethylxanthine-7-yl residue;show marked anti-platelet activity.
    Type: Grant
    Filed: March 7, 1986
    Date of Patent: April 12, 1988
    Assignee: Ellem Industria Farmaceutica S.p.A.
    Inventor: Rosario Busacca