Abstract: The present invention relates to prodrugs of vascular disrupting agents comprising a vascular disrupting agent (VDA) associated with a MMP proteolytic cleavage site and to the use of such prodrugs in the targeted treatment of cancer.
Type:
Grant
Filed:
March 1, 2018
Date of Patent:
February 9, 2021
Assignee:
ELLIPSES PHARMA LIMITED
Inventors:
Robert Falconer, Jason Gill, Jennifer Xavier, Paul Loadman, Michael Bibby, Laurence Patterson
Abstract: The present invention relates to compounds, and pharmaceutically acceptable salts thereof, comprising a vascular disrupting agent (VDA) associated and a MMP proteolytic cleavage site. The compounds are useful in the treatment of cancer.
Type:
Grant
Filed:
March 16, 2018
Date of Patent:
February 11, 2020
Assignee:
ELLIPSES PHARMA LIMITED
Inventors:
Jason Gill, Paul Loadman, Rob Falconer, Laurence Patterson, Jennifer Xavier, Michael Bibby