Patents Assigned to Eloxx Pharmaceuticals Ltd.
  • Aminoglycoside derivatives and uses thereof in treating genetic disorders
    Patent number: 11786539
    Abstract: Novel pseudo-trisaccharide aminoglycosides, represented by Formula I, as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: October 17, 2023
    Assignee: ELOXX PHARMACEUTICALS LTD.
    Inventor: Timor Baasov
  • Aminoglycoside derivatives and uses thereof in treating genetic disorders
    Patent number: 11613551
    Abstract: Novel aminoglycosides, represented by Formulae Ia and Ib, as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: March 28, 2023
    Assignee: ELOXX PHARMACEUTICALS LTD.
    Inventors: Timor Baasov, Shmuel Tuvia
  • Aminoglycoside derivatives and uses thereof in treating genetic disorders
    Patent number: 11306115
    Abstract: Novel pseudo-disaccharide and pseudo-trisaccharide aminoglycosides, represented by Formulae I or Ia, as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: April 19, 2022
    Assignee: ELOXX PHARMACEUTICALS LTD.
    Inventor: Timor Baasov
  • Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof
    Patent number: 11136345
    Abstract: Synthetic pathways for preparing pseudo-trisaccharide aminoglycoside compounds represented by Formula I or Ia as defined in the specification and donor and acceptor compounds useful for preparing such compounds are provided. A process of stereoselectively preparing compounds represented by Formula III as defined in the specification, while avoiding chromatographic separation of stereoisomers are also provided. Compounds prepared by the described processes and uses thereof are also provided.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: October 5, 2021
    Assignee: ELOXX PHARMACEUTICALS LTD.
    Inventors: Michael Mizhiritskii, Mani Bushan Kotala, Ravinder Palidi
  • Aminoglycoside derivatives and uses thereof in treating genetic disorders
    Patent number: 10899785
    Abstract: Novel aminoglycosides, represented by Formulae Ia and Ib, as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: January 26, 2021
    Assignee: ELOXX PHARMACEUTICALS LTD.
    Inventors: Timor Baasov, Shmuel Tuvia
  • Aminoglycoside derivatives and uses thereof in treating genetic disorders
    Patent number: 10786520
    Abstract: Novel pseudo-trisaccharide aminoglycosides, represented by Formula I, as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: September 29, 2020
    Assignee: ELOXX PHARMACEUTICALS LTD.
    Inventor: Timor Baasov
  • Use of aminoglycoside analogs in the treatment of Rett syndrome
    Patent number: 10576095
    Abstract: Compounds, methods and uses of pseudo-trisaccharide aminoglycosides represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification, in the treatment of Rett syndrome are disclosed.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: March 3, 2020
    Assignee: ELOXX PHARMACEUTICALS LTD.
    Inventors: Timor Baasov, Shmuel Tuvia, Dori Pelled
  • USE OF AMINOGLYCOSIDE ANALOGS IN THE TREATMENT OF RETT SYNDROME
    Publication number: 20190183915
    Abstract: Compounds, methods and uses of pseudo-trisaccharide aminoglycosides represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification, in the treatment of Rett syndrome are disclosed.
    Type: Application
    Filed: January 28, 2019
    Publication date: June 20, 2019
    Applicant: Eloxx Pharmaceuticals Ltd.
    Inventors: Timor BAASOV, Shmuel Tuvia, Dori Pelled
  • AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS
    Publication number: 20190016746
    Abstract: Novel aminoglycosides, represented by Formulae I, Ia, III and IIIa, as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
    Type: Application
    Filed: September 2, 2016
    Publication date: January 17, 2019
    Applicant: Eloxx Pharmaceuticals Ltd.
    Inventors: Timor BAASOV, Shmuel TUVIA