Abstract: The present disclosure relates to IL2 muteins (or “IL2 mutants”), an isolated polynucleotide encoding the IL2 mutein, an isolated vector containing the polynucleotide, a host cell containing the isolated polynucleotide or the isolated vector which encoding the IL2 mutein, a fusion protein containing the IL2 mutein, a pharmaceutical composition containing the IL2 mutein/muteins, and uses of such molecules in IL2 immunotherapy.
Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that binds to LILRB2 (Leukocyte Immunoglobulin Like Receptor B2), the anti-LILRB2 antibody or antigen-binding fragment thereof could block the signaling pathway and upregulates the immune response to a LILRB2-related disease, disorder, or condition.