Abstract: Saturated aliphatic straight chain dicarboxylic acids having a total number of carbon atoms which are divisible by four, are selectively toxic to certain tumor cells while non-toxic to normal cells of the same origin. Octacosanedioic acid is particularly preferred as it is a component of normal blood serum. Compositions containing these compounds may be used in the treatment of certain malignancies.
Type:
Grant
Filed:
March 1, 1984
Date of Patent:
January 23, 1990
Assignees:
David Rubin, Ely J. Rubin, Adolf W. Schwimmer, Irwin S. Schwartz, Century Laboratories, Inc.
Abstract: Mandelonitrile-.beta.-D-glucuronic acid can be produced by tritylating mandelonitrile-.beta.-D-glucoside, acetylating the obtained product, and then simultaneously detritylating and oxidizing in order to obtain mandelonitrile-.beta.-D-triacetyl glucuronic acid. This compound may then be deacetylated to obtain mandelonitrile-.beta.-D-glucuronic acid or the salt thereof.
Type:
Grant
Filed:
November 10, 1981
Date of Patent:
December 25, 1984
Assignees:
Ely J. Rubin, David Rubin, Century Science Corp.